White Sox vs Guardians Prediction 9/13/2025 Today’s MLB Picks

In this article we will formulate a White Sox vs Guardians prediction for this MLB game on Saturday, September 13th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 57-91 this year after they lost game one by a score of 4-0 on Friday night. Chicago went down in the fourth inning and never got their offense going in the shutout loss. The White Sox recorded two hits in the game and they were led by Meidroth and Robertson, who both had one hit in the loss. Chicago started Perez, who allowed four hits and three earned runs over 6.2 innings for the loss, while Wilson allowed one earned run in relief. 

Prior to this series, the White Sox won two out of three against the Rays and two out of three against the Tigers. Chicago has won three of their last five games and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.22 ERA with a 1.36 WHIP and a .247 opponent batting average, while the offense has scored 597 runs with a .235 batting average and a .304 on base percentage this season. Lenyn Sosa has led Chicago with 20 home runs and 67 RBIs, while Andrew Benintendi has added 19 home runs and 60 RBIs this year. The projected starting pitcher for Chicago is Davis Martin, who is 6-9 with a 4.03 ERA and a 1.28 WHIP over 127.1 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 76-71 this year after they won game one by a score of 4-0 last night. Cleveland scored once in the fourth, fifth, seventh, and eighth to secure the shutout victory. The Guardians recorded six hits and they committed one error in the game, while they were led by Hedges, Jones, Fry, and Martinez, who all had one RBI in the win. Cleveland started Bibee, who allowed two hits and zero earned runs over 9.0 innings for the complete game shutout. 

Prior to this series, the Guardians won three out of four against the Royals and three out of four against the Rays. Cleveland has won seven of their last eight games and they are second in the AL Central standings. The Cleveland pitching staff has a 3.83 ERA with a 1.29 WHIP and a .243 opponent batting average, while the offense has scored 574 runs with a .225 batting average and a .296 on base percentage this season. Jose Ramirez has led Cleveland with 28 home runs and 77 RBIs, while Kyle Manzardo has added 26 home runs and 67 RBIs this year. The projected starting pitcher for Cleveland is Parker Messick, who is 2-0 with a 1.93 ERA and a 1.33 WHIP over 23.1 innings pitched this season. 

Why the Guardians will beat the White Sox 

The White Sox have lost each of their last 11 Saturday night games against teams that held a winning record.
The Guardians have won seven of their last eight games.
The White Sox have failed to cover the run line each of their last eight Saturday night games against American League opponents that held a winning record.
The Guardians have covered the run line in seven of their last eight games against American League opponents.
The White Sox have trailed after 5 innings in five of their last six games as road underdogs.

Total Runs Facts
Each of the Guardians’ last four home games have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Guardians’ last nine games against AL Central opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the White Sox’s last seven games as underdogs.

Cleveland Guardians Player Prop Facts

Jose Ramirez has hit a home run in two of the Guardians’ last three games at Progressive Field against AL Central opponents that held a losing record.
Steven Kwan has recorded at least one hit in each of his eight previous Saturday night appearances against AL Central teams that held a losing record.

Chicago White Sox Player Prop Facts

Andrew Benintendi has hit at least one home run in three of his last five appearances after playing the previous day.
Luis Robert has recorded at least one hit in each of his last seven appearances at Progressive Field against opponents that held a winning record.

White Sox vs Guardians Prediction 

Cleveland is heating up once again and they are starting to make a push in the AL wild card race. The Guardians are 39-34 at home this year, while the White Sox are 25-48 on the road. Chicago has played much better over the last few weeks and they are starting Martin, who has allowed two earned runs or fewer in three of his last five starts. Cleveland is going with Messick, who has allowed one earned run or fewer in three of his last four outings. I really like how Messick has pitched in limited action this year and he should have another good outing here. Take Cleveland by at least two runs.