Jun 23, 2025; San Diego, California, USA; Washington Nationals left fielder James Wood (29) and CJ Abrams (5) celebrate after the Nationals beat the San Diego Padres 10-6 at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

Washington Nationals vs San Diego Padres Prediction 06/25/2025 Picks

Pick details

Washington (33-47) vs San Diego (43-36)

June 25, 2025 at 04:10 PM EDT

The Line: Betting Odds: San Diego -1.5 — Over/Under: +8

(Get latest betting odds)

In this article, we will formulate a Nationals vs Padres prediction for this MLB game on Wednesday, June 25, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

Washington Nationals Betting Preview

The Washington Nationals (33-47, 17-23 Away) were on an 11-game losing skid but improved a bit since and now are in a hot-and-cold form after winning three of the last six games. After losing six straight series, including defeats to the Rockies and Dodgers, the Nationals have a chance to win one in a rubber match against the Padres. They won Game 1, but fell short 4-3 on Tuesday. James Wood led the offense with two RBI, while Trevor Williams took the loss after allowing four runs on seven hits with three strikeouts and two walks in 5.0 innings.

This year, the Nationals average 4.29 runs per game (15th in the MLB) on a .243/.309/.394 triple-slash. When it comes to pitching, the Nationals’ staff has a 5.00 ERA (28th) and 1.38 WHIP (24th). James Wood leads the Nationals with a .281 batting average, 22 home runs, and 63 RBI this season.

The projected starting pitcher for the Nationals is MacKenzie Gore, who is 3-7 in 16 starts this season, with a 3.19 ERA and 1.19 WHIP in 93.0 innings.

San Diego Padres Betting Preview

The San Diego Padres (43-36, 24-14 Home) lost three straight series to the Dodgers, Diamondbacks, and Dodgers again, but bounced back with a win against the Kansas City Royals. The Padres lost the opening game of the series against the Washington Nationals, but answered with a 4-3 victory last night. Ryan Bergert pitched for 3.0 innings in a no-decision, allowing three runs on five hits with four strikeouts and three walks. Jason Adam was credited with the win.

This season, the Padres average 4.24 runs per game (18th in the MLB) on a .249/.316/.381 triple-slash. When it comes to pitching, the Padres’ staff has a 3.65 ERA (9th) and 1.23 WHIP (11th). Manny Machado leads the Padres with a .302 batting average, 13 home runs, and 47 RBI this season.

Nick Pivetta will take the mound for the Padres on Wednesday. The 32-year-old right-hander has a 7-2 record in 15 starts this year with a 3.64 ERA and 1.08 WHIP in 84.0 innings.

Total Runs Facts

Nine of the Nationals’ last 10 day games after playing the previous day have gone UNDER the total runs line.
Three of the Padres’ last four games against NL East opponents have gone OVER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Padres’ last nine day games.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Nationals’ last four games as road underdogs against NL West opponents.

Matchup/League Facts

The Padres rank 26th in the league for home runs this season (69).
The Padres rank 5th in the league for hits allowed this season (597).
The Nationals rank 4th in the league for strikeouts against this season (600).
The Nationals rank 27th in the league for hits allowed this season (709).

Nationals vs Padres Prediction

The Padres won seven of the previous ten H2H encounters, while six of the last ten went Over. I am going with another Over, even though the teams are starting MacKenzie Gore and Nick Pivetta, so of their best starters. Pivetta is not playing well in June, registering a 6.23 ERA and allowing multiple runs in each of his previous five starts. Gore, on the other hand, is in a better form, but he surrendered multiple runs in his last three starts. I am backing both offenses to score 2+ runs early on. The total is not high, so go with Over.

Oliver Zivic's Pick: Over 7.5

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