Jun 27, 2025; Baltimore, Maryland, USA; Tampa Bay Rays first baseman Jonathan Aranda (62) hits a single during the seventh inning against the Baltimore Orioles at Oriole Park at Camden Yards. Mandatory Credit: Daniel Kucin Jr.-Imagn Images

Tampa Bay Rays vs Baltimore Orioles Prediction 06/28/2025 Picks

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Tampa Bay (46-36) vs Baltimore (35-46)

June 28, 2025 at 04:05 PM EDT

The Line: Betting Odds: Baltimore +1.5 — Over/Under: +10

(Get latest betting odds)


The Tampa Bay Rays and Baltimore Orioles meet Saturday in MLB action at Oriole Park at Camden Yards. Here’s a Tampa Bay Rays vs Baltimore Orioles Prediction. This article will include a Tampa Bay Rays vs Baltimore Orioles Pick.

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 46-36 on the year and play the Athletics, Twins, and Tigers next. The Tampa Bay Rays are batting .258 on the season, have a .323 OBP, and a .408 slugging percentage. The Tampa Bay Rays pitching staff has a 3.70 ERA and a 1.19 WHIP. Yandy Diaz leads the Tampa Bay Rays with 89 hits and 44 RBI, while Jonathan Aranda and Brandon Lowe have combined for 166 hits and 89 RBI. 

Zack Littell gets the ball for the Tampa Bay Rays, and he is 6-7 with a 3.78 ERA and 66 strikeouts this season. Littell is 1-3 with a 3.03 ERA and 25 strikeouts in his career against the Baltimore Orioles.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 35-46 on the year and play the Rangers, Braves, and Mets next. The Baltimore Orioles are batting .240 on the season, have a .307 OBP, and a .399 slugging percentage. The Baltimore Orioles pitching staff has a 4.92 ERA and a 1.42 WHIP. Gunnar Henderson leads the Baltimore Orioles with 79 hits and 25 RBI while Jackson Holliday and Ryan O’Hearn have combined for 143 hits and 63 RBI.

Zach Eflin gets the ball for the Baltimore Orioles, and he is 6-4 with a 5.46 ERA and 42 strikeouts this season. Eflin is 1-3 with a 5.04 ERA and 18 strikeouts in his career against the Tampa Bay Rays.

Why the Baltimore Orioles will win

The Orioles have won each of their last four day games following a home win.
The Rays have lost five of their last six road games against AL East opponents that held a losing record.
The Rays have failed to cover the run line each of their last six games at Oriole Park at Camden Yards against American League opponents that held a losing record.
The Orioles have covered the run line in seven of their last nine games as favorites against the Rays.
The Orioles have led after 3 innings in three of their last four games as favorites against AL East opponents.
The Rays have trailed after 5 innings in each of their last three games at Oriole Park at Camden Yards against American League opponents that held a losing record.

Why the Tampa Bay Rays will win

The Rays have won eight of their last nine games as road underdogs against AL East opponents following a road loss.
The Orioles have lost each of their last three games as favorites against AL East opponents following a home win.
The Rays have covered the run line in each of their last 11 games as underdogs against AL East opponents following a road loss.
The Orioles have failed to cover the run line in seven of their last eight day games against American League opponents that held a winning record.
The Rays have led after 5 innings in eight of their last 10 day games against American League opponents.
The Rays have led after 3 innings in four of their last five games against opponents that held a losing record.

Baltimore Orioles Player Prop Facts

Colton Cowser has hit a home run in three of the Orioles’ last four games against the Rays.
Zach Eflin has recorded four or more strikeouts in each of his last eight appearances with his team as a home favorite against AL East opponents.
Gary Sanchez has recorded at least one hit in each of his last eight appearances with his team as a home favorite.
Zach Eflin has recorded a win in three of his last four appearances at Oriole Park at Camden Yards against opponents that held a winning record.
Ryan Mountcastle has recorded at least one Double in three of his last four home appearances against opponents that held a winning record.

Tampa Bay Rays Player Prop Facts

Brandon Lowe has hit a home run in three of his last four appearances in day games against AL East teams that held a losing record.
Ha-Seong Kim has recorded at least one hit in each of his last seven appearances against AL East opponents.
Jonathan Aranda ranks 3rd amongst qualified players for On Base Percentage (.411) this season.

Tampa Bay Rays vs Baltimore Orioles Prediction

As I’ve said a lot this season, the Rays are a good team to back because they win, and they don’t have inflated lines most of the time. That’s a good spot here as well with Littell on the mound, a guy who has a 3.78 ERA and 1.10 WHIP, and he’s allowed just nine runs in his last 23 innings. Eflin has allowed 22 hits and 13 runs in his last eight innings. In 66 at bats against current Rays, Eflin has a .364 allowed batting average and .400 on base percentage. The Rays should be excited about this matchup given Eflin’s form and the history against him. Give me the Rays with solid confidence.

Randy Chambers's Pick: Tampa Bay Rays

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