St. Louis Cardinals vs Milwaukee Brewers Prediction 6/15/25 MLB Picks

The Saint Louis Cardinals are visiting the Milwaukee Brewers on Sunday, June 15th at the American Family Field in the fourth game of this series, with the Brewers having a 2-1 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Saint Louis Cardinals vs Milwaukee Brewers Prediction. We will examine:

The Milwaukee Brewers’ recent form and player performance

The Saint Louis Cardinals’ recent form and player performance

Recent betting trends and streaks involving the Milwaukee Brewers

Recent betting trends and streaks involving the Saint Louis Cardinals

Recent betting trends in games played between the Saint Louis Cardinals vs Milwaukee Brewers

A summary that ties it all together and produces a favorable betting outcome for the Saint Louis Cardinals vs Milwaukee Brewers game

Milwaukee Brewers Preview

The Milwaukee Brewers have a 38-34 record this season and are sitting in second place in the NL Central. They have a 22-15 home record and are 27-42 in over/under. They are coming off a 5-8 home defeat by the Cardinals, which ended their previous two-game winning streak. Under is 6-3 in their last 9 games, and are playing the Cubs and the Twins next.

The Brewers have a .236 batting average this season, a .313 OBP, and a .363 Slugging percentage. Milwaukee’s pitching staff has a 3.81 ERA and 1.30 WHIP.  Jackson Churio leads the Brewers with 79 hits, while Christian Yelich leads the team in RBI, with 42, adding a team-high 13 home runs. Sal Frelick is the team’s best hitter with a .299 batting average.

Quinn Priester (R) is the projected starting pitcher for the Brewers, and he has a 4-2 record, 3.65 ERA, and 1.30 WHIP. He has been weaker at home, with a 4.21 ERA across five home games, but he has been in great form lately, having just one earned run in five of his last seven starts. In his previous start against the Cardinals this season, he got torched for 5 earned runs in 5 innings pitched.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 37-34 record this season and are sitting in third place in the NL Central. The Cardinals have a 15-20 road record and are 38-31 in over/under. They are coming off an 8-5 road victory over the Brewers, which snapped their previous six-game losing streak. Under is 3-1 in their last 4 games, and they are playing the White Sox and the Reds next.

The Cardinals have a .255 batting average this season, a .326 OBP, and a .391 Slugging percentage. Saint Louis’ pitching staff has a 4.00 ERA and 1.28 WHIP. Brendan Donovan leads the Cardinals with 77 hits and a team-high .310 batting average, while Wilson Contreras leads the team in RBI, with 44, adding a team-high 9 home runs.

Miles Mikolas (R) is the projected starting pitcher for the Cardinals, and he has a 4-3 record, 4.48 ERA, and 1.31 WHIP. He has been better on the road, with a 3.97 ERA across seven road starts, but he has been terrible in his last three starts, having given up 13 runs across 15 innings pitched. Miles Mikolas is 10-6 with an ERA of 3.87 and 97 strikeouts in 19 appearances versus the Brewers in his career.

Why the Milwaukee Brewers will win

• The Brewers have won each of their last nine day games against NL Central opponents following a home loss.
• The Cardinals have lost nine of their last 10 day games against NL Central opponents following a road win.
• The Brewers have covered the run line in each of their last six day games against NL Central opponents following a home loss.
• The Cardinals have failed to cover the run line in each of their last five day games against NL Central opponents following a road win.
• The Cardinals have lost the first inning in three of their last four day games at American Family Field.
• The Brewers have led after 5 innings in eight of their last nine day games against the Cardinals at American Family Field.
• The Brewers have led after 3 innings in four of their last five day games against the Cardinals at American Family Field.

Why the St. Louis Cardinals will win

• The underdogs have won five of the Cardinals’ last six games.
• The Brewers have lost each of their last three day games against National League opponents.
• The Cardinals have covered the run line in each of their last eight games as road underdogs against National League opponents.
• The Brewers have failed to cover the run line in each of their last seven games as favorites against National League opponents.
• The Cardinals have won the first inning in four of their last five games as road underdogs against NL Central opponents.
• The Brewers have trailed after 5 innings in three of their last four home day games.
• The Cardinals have led after 3 innings in three of their last four day games against NL Central opponents.

Total Runs Facts

• Four of the Cardinals’ last five games against NL Central opponents have gone UNDER the total runs line.
• Four of the Brewers’ last five home games against NL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the Brewers’ last 11 home games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Cardinals’ last nine day games at American Family Field.

Matchup/League Facts

• The Brewers rank 2nd in the league for steals this season (88).
• The Brewers rank 28th in the league for slugging percentage this season (.363).
• The Cardinals rank 29th in the league for strikeouts this season (506).
• The Cardinals rank 3rd in the league for walks allowed this season (193).

Saint Louis Cardinals vs Milwaukee Brewers Prediction

The Brewers are 3-1 in their last 4 meetings against the Cardinals, but the Cardinals are 3-2 in their last 5 visits to Milwaukee. Under is 5-2 in their last 7 meetings.

In this Saint Louis Cardinals vs Milwaukee Brewers Prediction, the Brewers are coming as -130 home favorites. Both teams have almost identical overall records, but the Brewers have been good at home, while the Cardinals are below average on the road. I don’t trust either pitcher in this matchup, as they have a combined 8.69 ERA, and Mikolas has been in terrible form lately. Both teams are better against righties, averaging 9.5 runs combined against right-handed pitching, and yesterday’s game had 13 total runs. I expect another high-scoring affair, so take the over 8.5 runs in this one.

Nikos Lagouretos's Pick: Over 8.5