St. Louis Cardinals vs Detroit Tigers Prediction 4/4/2026 Today’s MLB Picks

In this article, we will formulate a Cardinals vs Tigers Prediction for this MLB matchup on Saturday, April 4th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Detroit Tigers Preview

The Detroit Tigers have a 3-4 record this season and are sitting in the fourth place of the AL Central. They have a 1-0 home record and are coming off a 4-0 home win over the Cardinals. Their previous three games were a 0-1, 5-7 and a 6-9 road loss to the Diamondbacks.

The Tigers have a .228 batting average this season, .306 OBP and .323 Slugging percentage. Detroit’s pitching staff has a 3.20 ERA and 1.25 WHIP. Colt Keith is the team’s best hitter with a .364 batting average. Dillon Dingler leads the team in RBI with 7, also adding a team-high two home runs.

Jack Flaherty (R) is the projected starting pitcher for the Tigers, and he has a 0-1 record, 4.15 ERA and 1.85 WHIP.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 4-3 record this season and are sitting in the second place of the NL Central. They have a 0-1 road record and are coming off a 0-4 road loss to the Tigers. Their previous three games were a 2-1 home win, a 3-0 home win and a 2-4 home loss to the Mets.

The Cardinals have a .220 batting average this season, .278 OBP and .347 Slugging percentage. St. Louis’ pitching staff has a 4.29 ERA and 1.49 WHIP. Victor Scott II is the team’s best hitter with a .333 batting average. Nolan Gorman leads the team in RBI with 6, also adding a team-high two home runs.

Dustin May (R) is the projected starting pitcher for the Cardinals, and he has a 0-1 record, 13.50 ERA and 2.75 WHIP.

St. Louis Cardinals @ Detroit Tigers Betting Trends: April 4, 2026

• Probable Starting Pitcher: Jack Flaherty      Record this season: 0-1      ERA: 4.15
• Home Record: 0-0
• Last 5 against Cardinals: 0-0

Why the Detroit Tigers will win

• The Cardinals have lost each of their last six road games against American League opponents.
• The home team has won each of the Tigers’ last five games.
• The Cardinals have failed to cover the run line in each of their last six road games against American League opponents.
• The home team has covered the run line in each of the Tigers’ last five games.
• The Tigers have led after 3 innings in three of their last four games against NL Central opponents that held a winning record.
• The Cardinals have trailed after 5 innings in each of their last six road games.

• Probable Starting Pitcher: Dustin May      Record this season: 0-1      ERA: 13.50
• Road Record: 0-0
• Last 5 against Tigers: –

Why the St. Louis Cardinals will win

• The Tigers have lost each of their last eight games as favorites after playing the previous day.
• The Cardinals have won each of their last five games as underdogs against AL Central opponents following a loss.
• The Tigers have failed to cover the run line in each of their last eight games as favorites after playing the previous day.
• The Cardinals have covered the run line in each of their last five games as underdogs against AL Central opponents following a loss.
• The Cardinals have led after 3 innings in six of their last seven games against AL Central opponents.
• The Tigers have trailed after 5 innings in four of their last five games against NL Central opponents.

Total Runs Facts

• Each of the Cardinals’ last four games have gone UNDER the total runs line.
• Six of the Tigers’ last seven home games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last eight Saturday day games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last four home games.

Detroit Tigers Player Prop Facts

• Riley Greene has hit a home run in three of the Tigers’ last four games as favorites against the Cardinals.
• Jack Flaherty has recorded six or more strikeouts in eight of his last nine home appearances against NL Central opponents that held a winning record.
• Jake Rogers has recorded at least one hit in each of his last 10 home appearances against NL Central opponents.
• Jack Flaherty has recorded a win in three of his last four home appearances against NL opponents that held a winning record.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in four of his last seven road appearances against AL Central opponents.
• Dustin May has recorded five or more strikeouts in each of his last five Saturday appearances.
• Alec Burleson has recorded at least one hit in each of his last eight road appearances against AL Central opponents.

Matchup/League Facts

• The Tigers rank 30th in the league for home runs this season (2).
• The Tigers rank 28th in the league for slugging percentage this season (.323).
• The Cardinals rank 30th in the league for strikeouts this season (39).
• The Cardinals rank 29th in the league for hits allowed this season (69).

Cardinals vs Tigers Prediction

The Tigers are 5-1 in their last 6 meetings against the Cardinals, having won their last three meetings in Detroit.  

In this Cardinals vs Tigers Prediction, the Tigers are coming as -160 home favorites. The Tigers shut out the Cardinals yesterday with a 4-0 score and are putting Flaherty on the mound today who has been historically better at home. On the flip side, Dustin May takes the mound for the Cardinals and he was torched in his first start of the season by the Rays with 6 earned runs and has been playing historically worse on the road. On top of that, the Cardinals have been weaker against right-handed pitching this season, so give me the Tigers on the moneyline in this one.

Nikos Lagouretos's Pick: Detroit Tigers ML