Cincinnati Reds shortstop Elly De La Cruz (44) backhands a sharply hit ground ball off the bat of Harrison Bader in the ninth inning of the MLB interleague game between the Cincinnati Reds and the Minnesota Twins at Great American Ball Park in downtown Cincinnati on Thursday, June 19, 2025. The Twins won, 12-5.

St. Louis Cardinals vs Cincinnati Reds Prediction 06/20/2025 Picks

Pick details

Cincinnati (39-36) vs St. Louis (40-35)

June 20, 2025 at 07:15 PM EDT

The Line: Betting Odds: St. Louis -135 — Over/Under: +9

(Get latest betting odds)

The Cincinnati Reds and the St. Louis Cardinals meet Friday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cincinnati Reds vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Cincinnati Reds will send out Brady Singer for the start here and Singer is 7-4 with a 4.34 ERA and 60 strikeouts this season. In his career, Singer is 0-2 with a 4.00 ERA and 8 strikeouts against the Cardinals. Andre Pallante will start this one for St. Louis and is 4-3 with a 4.83 ERA and 54 strikeouts this season. In his last five starts against the Reds, Pallante is 3-2 with a 2.96 ERA and 24 strikeouts.

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to rebound from their 12-5 loss at the hands of the Minnesota Twins last time out to sit at 39-36 on the year. After this series, the Reds will head home for a series against the New York Yankees.

Reds Have Four-Game Win Streak Snapped

Elly De La Cruz has 75 hits with 16 home runs, 50 RBIs, 14 doubles and 21 stolen bases while TJ Friedl has 80 hits with 13 doubles, 8 home runs and 29 RBIs with 9 stolen bases. Gavin Lux has added 60 hits with 14 doubles and 31 RBIs while Spencer Steer has 6 home runs and 25 RBIs and Matt McLain has added 8 homers, 26 RBIs and 11 stolen bases as well on the year. Jose Trevino’s also chipped in 15 doubles as well this season.

Why the Cincinnati Reds will win

The Cardinals have lost each of their last four games as favorites after playing the previous day.
The Reds have won each of their last four games as underdogs after playing the previous day.
The Reds have covered the run line in each of their last 11 games as underdogs against NL Central opponents following a home loss.
The Cardinals have failed to cover the run line in 11 of their last 12 games as favorites against the Reds following a road win.

Cincinnati Reds Player Prop Facts

Elly De La Cruz has hit a home run in each of the Reds’ last four road games against opponents that held a winning record.
Spencer Steer has recorded at least one Double in three of the Reds’ last four night games against NL opponents that held a winning record.
Elly De La Cruz has recorded at least one RBI in each of the Reds’ last four road games against opponents that held a winning record.
Elly De La Cruz has scored at least one run in each of the Reds’ last five games against opponents that held a winning record.
Brady Singer has recorded four or more strikeouts in each of his eight previous appearances in night games against NL teams that held a winning record.
TJ Friedl has recorded at least one hit in each of the Reds’ last 13 night games.
Brady Singer has recorded a win in three of his last four appearances with the Reds as underdogs.
Elly De La Cruz ranks T5th in the league in Steals (21) this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to build on their double-header sweep over the White Sox thanks to a 5-4 win in the first leg and 8-6 win over the White Sox in the second leg to improve to 40-35 on the year. After this series, the Cardinals will welcome the Chicago Cubs to town.

Cardinals Pull Off Confidence Building Sweep

Brendan Donovan has a team-high 83 hits along with 21 doubles, 4 home runs and 27 RBIs while Lars Nootbaar has 62 hits with 9 home runs, 30 RBIs, 12 doubles and 4 stolen bases. Nolan Arenado also has 66 hits with 11 doubles, 9 home runs and 38 RBIs of his own and Victor Scott II has 52 hits with 8 doubles, a triple, 24 RBIs and a team-high 20 stolen bases. Willson Contreras has also chipped in 66 hits with 16 doubles, 10 home runs and 50 RBIs of his own as well this season. Masyn Winn’s added 60 points with 12 doubles, 6 home runs and 23 RBIs and Alec Burleson’s added 66 hits with 10 doubles, 7 home runs and 26 RBIs.

Why the St. Louis Cardinals will win

The Cardinals have won 10 of their last 11 home games against National League opponents.
The Reds have lost four of their last five games against NL Central opponents that held a winning record.
The Cardinals have covered the run line in nine of their last 10 night games against National League opponents.
The Reds have failed to cover the run line in each of their last four road games against National League opponents after playing the previous day.

St. Louis Cardinals Player Prop Facts

Alec Burleson has hit a home run in two of the Cardinals’ last three games as favorites.
Willson Contreras has recorded at least one hit in 17 of his last 18 home appearances against opponents that held a winning record.
Willson Contreras has scored a run in five of the Cardinals’ last six games as home favorites.
Nolan Arenado has recorded a Double in three of his last four appearances in night games against NL Central teams that held a winning record.
Willson Contreras has recorded at least one RBI in each of his last eight appearances with the Cardinals as home favorites.
Victor Scott II ranks T7th in the league in Steals (20) this season.

Total Runs Facts

Each of the Reds’ last five games as road underdogs have gone OVER the total runs line.
Each of the last four games between the Reds and Cardinals at Busch Stadium have gone UNDER the total runs line.

Cincinnati Reds vs. St. Louis Cardinals Prediction

I’m on the Reds here. I get that Andre Pallante has some solid numbers in his career against the Reds, but the Reds, despite Thursday’s loss, have still done a good job hitting against right-handed pitching as of late and I don’t really want to get in front of that right now. It’s going to take more than a sweep over the Chicago White Sox to convince me that the Cardinals are back on track and I think that the value is with Cincinnati here. Give me the Reds in this one.

Chris Ruffolo's Pick: Cincinnati +115

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