St. Louis Cardinals vs Chicago Cubs Prediction 07/04/2025 Picks

The St. Louis Cardinals and Chicago Cubs meet Friday in MLB action at Wrigley Field. Here’s a St. Louis Cardinals vs Chicago Cubs Prediction. This article will include a St. Louis Cardinals vs Chicago Cubs Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 47-41 on the year and play the Nationals and Braves next. The St. Louis Cardinals are batting .253 on the season, have a .323 OBP, and a .393 slugging percentage. The St. Louis Cardinals pitching staff has a 3.94 ERA and a 1.26 WHIP. Brendan Donovan leads the St. Louis Cardinals with 91 hits and 31 RBI, while Willson Contreras and Nolan Arenado have combined for 150 hits and 92 RBI. 

Miles Mikolas gets the ball for the St. Louis Cardinals, and he is 4-5 with a 4.76 ERA and 56 strikeouts this season. Mikolas is 6-6 with a 3.17 ERA and 88 strikeouts in his career against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 52-35 on the year and play the Twins and Yankees next. The Chicago Cubs are batting .255 on the season, have a .326 OBP, and a .442 slugging percentage. The Chicago Cubs pitching staff has a 3.78 ERA and a 1.24 WHIP. Kyle Tucker leads the Chicago Cubs with 93 hits and 52 RBI while Nico Hoerner and Pete Crow-Armstrong have combined for 179 hits and 99 RBI.

Colin Rea gets the ball for the Chicago Cubs, and he is 5-3 with a 4.37 ERA and 56 strikeouts this season. Rea is 1-3 with a 4.37 ERA and 27 strikeouts in his career against the St. Louis Cardinals.

Why the Chicago Cubs will win

The Cubs have won seven of their last eight games at Wrigley Field after going to extra innings.
The Cardinals have lost each of their last five games against National League opponents.
The Cardinals have failed to cover the run line in each of their last four day games against National League opponents.
The Cubs have led after 3 innings in each of their last three games against National League opponents that held a winning record.
The Cardinals have trailed after 5 innings in four of their last five day games against National League opponents.

Why the St. Louis Cardinals will win

The Cubs have lost each of their last five games as home favorites against the Cardinals following a home win.
The Cardinals have won each of their last four games as road underdogs against the Cubs following a loss.
The Cardinals have covered the run line in each of their last seven games as road underdogs following a road loss.
The Cubs have failed to cover the run line in each of their last eight Friday games as home favorites against NL Central opponents.

Chicago Cubs Player Prop Facts

Ian Happ has hit at least one home run in three of the Cubs’ last four games at Wrigley Field against opponents that held a winning record.
Nico Hoerner has recorded at least one hit in each of the Cubs’ last 10 games against NL Central opponents that held a winning record.
Seiya Suzuki ranks T6th in the league in Home Runs (23) this season.

St. Louis Cardinals Player Prop Facts

Miles Mikolas has recorded four or more strikeouts in each of his last five appearances with the Cardinals as underdogs against NL opponents.
Nolan Arenado has recorded at least one hit in each of his 11 previous Friday day appearances with his team as an underdog.
Lars Nootbaar has hit a home run in each of his last two appearances against NL opponents that held a winning record.

St. Louis Cardinals vs Chicago Cubs Prediction

The Cardinals have been shutout in three straight games and five of their last eight games overall. Seeing Mikolas on the mound doesn’t make things any more intriguing when he’s allowed 34 hits and 19 earned runs in his last 26 innings. Rea has had his issues as well especially at home where he has a 4.53 ERA and .287 allowed batting average, but the Cubs are rolling this week and have the offense to make up for a subpar pitching showing. Backing the Cardinals isn’t an option these days with their inability to score. Give me the Cubs.

Randy Chambers's Pick: Chicago Cubs