St. Louis Cardinals vs Chicago Cubs Prediction 06/24/2025 Picks

The Chicago Cubs are visiting the Saint Louis Cardinals on Tuesday, June 24^th at the Busch Stadium in the second game of this series, with the Cardinals having the 1-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs Saint Louis Cardinals Prediction. We will examine:
The Saint Louis Cardinals recent form and player performance
The Chicago Cubs recent form and player performance
Recent betting trends and streaks involving the Saint Louis Cardinals
Recent betting trends and streaks involving the Chicago Cubs
Recent betting trends in games played between the Chicago Cubs vs Saint Louis Cardinals
A summary that ties it all together and produces a favorable betting outcome for the Chicago Cubs vs Saint Louis Cardinals game

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 43-36 record this season and are sitting on the third place of the NL Central. The Cardinals have a 25-15 home record and are 42-34 in over/under They are coming off an 8-2 home victory over the Cubs, and are 6-1 in their last 7 games. They are playing the Guardians and the Pirates next.

The Cardinals have a .255 batting average this season, .327 OBP and .396 Slugging percentage. Saint Louis’ pitching staff has a 3.90 ERA and 1.26 WHIP. Brendan Donovan leads the Cardinals with 85 hits, while Wilson Contreras leads the team in RBI, with 50, adding a team-high 10 home runs. Alec Burleson is the team’s best hitter with a .307 batting average.

Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 1-1 record, 2.70 ERA and 0.84 WHIP. He is coming off a quality start against the White sox, with one earned run across 5 innings pitched. This will be his first career start against the Cubs.

Chicago Cubs Preview

The Chicago Cubs have a 46-32 record this season and are sitting on the first place of the NL Central. The Cubs have a 21-17 road record and are 39-31 in over/under. They are coming off a 2-8 road defeat by the Cardinals, and are 1-4 in their last 5 games. Over is 5-0 in their last 5 games, and are playing the Astros and the Guardians next.

The Cubs have a .254 batting average this season, .324 OBP and .442 Slugging percentage. Chicago’s pitching staff has a 3.89 ERA and 1.26 WHIP. Nico Hoerner leads the Cubs with 82 hits and he is the team’s best hitter with a .288 batting average. Seiya Suzuki leads the team in RBI, with 64.

Jameson Taillon (R) is the projected starting pitcher for the Cubs, and he has a 7-4 record, 3.84 ERA and 1.04 WHIP. He has been weaker on the road, with a 4.31 ERA across seven road starts, and he was torched in his last start, having given up 5 runs across 4 innings pitched in a 7-8 loss to the Brewers. Jameson Taillon has a record of 6-2 with an ERA of 3.33 and 79 strikeouts in 16 appearances versus the Cardinals in his career.

Why the St. Louis Cardinals will win

The Cardinals have won each of their last seven night games against National League opponents following a win.
The Cubs have lost each of their last seven night games at Busch Stadium following a loss.
The Cardinals have covered the run line in each of their last seven night games against National League opponents following a win.
The Cubs have failed to cover the run line in each of their last six games against National League opponents after playing the previous day.
The Cubs have lost the first inning in three of their last four road games against NL Central opponents.
The Cubs have trailed after 3 innings in three of their last four games against National League opponents that held a winning record.
The Cubs have trailed after 5 innings in eight of their last nine road games against National League opponents that held a winning record.

Why the Chicago Cubs will win

The Cubs have won 18 of their last 19 games following a road loss.
The Cardinals have lost four of their last five games against the Cubs following a win.
The Cubs have covered the run line in each of their last eight road games following a road loss.
The Cardinals have failed to cover the run line in seven of their last eight games following a home win.
The Cubs have led after 5 innings in 11 of their last 14 night games against NL Central opponents.
The Cubs have won the first inning in three of their last four games as favorites.

Total Runs Facts

Seven of the last eight games between the Cubs and Cardinals have gone OVER the total runs line.
Each of the Cubs’ last five games have gone OVER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last six night games against National League opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cubs’ last four night games.

Matchup/League Facts

The Cardinals rank 2nd in the league for walks allowed this season (213).
The Cardinals rank T28th in the league for triples this season (4).
The Cubs rank 2nd in the league for runs scored this season (419).
The Cubs rank 2nd in the league for RBIs this season (411).

Chicago Cubs vs Saint Louis Cardinals Prediction

The Cubsare 4-2 in their last 6 overall meetings against the Cardinals, but the Cardinals are 3-1 in their last 4 meetings in Saint Louis. Over is 6-1 in their last 7 meetings.
In this Chicago Cubs vs Saint Louis Cardinals Prediction, the Cubs are coming as -120 road favorites. Chicago has a better overall record and has been above average on the road, but Saint Louis has been strong at home, with 25 wins. Both teams have very potent offenses, as they average 10.3 runs per game combined, but they are even better against right-handed pitching, averaging 10.6 runs combined. The Cardinals have scored 6+ runs in four of their last five games and the Cubs are 5-0 to the over. Yesterday’s game had 10 total runs, so take the over 9 in this one.

Nikos Lagouretos's Pick: Over 9