Seattle Mariners vs Los Angeles Angels Prediction 4/5/2026 Today’s MLB Picks

The Seattle Mariners and the Los Angeles Angels meet Sunday in MLB action from Angels Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. Los Angeles Angels prediction.

Starting Pitching Matchup

The Seattle Mariners will start Luis Castillo here and Castillo is 0-0 with a 0.00 ERA and 7 strikeouts this season. In his last five starts against the Angels, Castillo is 2-1 with a 1.50 ERA and 28 strikeouts. Ryan Johnson will start for the angels here and is 0-1 with a 16.20 ERA and 2 strikeouts this season. This will be Johnson’s first career start against the Mariners.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from a 1-0 loss at the hands of the Angels on Saturday to drop to 4-5 this season. After this series, the Mariners will head on the road for a series against the Texas Rangers.

Mariners Drop 3 Of Last 4

Brendan Donovan has 10 hits with 2 doubles, 2 home runs and 4 RBIs while Luke Raley has 3 home runs and 6 RBIs this season. Cole Young’s added 9 hits with 2 doubles, a triple, a home run and 5 RBIs and Cal Raleigh has 4 hits with a double and 4 RBIs as well this season. Randy Arozarena has 9 hits with 3 doubles and 2 RBIs as well on the year.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to build on their win over the Mariners from Saturday to sit at 4-5 on the year. After this series, the Angels will take on the Atlanta Braves at home.

Angels Looking To Earn Series Win

Nolan Schanuel has 7 hits with a pair of homers and 5 RBIs while Mike Trout’s added 6 hits with 2 home runs and 3 RBIs this season. Zach Neto’s also added 8 hits with a double, 3 homers and 4 RBIs and Jo Adell has 8 hits with 2 RBIs as well this season. Oswald Peraza has 7 hits with a double, a home run and two RBIs and Jorge Soler has 5 hits with a double and 5 RBIs well this season.

Seattle Mariners @ Los Angeles Angels Betting Trends: April 5, 2026

• Probable Starting Pitcher: Ryan Johnson      Record this season: 0-1      ERA: 16.20
• Home Record: 0-0
• Last 5 against Mariners: 0-0

Why the Los Angeles Angels will win

• The Mariners have lost seven of their last nine games as favorites after playing the previous day.
• The underdogs have won 11 of the Mariners’ last 15 games at Angel Stadium of Anaheim.
• The Mariners have failed to cover the run line in nine of their last 10 road games against American League opponents that held a losing record.
• The underdogs have covered the run line in nine of the Mariners’ last 11 games at Angel Stadium of Anaheim.
• The Mariners have trailed after 3 innings in four of their last five road games against American League opponents that held a losing record.
• The Mariners have lost the first inning in three of their last four games.
• The Mariners have trailed after 5 innings in three of their last four games.

• Probable Starting Pitcher: Luis Castillo      Record this season: 0-0      ERA: 0.00
• Road Record: 0-0
• Last 5 against Angels: 2-1

Why the Seattle Mariners will win

• The Mariners have won 11 of their last 12 games against AL West opponents following a loss.
• The Angels have lost each of their last five day games after playing the previous day.
• The Angels have failed to cover the run line in seven of their last eight day games following a win.
• The Mariners have covered the run line in each of their last four road games following a loss.
• The Mariners have led after 3 innings in five of their last six day games against the Angels.
• The Mariners have won the first inning in three of their last four day games against American League opponents that held a losing record.
• The Mariners have led after 5 innings in five of their last six day games against opponents that held a losing record.

Total Runs Facts

• Each of the Angels’ last six home games against AL West opponents have gone UNDER the total runs line.
• Each of the Mariners’ last four day games against AL West opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Mariners’ last six day games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Angels’ last six day games at Angel Stadium of Anaheim.

Los Angeles Angels Player Prop Facts

• Jo Adell has hit a home run in three of the Angels’ last four day games against AL West opponents that held a losing record.
• Nolan Schanuel has recorded at least one hit in each of his last eight appearances in day games.
• Zach Neto ranks T4th in the league in Home Runs (3) this season.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit at least one home run in four of the Mariners’ last five day games against opponents that held a losing record.
• Victor Robles has recorded at least one hit in each of his last nine appearances in day games against teams that held a losing record.
• Luis Castillo has recorded a win in six of his last eight appearances in day games against AL teams that held a losing record.
• Luke Raley ranks T4th in the league in Home Runs (3) this season.

Matchup/League Facts

• The Angels rank 30th in the league for strikeouts against this season (99).
• The Angels rank 30th in the league for walks allowed this season (48).
• The Mariners rank 2nd in the league for walks allowed this season (18).
• The Mariners rank 28th in the league for batting average this season (.199).

Seattle Mariners vs. Los Angeles Angels Prediction

I’m on the Mariners in this one. I get why someone would want to look at the Angels as a home dog, but realistically, they’ve only scored two runs in this series and Castillo’s coming to the bump for Seattle with solid career numbers against the Halos. I don’t trust Ryan Johnson in this matchup as I don’t think the Angels can back him up offensively and in the end, I think the Angels just end up falling flat once again. Give me Seattle.

Chris Ruffolo's Pick: Seattle -170