Seattle Mariners vs Houston Astros Prediction 5/22/25 MLB Picks

The Seattle Mariners are visiting Houston Astros on Thursday, May 22nd at the Daikin Park in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Seattle Mariners vs Houston Astros Prediction. We will examine:

The Houston Astros recent form and player performance

The Seattle Mariners recent form and player performance

Recent betting trends and streaks involving the Houston Astros

Recent betting trends and streaks involving the Seattle Mariners

Recent betting trends in games played between the Seattle Mariners vs Houston Astros

A summary that ties it all together and produces a favorable betting outcome for A Seattle Mariners vs Houston Astros game

Houston Astros Preview

The Houston Astros have a 25-24 record this season and are sitting on the second place of the AL West. The Astros have a 15-9 home record and 20-27 in over/under. They are coming off a 4-8 road defeat by the Tampa Bay Rays, and have back-to-back losses. Under is 7-2 in their last 9 games, and they are playing the Athletics and the Rays next.

The Astros have a .246 batting average this season, .317 OBP and .378 slugging percentage. Houston’s pitching staff has a 3.48 ERA and 1.14 WHIP. Jeremy Pena leads the Astros with 55 hits, while Isaac Paredes leads the team in RBI with 28, adding a team-high 10 home runs. Jake Meyers is the team’s best hitter, with a .306 batting average.

Lance McCullers Jr. (R) will take the mound for the Astros, and he has a 0-1 record, 7.88 ERA and 2.13 WHIP. He got lit up in his only home start of the season, with 7 earned runs in just 0.1 inning pitched, but he is coming off a shutout performance in 4 innings pitched against the Rangers. Lance McCullers Jr. has a 10-3 record with an ERA of 2.80 and 120 strikeouts in 18 appearances against the Mariners in his career.

Seattle Mariners Preview

The Seattle Mariners have a 28-20 record this season and are sitting on the first place of the AL West. The Mariners have a 15-9 road record and 26-20 in over/under They are coming off a 6-5 road victory over the Chicago White Sox, and are 5-1 in their last 6 games. Under is 7-1 in their last 8 games and they are playing the Nationals and the Twins next.

The Mariners have a .236 batting average this season, .324 OBP and .399 Slugging percentage. Seattle’s pitching staff has a 3.62 ERA and 1.30 WHIP. Julio Rodriguez leads the Mariners with 45 hits, while JP Crawford is the team’s best hitter with a .269 batting average. Cal Raleigh leads the team both in RBI with 33, and in home runs with 16.

George Kirby (R) will take the mound for the Mariners, and this will be his first start of the season. Last season he had a 14-11 record, 3.53 ERA and 1.07 WHIP. George Kirby is 2-0 with an ERA of 1.55 and 37 strikeouts in 7 appearances against the Astros in his career.

Why the Houston Astros will win

• The Astros have won each of their last six games as underdogs against American League opponents following a loss.
• The Mariners have lost each of their last four games as favorites against the Astros following a road win.
• The Astros have covered the run line in each of their last 12 games as underdogs against American League opponents following a loss.
• The Mariners have failed to cover the run line in each of their last six games as favorites against the Astros following a road win.
• The Astros have led after 3 innings in four of their last five games as home underdogs against American League opponents.
• The Astros have led after 5 innings in four of their last five home games against AL West opponents that held a winning record.

Why the Seattle Mariners will win

• The Mariners have won seven of their last eight road games.
• The Astros have lost eight of their last nine games as home underdogs against AL West opponents.
• The Mariners have covered the run line each of their last 10 games at Daikin Park against teams that held a winning record.
• The Astros have failed to cover the run line in each of their last eight home games against the Mariners following a loss.
• The Mariners have won the first inning in each of their last five Thursday road games against American League opponents.
• The Mariners have led after 3 innings in each of their last six night games against the Astros at Daikin Park.
• The Astros have trailed after 5 innings in each of their last six home games against American League opponents that held a winning record.

Total Runs Facts

• Nine of the Astros’ last 10 games as underdogs have gone UNDER the total runs line.
• Seven of the Mariners’ last eight games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the last 11 games between the Mariners and Astros.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Mariners’ last six games at Daikin Park.

Matchup/League Facts

• The Astros rank 2nd in the league for opponent batting average this season (.213).
• The Astros rank 3rd in the league for hits allowed this season (337).
• The Mariners rank T2nd in the league for walks this season (191).
• The Mariners rank 28th in the league for doubles this season (63).

Seattle Mariners vs Houston Astros Prediction

The Mariners are 5-2 in their last 7 meetings against the Astros, and are 4-1 in their last 5 visits in Houston. Under is 5-3-2 in their last 10 meetings.

In this Seattle Mariners vs Houston Astros Prediction, the Mariners are coming as -140 road favorites. The Mariners are rightfully favored, as they have a better overall record, and have the same road record, as the Astros have at home. Astros have a better bullpen, but Kirby has been amazing against the Houston bats historically, and the Mariners have a superior batting average and are better against righties. I certainly trust Kirby more than I trust McCullers, so I will go with the Seattle Mariners on the moneyline in the first 5 innings of this game.