Seattle Mariners vs Houston Astros Prediction 5/12/2026 Today’s MLB Picks

In this article, we will formulate a Mariners vs Astros Prediction for this MLB matchup on Tuesday, May 12th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Preview

The Houston Astros have a 16-26 record this season and are sitting in the fifth place of the AL West. They have a 9-11 home record and are coming off a 1-3 loss at home against the Mariners. They will face the Rangers and the Twins next.

The Astros have a .258 batting average this season, .333 OBP and .425 Slugging percentage. Houston’s pitching staff has a 5.50 ERA and 1.58 WHIP. Yordan Alvarez is the team’s best hitter with a .314 batting average, also adding a team‑high 13 home runs. Christian Walker leads the team in RBI with 27.

Tatsuya Imai (R) is the projected starting pitcher for the Astros, and he has a 1-0 record, 7.27 ERA and 2.08 WHIP.

Seattle Mariners Preview

The Seattle Mariners have a 20-22 record this season and are sitting in the second place of the AL West. They have a 8-11 away record and are coming off a 3-1 win on the road against the Astros. They will face the Padres and the White Sox next.

The Mariners have a .229 batting average this season, .317 OBP and .376 Slugging percentage. Seattle’s pitching staff has a 3.71 ERA and 1.23 WHIP. Randy Arozarena is the team’s best hitter with a .285 batting average. Luke Raley leads the team in RBI with 23, also adding a team‑high 8 home runs.

Bryan Woo (R) is the projected starting pitcher for the Mariners, and he has a 2-2 record, 4.02 ERA and 1.00 WHIP.

Seattle Mariners @ Houston Astros Betting Trends: May 12, 2026

• Probable Starting Pitcher: Tatsuya Imai      Record this season: 1-0      ERA: 7.27
• Home Record: 0-0
• Last 5 against Mariners: 0-0

Why the Houston Astros will win

• The Mariners have lost six of their last seven games as favorites against American League opponents following a road win.
• The Astros have won four of their last five games as underdogs following a home loss.
• The Mariners have failed to cover the run line in 10 of their last 11 night games following a win.
• The Astros have covered the run line in four of their last five home games against American League opponents that held a losing record.
• The Astros have won the first inning in three of their last four home games against American League opponents that held a losing record.
• The Astros have led after 3 innings in six of their last eight home games against opponents that held a losing record.
• The Mariners have trailed after 5 innings in four of their last five games as road favorites against AL West opponents.

• Probable Starting Pitcher: Bryan Woo      Record this season: 2-2      ERA: 4.02
• Road Record: 0-2
• Last 5 against Astros: 2-2

Why the Seattle Mariners will win

• The Mariners have won each of their last eight games against the Astros.
• The Astros have lost each of their last seven games against the Mariners following a loss.
• The Astros have failed to cover the run line in each of their last seven night games against the Mariners at Daikin Park following a home loss.
• The Mariners have covered the run line in seven of their last eight games against the Astros.
• The Mariners have won the first inning in four of their last five games against the Astros.
• The Mariners have led after 3 innings in each of their last five games at Daikin Park.
• The Astros have trailed after 5 innings in each of their last six night games at Daikin Park against AL West opponents.

Total Runs Facts

• Eight of the Astros’ last nine home games against American League opponents have gone OVER the total runs line.
• Seven of the Mariners’ last eight games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Mariners’ last 11 games against AL West opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last four games.

Houston Astros Player Prop Facts

• Isaac Paredes has recorded at least one hit in each of his last seven appearances against AL West opponents.
• Jeremy Pena has hit a home run in two of his last three appearances with the Astros as home underdogs.
• Yordan Alvarez ranks T3rd in the league in Hits (49) this season.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit a home run in three of the Mariners’ last four games against AL West opponents.
• Julio Rodriguez has recorded at least one hit in each of the Mariners’ last 11 games against AL West opponents.
• Randy Arozarena ranks T10th in the league in Steals (9) this season.

Matchup/League Facts

• The Astros rank T1st in the league for doubles this season (77).
• The Astros rank 30th in the league for ERA this season (5.50).
• The Mariners rank 1st in the league for walks allowed this season (102).
• The Mariners rank 28th in the league for doubles this season (54).

Mariners vs Astros Prediction

The Mariners have won their last 8 meetings against the Astros and have won their last three visits in Houston. Over is 7-3 in their last 10 meetings.

In this Mariners vs Astros Prediction, the Mariners are coming as -155 road favorites. The Mariners have been dominating the Astros this season, having won all of their five meetings, with their last three meetings having a combined 15-4 score. The Astros have lost three straight, having scored just two runs in that span and will have to face Bryan Woo today, so things are not looking good. The bullpen difference is also huge, as the Mariners rank third in bullpen ERA, while the Astros are dead last, so keep it simple and take the Mariners on the moneyline in this one.

Nikos Lagouretos's Pick: Seattle Mariners ML