Seattle Mariners vs Chicago White Sox Prediction 5/21/25 MLB Picks

The Seattle Mariners and the Chicago White Sox meet Wednesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Seattle Mariners will send out Logan Evans for the start here, and Evans is 2-1 with a 2.57 ERA and 14 strikeouts this season. This will be Evans’ first career start against the White Sox. Shane Smith will get the start for the White Sox here and is 1-3 with a 2.05 ERA and 43 strikeouts this season. This will be Smith’s first career start against Seattle.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from their 1-0 loss at the hands of the White Sox in Tuesday’s matchup to fall to 27-20 on the year. After this series, the Mariners will head on the road for a division series against the Houston Astros.

Mariners Have Four-Game Win Streak Snapped

Jorge Polanco has 37 hits, including 10 home runs and 30 RBIs, while Cal Raleigh has 41 hits with 9 doubles, a team-high 15 home runs, and 32 RBIs. Randy Arozarena has 37 hits with 10 doubles, 6 home runs, 21 RBIs, and 9 stolen bases. Julio Rodriguez also has 44 hits with a pair of triples, 8 home runs, 25 RBIs, and 5 stolen bases. Dylan Moore has 7 homers and 7 stolen bases as well this season. Rowdy Tellez has also added 8 home runs and 22 RBIs, while J.P. Crawford has 43 hits with 5 doubles, 4 home runs, and 19 RBIs.

Why the Seattle Mariners will win

• The White Sox have lost eight of their last nine games against teams that held a winning record.
• The Mariners have won seven of their last eight games against American League opponents following a road loss.
• The Mariners have covered the run line in each of their last six day games against the White Sox following a loss.
• The White Sox have failed to cover the run line in seven of their last eight games against the Mariners following a win.

Seattle Mariners Player Prop Facts

• J.P. Crawford has recorded at least one Single in each of the Mariners’ last six road games against AL opponents.
• J.P. Crawford has recorded at least one hit in each of his last 12 road appearances against AL opponents.
• Dylan Moore has hit a home run in two of his last three appearances in day games against AL teams that held a losing record.
• Victor Robles has recorded a Double in each of the Mariners’ last three day games against AL Central opponents that held a losing record.
• Victor Robles has recorded at least one RBI in each of his last four appearances in day games against teams that held a losing record.
• Victor Robles has scored at least one run in each of his last six appearances with the Mariners as road favorites.
• Cal Raleigh ranks T4th in the league in Home Runs (15) this season.

Chicago White Sox Recap

The Chicago White Sox will be looking to build on their win over the Mariners from Tuesday’s matchup to improve to 15-34 on the year. After this series, the White Sox will square off against the Texas Rangers at home.

White Sox Snap Five-Game Losing Streak

Lenyn Sosa leads the White Sox with 43 hits, including 8 doubles and 11 RBIs. Andrew Benintendi has 19 hits, including 5 home runs, 12 RBIs, and a .224 batting average, while Miguel Vargas has a team-high 10 doubles and 21 RBIs. Brooks Baldwin has also added 16 RBIs, while Luis Robert Jr. has a team-high 17 stolen bases along with 17 RBIs so far this season. Andrew Vaughn has 5 home runs and 19 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

• The underdogs have won five of the White Sox’s last six games at Rate Field.
• The Mariners have lost five of their last six games as favorites against AL Central opponents.
• The Mariners have failed to cover the run line in eight of their last nine games as favorites against AL Central opponents.
• The White Sox have covered the run line in eight of their last nine day games against AL West opponents following a win.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit at least one home run in two of the White Sox’s last three day games against opponents that held a winning record.
• Miguel Vargas has recorded at least one RBI in each of the White Sox’s last four day games.
• Andrew Vaughn has recorded a Single in four of his last five appearances against the Mariners after playing the previous day.
• Andrew Benintendi has recorded at least one hit in 13 of his last 14 appearances with his team as an underdog against the Mariners.
• Andrew Benintendi has scored a run in each of his last five appearances.
• Luis Robert ranks 2nd in the league in Steals (17) this season.

Total Runs Facts

• Each of the Mariners’ last seven games have gone UNDER the total runs line.
• Each of the White Sox’s last four home games have gone UNDER the total runs line.

Seattle Mariners vs. Chicago White Sox Prediction

I’m on the under here. What this boils down to for me here is that I don’t trust the White Sox offensively on a good day, and I don’t trust them really to do a whole lot of damage here. On the other side, Shane Smith has been the bright spot of this White Sox rotation, and I think this could end up being a low-scoring game just because of a lack of offense on both sides and in what could be a first-to-3-wins kind of game. Give me the under.