Seattle Mariners vs Chicago White Sox Prediction 5/20/25 MLB Picks

The Seattle Mariners and the Chicago White Sox meet Tuesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Seattle Mariners did not have a starting pitcher announced at the time that this article was posted. The Chicago White Sox will send out Bryse Wilson for the start here, and Wilson is 0-2 with a 6.00 ERA and 19 strikeouts this season. This will be Wilson’s first career start against the Mariners.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to build on their 5-1 series-opening win over the White Sox from Monday’s matchup to improve to 27-19 on the year. After this series, the Mariners will head on the road for a division series against the Houston Astros.

Mariners Win Four In A Row

Jorge Polanco has 36 hits, including 10 home runs and 29 RBIs, while Cal Raleigh has 40 hits with 8 doubles, a team-high 15 home runs, and 32 RBIs. Randy Arozarena has 37 hits with 10 doubles, 6 home runs, 21 RBIs, and 9 stolen bases. Julio Rodriguez also has 43 hits with a pair of triples, 7 home runs, 21 RBIs, and 5 stolen bases. Dylan Moore has 7 homers and 7 stolen bases as well this season. Rowdy Tellez has also added 8 home runs and 22 RBIs, while J.P. Crawford has 41 hits with 5 doubles, 4 home runs, and 19 RBIs.

Why the Seattle Mariners will win

• The White Sox have lost each of their last eight games against teams that held a winning record.
• The Mariners have won each of their last six road games.
• The road team has covered the run line in each of the last seven games between the Mariners and White Sox.
• The White Sox have failed to cover the run line each of their last five games against teams that held a winning record.

Seattle Mariners Player Prop Facts

• Julio Rodriguez has hit a home run in each of his last two appearances with the Mariners as favorites against the White Sox.
• Rowdy Tellez has recorded at least one RBI in six of the Mariners’ last seven games as road favorites against AL opponents.
• Dylan Moore has recorded a Single in each of his last six appearances with the Mariners as road favorites.
• J.P. Crawford has scored at least one run in each of his last nine appearances with the Mariners as road favorites against AL Central opponents.
• J.P. Crawford has recorded at least one hit in each of his last 11 road appearances against AL opponents.
• Victor Robles has recorded a Double in three of his last four appearances against AL Central opponents.
• Cal Raleigh ranks T3rd in the league in Home Runs (15) this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from their loss at the hands of the Mariners in Monday’s matchup, falling to 14-34 on the year. After this series, the White Sox will take on the Texas Rangers at home.

White Sox Lose 5th Straight

Lenyn Sosa leads the White Sox with 41 hits, including 7 doubles and 11 RBIs. Andrew Benintendi has 19 hits, including 5 home runs, 12 RBIs, and a .224 batting average, while Miguel Vargas has a team-high 10 doubles and 21 RBIs. Brooks Baldwin has also added 16 RBIs, while Luis Robert Jr. has a team-high 17 stolen bases along with 17 RBIs so far this season. Andrew Vaughn has 5 home runs and 18 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

• The White Sox have won four of their last five games as home underdogs following a loss.
• The Mariners have lost four of their last five games as favorites against AL Central opponents.
• The Mariners have failed to cover the run line in seven of their last eight night games against AL Central opponents.
• The underdogs have covered the run line in 11 of the Mariners’ last 13 games.

Chicago White Sox Player Prop Facts

• Andrew Vaughn has recorded an RBI in each of the White Sox’s last four home games.
• Luis Robert has hit at least one home run in five of the White Sox’s last 10 night games against AL West opponents that held a winning record.
• Andrew Benintendi has scored a run in each of his last five appearances.
• Andrew Vaughn has recorded a Single in each of his last four appearances against the Mariners after playing the previous day.
• Andrew Benintendi has recorded at least one hit in 13 of his last 14 appearances with his team as an underdog against the Mariners.

Total Runs Facts

• Each of the Mariners’ last six games have gone UNDER the total runs line.
• Each of the White Sox’s last four night games against American League opponents have gone UNDER the total runs line.

Seattle Mariners vs. Chicago White Sox Prediction

I’m on the Mariners -1.5 here. It would be nice to know who the Mariners are throwing out for the start here, but I think that we’re at a point with the White Sox where it doesn’t matter who the other team is starting here; Chicago is on auto-fade until further notice. The offense continues to be lacklustre for the White Sox, and while Seattle’s cooled off in some of their recent outings, I still think the Mariners are miles ahead of the better team in this matchup, so I’ll roll with the Mariners -1.5 for another sizeable win in this one.