Seattle Mariners vs Chicago White Sox Prediction 5/19/25 MLB Picks

The Seattle Mariners and the Chicago White Sox meet Monday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Seattle Mariners will start Luis Castillo here, and Castillo is 3-3 with a 3.65 ERA and 39 strikeouts this season. In his career, Castillo is 1-0 with a 2.33 ERA and 23 strikeouts against the White Sox. The Chicago White Sox will start Davis Martin here, and Martin is 2-4 with a 3.65 ERA and 33 strikeouts this season. This will be Martin’s first career start against the Mariners.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to build on their 6-1 win over the San Diego Padres in Sunday’s series finale to improve to 26-19 on the year. After this series, the Mariners will head on the road for a division series against the Houston Astros.

Mariners Win Three Straight

Jorge Polanco has 36 hits, including 10 home runs and 29 RBIs, while Cal Raleigh has 40 hits with 8 doubles, a team-high 15 home runs, and 32 RBIs. Randy Arozarena has 37 hits with 10 doubles, 6 home runs, 21 RBIs, and 9 stolen bases. Julio Rodriguez also has 43 hits with a pair of triples, 7 home runs, 21 RBIs, and 5 stolen bases. Dylan Moore has 7 homers and 7 stolen bases as well this season. Rowdy Tellez has also added 8 home runs and 22 RBIs, while J.P. Crawford has 41 hits with 5 doubles, 4 home runs, and 19 RBIs.

Why the Seattle Mariners will win

• The White Sox have lost each of their last seven games against teams that held a winning record.
• The road team has won 10 of the Mariners’ last 11 games.
• The road team has covered the run line in each of the last six games between the Mariners and White Sox.
• The White Sox have failed to cover the run line each of their last four games against teams that held a winning record.

Seattle Mariners Player Prop Facts

• Jorge Polanco has hit at least one home run in three of his last four appearances at Rate Field against AL opponents that held a losing record.
• Rowdy Tellez has recorded at least one RBI in each of the Mariners’ last six games as road favorites against AL opponents.
• Randy Arozarena has recorded at least one Single in each of his last six road appearances against opponents that held a losing record.
• J.P. Crawford has scored at least one run in each of his last eight appearances with the Mariners as road favorites against AL Central opponents.
• Luis Castillo has recorded a win in four of his last five appearances against AL Central opponents that held a losing record.
• Luis Castillo has recorded six or more strikeouts in each of his last seven Monday appearances.
• J.P. Crawford has recorded at least one hit in each of his last 10 road appearances against AL opponents.
• Victor Robles has recorded a Double in three of the Mariners’ last four games against AL Central opponents that held a losing record.
• Cal Raleigh ranks T2nd in the league in Home Runs (15) this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from a 6-2 loss at the hands of the Chicago Cubs last time out to slip to 14-33 on the year. After this series, the White Sox will take on the Texas Rangers at home.

White Sox Drop Four In A Row

Lenyn Sosa leads the White Sox with 41 hits, including 7 doubles and 11 RBIs. Andrew Benintendi has 19 hits, including 5 home runs, 12 RBIs, and a .224 batting average, while Miguel Vargas has a team-high 10 doubles and 21 RBIs. Brooks Baldwin has also added 16 RBIs, while Luis Robert Jr. has a team-high 17 stolen bases along with 17 RBIs so far this season. Andrew Vaughn has 5 home runs and 18 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

• The White Sox have won each of their last four games as home underdogs following a loss.
• The Mariners have lost each of their last four games as favorites against AL Central opponents.
• The Mariners have failed to cover the run line in each of their last seven games as favorites against AL Central opponents.
• The underdogs have covered the run line in 11 of the Mariners’ last 12 games.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit at least one home run in two of the White Sox’s last three games as underdogs.
• Miguel Vargas has recorded at least one RBI in each of the White Sox’s last four games.
• Miguel Vargas has recorded at least one Single in six of the White Sox’s last seven games against AL West opponents.
• Andrew Vaughn has recorded at least one hit in each of his last 11 Monday appearances with the White Sox as underdogs.
• Andrew Benintendi has scored a run in each of his last five appearances.
• Luis Robert ranks 1st in the league in Steals (17) this season.

Total Runs Facts

• Thirteen of the Mariners’ last 14 games as favorites have gone OVER the total runs line.
• Five of the White Sox’s last six night games after playing the previous day have gone UNDER the total runs line.

Seattle Mariners vs. Chicago White Sox Prediction

I’m on the Mariners -1.5 here. I get the case to be made for a home underdog in some spots, but the White Sox just are not a team I want to take a stab at right now in any way, shape, or form. The Mariners have some huge confidence after their sweep of the Padres, and while Castillo’s struggled on the road this season, this is just a huge mismatch in favor of the Mariners, so give me Seattle -1.5 in this one.