San Francisco Giants vs St. Louis Cardinals Prediction 9/16/2026 Today’s MLB Picks

The San Francisco Giants and the St. Louis Cardinals will meet on Wednesday afternoon in a National League matchup at Busch Stadium in St. Louis, Missouri. Let’s take a look at this matchup from a betting perspective.

San Francisco Giants Betting Preview

The San Francisco Giants enter Wednesday’s contest with a 63–89 overall record (4th in the National League West) and an abysmal 27–50 mark on the road. The Giants offense has been inconsistent this season. San Francisco has compiled 642 runs scored (23rd in MLB), 251 doubles, 173 home runs and a .247 team batting average which ranks 14th in Major League Baseball.

The Giants arrive at tomorrow’s game in below average form. San Francisco has lost four of the team’s last six games played this season, including a 7–5 loss to the San Diego Padres four days ago.

The San Francisco Giants will turn to right hander Anthony Molina in this game. In three starts made this season, Molina has compiled a 2-1 win-loss record, a 5.24 ERA, a 1.25 WHIP and 19 strikeouts in 22.1 innings pitched. Anthony Molina arrives at this contest in poor form, allowing seven earned runs while surrendering nine hits and two walks across three innings pitched in the San Diego Padres 7-5 victory over the San Francisco Giants last week. Molina will look to build upon that strong performance in tomorrow afternoon’s matchup with the Cardinals.

The San Francisco Giants lineup features Rafael Devers and Jung Hoo Lee. Rafael Devers has compiled a .258 batting average, 37 home runs (8th in MLB), 98 RBIs, and an .865 OPS which ranks 12th in Major League Baseball. Jung Hoo Lee has tallied a .276 batting average (11th in MLB), 9 home runs, 55 RBIs, 28 doubles, 26 walks, 12 stolen bases and a .718 OPS.                                                               

St. Louis Cardinals Betting Preview

The St. Louis Cardinals enter Wednesday’s contest with a 72-75 overall record (4th in the National League Central) and a 37-39 mark at home. The Cardinals arrive at this contest in above average form, winning three of the team’s last five games.

The Cardinals will start left hander Matthew Liberatore in this contest. In 29 starts made in 2026, Liberatore has compiled a 5-14 record, a 5.53 ERA, a 1.49 WHIP and 146 strikeouts in 143.1 innings pitched. Matthew Liberatore has struggled recently, allowing five earned runs or more in two of his last three starts made this season.

Shifting our focus to the St. Louis offense, the Cardinals lineup features Alec Burleson and Jordan Walker. Burleson has amassed a .283 batting average and 104 RBIs, while Joran Walker has tallied 28 home runs and 100 RBIs.   

Why the San Francisco Giants will win.

• Starting pitching. Anthony Molina has compiled a 2-1 win-loss record, a 5.24 ERA and a 0.88 WHIP and a 1.25 WHIP across three starts made this season.

• Motivation. The San Francisco Giants have lost four of the team’s last six games.    

Why the St. Louis Cardinals will win.

• Home field advantage. The Cardinals have played competitive baseball at Busch Stadium this season.

• Offensive leaders. Alec Burleson and Jordan Walker have been key contributors for the St. Louis Cardinals in 2026.

San Francisco Giants vs. St. Louis Cardinals Prediction

In my view, the way to go in this matchup is the total rather than a side. Why? Cardinals hurler Matthew Liberatore has struggled recently, allowing five earned runs or more in two of his last three starts made this season. Similarly, Giants starter Anthony Molina performed poorly in his most recent outing, allowing seven earned runs while surrendering nine hits and two walks across three innings pitched in the San Diego Padres 7-5 victory over the San Francisco Giants last week. With that said, I envision a contest where both offenses flourish. I am backing over 7.5 runs in this game.

Hans Geevers's Pick: Over 7.5