San Francisco Giants vs Detroit Tigers Prediction 5/28/25 MLB Picks

In this article, we will formulate a Giants vs Tigers prediction for this MLB game on Wednesday, May 28, at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Betting Preview

The San Francisco Giants (31-24, 14-15 Away) are currently on a three-series road trip on which they beat the Washington Nationals but lost the opening two games against the Detroit Tigers, and now hope to avoid being swept. In last night’s 3-1 defeat, Logan Webb took the loss after allowing three runs on seven hits with ten strikeouts and one walk in 7.0 innings. San Francisco lost Game 1 of this series by an identical 3-1 result.

This year, the Giants average 4.41 runs per game (11th in the MLB) on a .231/.308/.376 triple-slash. When it comes to pitching, the Giants’ staff has a 3.25 ERA (3rd) and 1.20 WHIP (10th). Wilmer Flores leads the Giants with a .259 batting average, ten home runs, and 45 RBI this season.

The projected starting pitcher for the Giants is Landen Roupp, who is 3-3 in ten starts this season, with a 3.63 ERA and 1.40 WHIP in 52.0 innings.

Detroit Tigers Betting Preview

The Detroit Tigers (36-20, 20-8 Home) returned home from a series win over the St. Louis Cardinals and a loss to the Cleveland Guardians on the road, and opened the current one against the San Francisco Giants with a pair of identical 3-1 wins. In Game 2 victory, Riley Greene led the offense with two RBI, while Jack Flaherty got the win after allowing no runs on two hits with eight strikeouts and one walk across 6.0 innings of work.

This season, the Tigers average 5.11 runs per game (4th in the MLB) on a .253/.326/.410 triple-slash. When it comes to pitching, the Tigers’ staff has a 3.27 ERA (4th) and 1.15 WHIP (1st). Spencer Torkelson leads the Tigers with a .238 batting average, 13 home runs, and 40 RBI this season.

Jackson Jobe will take the mound for the Tigers on Wednesday. The 22-year-old right-hander has a 4-1 record in nine starts this year with a 4.06 ERA and 1.42 WHIP in 44.1 innings.

Total Runs Facts

• Eight of the Giants’ last nine road games have gone UNDER the total runs line.
• Each of the Tigers’ last five day games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last five day games at Comerica Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 12 of the Giants’ last 15 games as underdogs against AL Central opponents.

Matchup/League Facts

• The Tigers rank 3rd in the league for opponent batting average this season (.224).
• The Tigers rank 4th in the league for runs scored this season (284).
• The Giants are one of only five teams in the league to rank top 10 in both strikeouts and walks allowed this season.
• The Giants rank 6th in the league for ERA this season (3.25).

Giants vs Tigers Prediction

The Tigers won seven of the previous ten H2H encounters, including the last three. Seven of the last ten H2Hs went Under, including five of the previous six. Nine of San Francisco’s last ten games went Under, which was the case in seven of Detroit’s previous ten games. Those are all reasons to back Under in this one as well, but another reason is in a pitching matchup. Landen Roupp allowed just four runs in his last four starts, and he registered shutouts in the last two, while Jackson Jobe surrendered five runs in his previous three starts. I am backing these young pitchers to have another strong start here, so I am going with Under.