San Francisco Giants vs Chicago White Sox Prediction 06/29/2025 Picks

The San Francisco Giants and Chicago White Sox meet Sunday in MLB action at Rate Field. Here’s a San Francisco Giants vs Chicago White Sox Prediction. This article will include a San Francisco Giants vs Chicago White Sox Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 45-38 on the year and play the Diamondbacks, Athletics, and Phillies next. The San Francisco Giants are batting .231 on the season, have a .311 OBP, and a .372 slugging percentage. The San Francisco Giants pitching staff has a 3.36 ERA and a 1.24 WHIP. Heliot Ramos leads the San Francisco Giants with 87 hits and 44 RBI, while Jung Hoo Lee and Wilmer Flores have combined for 142 hits and 89 RBI. 

Justin Verlander gets the ball for the San Francisco Giants, and he is 0-5 with a 4.52 ERA and 52 strikeouts this season. Verlander is 23-14 with a 3.66 ERA and 290 strikeouts in his career against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 27-56 on the year and play the Dodgers, Rockies, and Blue Jays next. The Chicago White Sox are batting .220 on the season, have a .293 OBP, and a .343 slugging percentage. The Chicago White Sox pitching staff has a 4.12 ERA and a 1.39 WHIP. Miguel Vargas leads the Chicago White Sox with 68 hits and 34 RBI while Lenyn Sosa and Chase Meidroth have combined for 121 hits and 31 RBI.

Jonathan Cannon gets the ball for the Chicago White Sox, and he is 2-7 with a 4.66 ERA and 51 strikeouts this season. This will be Cannon’s second career game against the San Francisco Giants.

Why the Chicago White Sox will win

The Giants have lost four of their last five games as favorites.
The underdogs have won six of the Giants’ last eight games at Rate Field.
The Giants have failed to cover the run line in 18 of their last 20 day games against AL Central opponents that held a losing record.
The White Sox have covered the run line in five of their last six day games against National League opponents.

Why the San Francisco Giants will win

The White Sox have lost each of their last eight Sunday games against National League opponents that held a winning record.
The Giants have won each of their last six Sunday day games against teams that held a losing record.
The Giants have covered the run line in each of their last six road games following a loss.
The White Sox have failed to cover the run line in each of their last five games as underdogs following a win.

Chicago White Sox Player Prop Facts

Andrew Benintendi has hit a home run in each of the White Sox’s last three day games against NL opponents that held a winning record.
Josh Rojas has recorded at least one hit in each of his last seven appearances with his team as a home underdog against the Giants.

San Francisco Giants Player Prop Facts

Casey Schmitt has hit a home run in two of his last three road appearances.
Justin Verlander has recorded a win in four of his last five road appearances against AL Central opponents that held a losing record.
Matt Chapman has recorded at least one hit in 10 of his last 11 appearances.
Dominic Smith has recorded a Double in three of his last four road appearances against AL opponents that held a losing record.

San Francisco Giants vs Chicago White Sox Prediction

You can make a case for the White Sox, as the Giants have cooled off and haven’t been able to string together offense all of a sudden. Verlander also looks like a shell of himself and is no longer an automatic bet. However, I’ve been burned every time I’ve tried to take a shot with the White Sox this season, and it doesn’t matter if there’s a case to be made. More times than not, the White Sox will find a way to screw you over. I’m going to side with the Giants as a fade of the White Sox. They’ll find a way to lose.