Jun 19, 2025; San Francisco, California, USA; San Francisco Giants outfielder Heliot Ramos (17) beats the tag during the sixth inning against the Cleveland Guardians at Oracle Park. Mandatory Credit: Bob Kupbens-Imagn Images

San Francisco Giants vs Boston Red Sox Prediction 06/20/2025 Picks

Pick details

Boston (39-37) vs San Francisco (42-33)

June 20, 2025 at 10:15 PM EDT

The Line: Betting Odds: San Francisco -130 / Cleveland +110 — Over/Under: 7.5

(Get latest betting odds)

The Boston Red Sox are visiting the Athletics on Friday, June 20th at the Oracle Parkin the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Boston Red Sox vs Athletics Prediction. We will examine:
The Athletics recent form and player performance
The Boston Red Sox recent form and player performance
Recent betting trends and streaks involving the Athletics
Recent betting trends and streaks involving the Boston Red Sox
Recent betting trends in games played between the Boston Red Sox vs Athletics
A summary that ties it all together and produces a favorable betting outcome for the Boston Red Sox vs Athletics game

San Francisco Giants Preview

The San Francisco Giants have a 42-33 record this season and are sitting on the second place of the NL West. They have a 23-13 home record and are 34-39 in over/under. They are coming off a 2-1 home victory over the Guardians, which snapped their previous four-game winning streak. Under is 3-0-1 in their last 4 games, and are playing the White Sox and the Marlins next.

The Giants have a .232 batting average this season, .312 OBP and .374 Slugging percentage. San Francisco’s pitching staff has a 3.23 ERA and 1.21 WHIP.  Heliot Ramos leads the Giants with 78 hits and is the team’s best hitter, with a .281 batting average. Wilmer Flores leads the team in RBI with 53, while Matt Chapman leads the team in home runs, with 12.

Hayden Birdsong (R) is the projected starting pitcher for the Giants, and he has a 3-1 record, 2.79 ERA and 1.28 WHIP. He has been better at home, with a 1.78 ERA across eight home games and this will be his first career start against the Red Sox.

Boston Red Sox Preview

The Boston Red Sox have a 39-37 record this season and are sitting on the 4th place of the AL East. The Red Sox have a 17-20 road record and are 34-41 in over/under. They are coming off a 3-1 road victory over the Mariners and are 7-1 in their last 8 games. They are 7-1 to the under in their last 8 games and are playing the Blue Jays and the Angels next.

The Red Sox have a .248 batting average this season, .323 OBP and .416 slugging percentage. Boston’s pitching staff has a 3.93 ERA and 1.31 WHIP.  Jarren Duran leads the Red Sox with 82 hits, while Rafael Devers leads the team in RBI, with 58, in home runs, with 15, while being the team’s best hitter, with a .272 batting average.

Hunter Dobbins (R) is the projected starting pitcher for the Red Sox, and he has a 4-1 record, 3.74 ERA and 1.19 WHIP. He has been weaker on the road, with a 4.74 ERA across four road games, and he is coming off a shutout start against the Yankees in 6 innings pitched. This will be his first career start against the Giants.

Why the San Francisco Giants will win

The Red Sox have lost each of their last eight road games against National League opponents that held a winning record.
The Giants have won each of their last five games following a home win.
The Red Sox have failed to cover the run line in each of their last eight games against NL West opponents following a road win.
The Giants have covered the run line each of their last three night games against AL East opponents that held a winning record.
The Red Sox have trailed after 5 innings in each of their last four road games against National League opponents that held a winning record.
The Giants have won the first inning in each of their last four night games against AL East opponents.
The Red Sox have trailed after 3 innings in seven of their last eight road games against National League opponents that held a winning record.

Why the Boston Red Sox will win

The Giants have lost 10 of their last 11 games as favorites against AL East opponents following a home win.
The Red Sox have won seven of their last eight games.
The Giants have failed to cover the run line in each of their last 18 home games against AL East opponents following a win.
The underdogs have covered the run line in each of the Giants’ last 15 games at Oracle Park.
The Giants have trailed after 5 innings in each of their last six games against American League opponents that held a winning record.
The Giants have lost the first inning in three of their last four games against opponents that held a winning record.
The Giants have trailed after 3 innings in seven of their last eight home games against American League opponents that held a winning record.

Total Runs Facts

Each of the Giants’ last eight games against AL East opponents have gone OVER the total runs line.
Eight of the Red Sox’s last nine games against National League opponents have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last eight night games.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Red Sox’s last six games at Oracle Park.

Matchup/League Facts

The Giants rank 2nd in the league for home runs allowed this season (57).
The Giants rank 3rd in the league for ERA this season (3.23).
The Red Sox rank 1st in the league for doubles this season (141).
The Red Sox rank 28th in the league for strikeouts against this season (704).

Boston Red Sox vs San Francisco Giants Prediction

Both teams are tied 5-5 wins in their last 10 overall meetings, and the Giants are 2-1 in their last 3 meetings in San Francisco. Under is 6-0 in their last 6 meetings.
In this Cleveland Guardians vs San Francisco Giants Prediction, the Giants are coming as -130 home favorites. The Giants have a slightly better overall record, but they have been very strong at home, while the Red Sox are below average on the road. the Giants have the best bullpen in the league and both pitchers have been good this season, with a combined 6.53 ERA. Both teams have been struggling offensively lately, as the Giants have scored 2 runs in three straight games, while the Red Sox have scored 4 runs or less in their last 4 games. Their last six overall meetings had also gone under the total, so I expect a low-scoring affair tonight. Take the under 7.5 runs.

Nikos Lagouretos's Pick: Under 7.5

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