San Francisco Giants vs Arizona Diamondbacks Prediction 9/16/2025 Today’s MLB Picks

The San Francisco Giants and Arizona Diamondbacks meet Tuesday in MLB action at Chase Field. Here’s a San Francisco Giants vs Arizona Diamondbacks Prediction. This article will include a San Francisco Giants vs Arizona Diamondbacks Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 75-75 on the year and play the Dodgers, Cardinals, and Rockies next. The San Francisco Giants are batting .237 on the season, have a .312 OBP, and a .388 slugging percentage. The San Francisco Giants pitching staff has a 3.86 ERA and a 1.31 WHIP. Heliot Ramos leads the San Francisco Giants with 148 hits and 61 RBI, while Jung Hoo Lee and Willy Adames have combined for 265 hits and 134 RBI.

The San Francisco Giants didn’t announce a starting pitcher at the time of this writing.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 76-75 on the year and play the Phillies, Dodgers, and Padres next. The Arizona Diamondbacks are batting .251 on the season, have a .324 OBP, and a .435 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.45 ERA and a 1.32 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 160 hits and 97 RBI while Corbin Carroll and Lourdes Gurriel Jr. have combined for 259 hits and 156 RBI.

Eduardo Rodriguez gets the ball for the Arizona Diamondbacks, and he is 8-8 with a 4.98 ERA and 130 strikeouts this season. Rodriguez is 2-1 with a 4.29 ERA and 28 strikeouts in his career against the San Francisco Giants.

San Francisco Giants @ Arizona Diamondbacks Betting Trends: September 16, 2025

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 8-8      ERA: 4.98
• Home Record: 2-2
• Last 5 against Giants: 2-1

Why the Arizona Diamondbacks will win

• The Diamondbacks have won seven of their last eight night games following a win.
• The Giants have lost 10 of their last 12 games against NL West opponents that held a winning record.
• The Diamondbacks have covered the run line in each of their last five games.
• The Giants have failed to cover the run line in each of their last four games against National League opponents after playing the previous day.
• The Giants have trailed after 5 innings in five of their last six games against NL West opponents that held a winning record.

• Probable Starting Pitcher: TBD

Why the San Francisco Giants will win

• The Diamondbacks have lost seven of their last eight Tuesday night games against NL West opponents.
• The Giants have won four of their last five night games against National League opponents that held a winning record.
• The Giants have covered the run line in each of their last four games against National League opponents following a road loss.
• The Diamondbacks have failed to cover the run line in each of their last three night games against NL West opponents following a home win.

Total Runs Facts

• Six of the Giants’ last eight night games against NL West opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last nine home games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last four night games against NL West opponents.

Arizona Diamondbacks Player Prop Facts

• Lourdes Gurriel Jr. has recorded at least one hit in 23 of his last 24 appearances against the Giants.
• Eduardo Rodriguez has recorded six or more strikeouts in three of his four previous appearances against the Giants.
• Eduardo Rodriguez has recorded a win in each of his last three appearances against NL West opponents.
• Corbin Carroll has hit a home run in three of the Diamondbacks’ last five home games against NL West opponents.
• Corbin Carroll has recorded a Double in four of the Diamondbacks’ last five games against NL opponents at Chase Field.

San Francisco Giants Player Prop Facts

• Patrick Bailey has hit a home run in three of the Giants’ last five night games.
• Wilmer Flores has recorded at least one hit in each of the Giants’ last nine Tuesday night games against opponents that held a winning record.

Matchup/League Facts

• The Diamondbacks rank T4th in the league for runs scored this season (751).
• The Diamondbacks rank 4th in the league for slugging percentage this season (.435).
• The Giants rank 27th in the league for doubles this season (222).
• The Giants rank 26th in the league for hits this season (1179).

San Francisco Giants vs Arizona Diamondbacks Prediction

The Giants pitching has been getting rocked over their last three games, and I don’t have confidence in a pitcher who hasn’t been named at the time of this writing. The Diamondbacks are starting to find the form, and the same can be said for Rodriguez, who has allowed 10 hits and 1 runs in his last 18.1 innings. Rodriguez has allowed 1 or fewer runs in 4 of his last 6 starts. Rodriguez also just held the Giants to 6.2 scoreless innings and is holding current hitters to a .232 allowed batting average and 22 strikeouts in 69 at bats. Give me the Diamondbacks.