San Francisco Giants vs Arizona Diamondbacks Prediction 9/15/2025 Today’s MLB Picks

The San Francisco Giants and Arizona Diamondbacks meet Monday in MLB action at Chase Field. Here’s a San Francisco Giants vs Arizona Diamondbacks Prediction. This article will include a San Francisco Giants vs Arizona Diamondbacks Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 75-74 on the year and play the Dodgers, Cardinals, and Rockies next. The San Francisco Giants are batting .238 on the season, have a .313 OBP, and a .390 slugging percentage. The San Francisco Giants pitching staff has a 3.84 ERA and a 1.30 WHIP. Heliot Ramos leads the San Francisco Giants with 148 hits and 61 RBI, while Jung Hoo Lee and Willy Adames have combined for 265 hits and 134 RBI.

Kai-Wei Teng gets the ball for the San Francisco Giants, and he is 2-4 with a 7.54 ERA and 28 strikeouts this season. This will be Teng’s second career game against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 75-75 on the year and play the Phillies, Dodgers, and Padres next. The Arizona Diamondbacks are batting .250 on the season, have a .323 OBP, and a .434 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.47 ERA and a 1.32 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 157 hits and 95 RBI while Corbin Carroll and Lourdes Gurriel Jr. have combined for 258 hits and 156 RBI.

Zac Gallen gets the ball for the Arizona Diamondbacks, and he is 11-14 with a 4.84 ERA and 157 strikeouts this season. Gallen is 7-6 with a 3.94 ERA and 114 strikeouts in his career against the San Francisco Giants.

San Francisco Giants @ Arizona Diamondbacks Betting Trends: September 15, 2025

• Probable Starting Pitcher: Zac Gallen      Record this season: 11-14      ERA: 4.84
• Home Record: 4-7
• Last 5 against Giants: 3-2

Why the Arizona Diamondbacks will win

• The Diamondbacks have won five of their last six home games against National League opponents.
• The Giants have lost 11 of their last 13 games against National League opponents following a home loss.
• The Diamondbacks have covered the run line in each of their last six night games following a win.
• The Giants have failed to cover the run line in four of their last five games as underdogs against NL West opponents.
• The Giants have trailed after 5 innings in each of their last three games as road underdogs against NL West opponents.

• Probable Starting Pitcher: Kai-Wei Teng      Record this season: 2-4      ERA: 7.54
• Road Record: 1-3
• Last 5 against Diamondbacks: 0-0

Why the San Francisco Giants will win

• The Diamondbacks have lost four of their last five games as favorites following a road win.
• The underdogs have won each of the Diamondbacks’ last three games at Chase Field.
• The Diamondbacks have failed to cover the run line in nine of their last 10 games as favorites after playing the previous day.
• The Giants have covered the run line in eight of their last nine road games.

Total Runs Facts

• Each of the Giants’ last four games as underdogs against the Diamondbacks have gone OVER the total runs line.
• Six of the Diamondbacks’ last seven games as favorites against the Giants have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last eight home games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Giants’ last five games.

Arizona Diamondbacks Player Prop Facts

• Zac Gallen has recorded five or more strikeouts in each of his last nine appearances with the Diamondbacks as favorites against NL West opponents.
• Corbin Carroll has recorded a Double in three of the Diamondbacks’ last four games against NL opponents at Chase Field.
• Zac Gallen has recorded a win in each of his last four appearances against the Giants at Chase Field.
• Corbin Carroll has hit at least one home run in two of his last three appearances with the Diamondbacks as favorites against the Giants.
• Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last 14 games as home favorites.
• Corbin Carroll ranks 8th amongst qualified players for Slugging Percentage (.542) this season.

San Francisco Giants Player Prop Facts

• Patrick Bailey has hit a home run in three of the Giants’ last four night games.
• Jung Hoo Lee has recorded at least one hit in each of his last eight road appearances against NL West opponents.

Matchup/League Facts

• The Diamondbacks rank 4th in the league for slugging percentage this season (.434).
• The Diamondbacks are one of only four teams in the league to rank top 10 in both home runs and batting average this season.
• The Giants rank 26th in the league for hits this season (1177).
• The Giants rank T26th in the league for doubles this season (222).

San Francisco Giants vs Arizona Diamondbacks Prediction

The Giants are arguably the better team playing the better ball, but I can’t get behind Teng, who has allowed 26 hits and 19 earned runs in his last 22.2 innings. In 16 road innings, Teng has a 7.31 ERA and .288 allowed batting average. No, thanks. Gallen is having a down year, but we know what he’s capable of when he’s right, as he’s somebody who has earned CY Young votes in his career. Gallen has also allowed just 11 hits and 5 runs in his last 18.2 innings. At home and a chance to gain ground in the NL wild card, this should be a win for the Diamondbacks with their ace on the bump.