San Diego Padres vs St. Louis Cardinals Prediction 07/27/2025 Picks

The San Diego Padres and St. Louis Cardinals meet Sunday in MLB action at Busch Stadium. Here’s a San Diego Padres vs St. Louis Cardinals Prediction. This article will include a San Diego Padres vs St. Louis Cardinals Pick.

San Diego Padres Betting Preview

The San Diego Padres are 56-49 on the year and play the Mets, Cardinals, and Diamondbacks next. The San Diego Padres are batting .247 on the season, have a .315 OBP, and a .376 slugging percentage. The San Diego Padres pitching staff has a 3.60 ERA and a 1.23 WHIP. Manny Machado leads the San Diego Padres with 118 hits and 63 RBI, while Luis Arraez and Fernando Tatis Jr. have combined for 219 hits and 82 RBI. 

Stephen Kolek gets the ball for the San Diego Padres, and he is 3-5 with a 4.28 ERA and 54 strikeouts this season. This will be Kolek’s second career game against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 54-52 on the year and play the Marlins, Padres, and Dodgers next. The St. Louis Cardinals are batting .252 on the season, have a .321 OBP, and a .392 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.17 ERA and a 1.29 WHIP. Brendan Donovan leads the St. Louis Cardinals with 110 hits and 42 RBI, while Willson Contreras and Masyn Winn have combined for 193 hits and 97 RBI.

Michael McGreevy gets the ball for the St. Louis Cardinals, and he is 2-1 with a 3.49 ERA and 17 strikeouts this season. This will be McGreevy’s first career game against the San Diego Padres.

Why the St. Louis Cardinals will win

• The Cardinals have won nine of their last 10 games against NL West opponents following a home loss.
• The Padres have lost eight of their last nine road games following a win.
• The Cardinals have covered the run line in each of their last six games as favorites against NL West opponents following a home loss.
• The Padres have failed to cover the run line in four of their last five games at Busch Stadium.
• The Cardinals have led after 3 innings in three of their last four games against the Padres at Busch Stadium.
• The Padres have trailed after 5 innings in eight of their last 10 day games at Busch Stadium against NL Central opponents.

Why the San Diego Padres will win

• The Padres have won seven of their last eight day games against NL Central opponents.
• The Cardinals have lost three of their last four games as favorites against National League opponents.
• The Padres have covered the run line each of their last seven day games against teams that held a winning record.
• The Cardinals have failed to cover the run line in each of their last four day games against NL West opponents.

St. Louis Cardinals Player Prop Facts

• Willson Contreras has recorded at least one hit in 15 of his last 17 appearances against the Padres after playing the previous day.
• Lars Nootbaar has hit a home run in each of his last two appearances at Busch Stadium against NL opponents that held a winning record.
• Willson Contreras has recorded a Double in five of the Cardinals’ last six games.

San Diego Padres Player Prop Facts

• Manny Machado has hit a home run in four of the Padres’ last eight games as road underdogs against NL Central opponents.
• Xander Bogaerts has recorded a Double in three of the Padres’ last four games as road underdogs against NL opponents.
• Jose Iglesias has recorded at least one hit in 15 of his last 16 appearances in day games against NL Central teams that held a winning record.
• Luis Arraez ranks T7th in the league in Hits (115) this season.

San Diego Padres vs St. Louis Cardinals Prediction

I’m not running to the window to back either the Padres or Cardinals, two teams that have been a mess over the last week. Instead, I’m looking at the over. Kolek has allowed 17 hits and nine runs in his last 11 innings. The Padres have lost seven straight games Kolek has pitched. McGreevy has allowed 25 hits and 11 earned runs in his last 22.2 innings. In 16.1 home innings, McGreevy has a 4.96 ERA and a .250 allowed batting average. I’ll just take the over if forced to pick this contest.