San Diego Padres vs San Francisco Giants Prediction 8/13/2025 Today’s MLB Picks

The San Diego Padres and the San Francisco Giants meet Wednesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. San Francisco Giants prediction.

Starting Pitching Matchup

The San Diego Padres will send out Nick Pivetta for the start here and Pivetta is 11-4 with a 2.94 ERA and 139 strikeouts this season. In his career, Pivetta is 2-1 with a 4.87 ERA and 24 strikeouts. San Francisco will trot out Kai-Wei Teng for the start here and Teng is 1-1 with a 5.40 ERA and 8 strikeouts this season. This will be Teng’s first career start against the Padres.

San Diego Padres Recap

The San Diego Padres come into this game looking to add on to their 5-1 win over the San Francisco Giants last time out to sit at 68-52 on the year. After this series, the Padres will welcome the Los Angeles Dodgers to town for an interleague series.

Padres Win 4 Straight and 7 Of Last 9

Manny Machado has 137 hits including a team-high 29 doubles, 20 home runs, 72 RBIs and 11 stolen bases while Fernando Tatis Jr. has 118 hits with 17 home runs and 46 RBIs along with 24 stolen bases of his own this season. Luis Arraez has added 135 hits with 23 doubles, 4 triples, 6 home runs and 44 RBIs while Jackson Merrill’s added 88 hits with 9 home runs and 51 RBIs as well. Xander Bogaerts also has 26 doubles and 19 stolen bases as well this season. Gavin Sheets also has 16 doubles, 15 home runs and 54 RBIs as well this season.

Why the San Diego Padres will win

• The Giants have lost each of their last 12 home games after playing the previous day.
• The Padres have won each of their last six games after playing the previous day.
• The Giants have failed to cover the run line in each of their last 10 home games after playing the previous day.
• The Padres have covered the run line in nine of their last 10 day games against National League opponents.

San Diego Padres Player Prop Facts

• Xander Bogaerts has hit a home run in each of the Padres’ last two games as road favorites.
• Nick Pivetta has recorded seven or more strikeouts in four of his last five appearances against NL opponents that held a losing record.
• Jake Cronenworth has recorded at least one hit in each of the Padres’ last eight road games.
• Nick Pivetta has recorded a win in four of his last five appearances in day games.
• Jackson Merrill has recorded at least one Double in three of the Padres’ last four games at Oracle Park against opponents that held a losing record.
• Manny Machado ranks 2nd in the league in Hits (137) this season.

San Francisco Giants Recap

The San Francisco Giants will be looking to rebound from their 5-1 loss at the hands of the Padres on Tuesday to sit at 59-61 this season. After this series, the Rays will pay a visit to Oracle Park to duke it out with the Rays.

Giants Drop 4^th In a Row

Jung Hoo Lee has 110 hits including a team-high 27 doubles along with 9 triples, 6 home runs and 46 RBIs with 8 stolen bases while Heliot Ramos has 120 hits with 20 doubles, 14 home runs and 51 RBIs. Wilmer Flores also 12 home runs and 59 RBIs while Tyler Fitzgerald has a team-high 9 stolen bases as well on the year. Matt Chapman also has 79 hits with 16 home runs and 44 RBIs along with 15 doubles and Willy Adames has 100 hits with 18 doubles, 18 home runs and 61 RBIs of his own this season.

Why the San Francisco Giants will win

• The underdogs have won seven of the Giants’ last eight games at Oracle Park.
• The Padres have lost five of their last six games as road favorites against National League opponents following a win.
• The Padres have failed to cover the run line in each of their last eight games as favorites following a road win.
• The underdogs have covered the run line in each of the Padres’ last seven games at Oracle Park.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in three of the Giants’ last five games against NL opponents.
• Dominic Smith has recorded at least one hit in each of his last 15 appearances.
• Jung Hoo Lee has recorded a Double in each of the Giants’ last three games as underdogs against NL opponents.
• Rafael Devers ranks 10th amongst qualified players for On Base Percentage (.379) this season.

Total Runs Facts

• Thirteen of the last 15 games between the Padres and Giants at Oracle Park have gone UNDER the total runs line.
• Six of the Padres’ last seven road games against NL West opponents have gone UNDER the total runs line.

San Diego Padres vs. San Francisco Giants Prediction

I’m on the Padres here. I just like what I’ve seen from San Diego in certain games, and I think that Nick Pivetta gives the Padres a clear and decisive edge in starting pitching and it was San Diego that went out and incredibly beefed up their lineup and starting rotation. Give me San Diego here.