San Diego Padres vs Los Angeles Dodgers Prediction 9/23/2026 Today’s MLB Picks

The San Diego Padres and the Los Angeles Dodgers meet Wednesday in MLB action from Dodger Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. Los Angeles Dodgers prediction.

Starting Pitching Matchup

The San Diego Padres come into this game looking to Robbie Ray in the opener and Robbie Ray is 13-8 with a 3.60 ERA and 138 strikeouts this season. Yoshinobu Yamamoto will start here for the Dodgers and is 14-8 with a 2.51 ERA and 178 strikeouts this season. 

San Diego Padres Recap

The San Diego Padres come into this game looking to bounce back from a 7-0 loss at the hands of the Dodgers on Tuesday to sit at 87-70 this season. After this series, the Padres will head home for a game against the Arizona Diamondbacks.

Padres Have Five-Game Win Streak Snapped

Fernando Tatis Jr. leads the Padres with a team-high 174 hits while adding 30 doubles, 3 triples, 25 home runs, and 81 RBIs so far this season. Jackson Merrill leads San Diego with a team-high 86 RBIs alongside 152 hits, 25 doubles, 5 triples, and 26 home runs, while Manny Machado paces the team with 28 home runs along with 124 hits, 22 doubles, and 84 RBIs on the year. Xander Bogaerts has contributed 117 hits with 18 doubles, a triple, 12 home runs, and 56 RBIs, while Gavin Sheets has chipped in 75 hits with 15 doubles, 16 home runs, and 46 RBIs for the Padres up to this point in the season.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to add on to their win over the Padres to improve to 97-60 this season. After this series, the Dodgers will head on the road for a series against the San Francisco Giants.

Dodgers Win 5 Straight

Freddie Freeman leads the Dodgers with a team-high 165 hits while adding 32 doubles, a triple, 16 home runs, and 70 RBIs so far this season. Shohei Ohtani paces Los Angeles in power, leading the team with 30 home runs and tying for the team high with 80 RBIs alongside 139 hits, 25 doubles, and 4 triples. Andy Pages has tied Ohtani for the team lead in RBIs with 80 while logging 134 hits, 25 doubles, 2 triples, and 21 home runs. Kyle Tucker has contributed 122 hits with 23 doubles, 4 triples, 17 home runs, and 70 RBIs, while Max Muncy has added 121 hits with 26 doubles, a triple, 29 home runs, and 76 RBIs on the year. Teoscar Hernández has chipped in 113 hits with 17 doubles, 2 triples, 15 home runs, and 63 RBIs for the Dodgers up to this point in the season.

San Diego Padres @ Los Angeles Dodgers Betting Trends: September 23, 2026

• Probable Starting Pitcher: Yoshinobu Yamamoto      Record this season: 14-8      ERA: 2.51
• Home Record: 6-5
• Last 5 against Padres: 3-2

Why the Los Angeles Dodgers will win

• The Dodgers have won each of their last 11 home games.
• The Padres have lost seven of their last eight games at UNIQLO Field at Dodger Stadium.
• The Dodgers have covered the run line in seven of their last eight games.
• The Padres have failed to cover the run line each of their last three games against teams that held a winning record.
• The Padres have trailed after 3 innings in six of their last seven games as road underdogs.
• The Dodgers have led after 5 innings in each of their last six home games against NL West opponents that held a winning record.

• Probable Starting Pitcher: Robbie Ray      Record this season: 13-8      ERA: 3.60
• Road Record: 7-5
• Last 5 against Dodgers: 1-3

Why the San Diego Padres will win

• The Padres have won each of their last nine night games following a road loss.
• The Dodgers have lost five of their last six games against teams that held a winning record.
• The Padres have covered the run line in each of their last nine games as underdogs following a loss.
• The Dodgers have failed to cover the run line in four of their last five games against NL West opponents that held a winning record.
• The Dodgers have lost the first inning in three of their last four games against opponents that held a winning record.
• The Padres have led after 5 innings in eight of their last nine games against NL West opponents.

Total Runs Facts

• Each of the Padres’ last six night games after playing the previous day have gone OVER the total runs line.
• Each of the last four games between the Padres and Dodgers have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in nine of the Padres’ last 10 road games.
• There has been at least one run scored in the first inning in four of the Dodgers’ last five games.

Los Angeles Dodgers Player Prop Facts

• Will Smith has hit a home run in each of the Dodgers’ last three night games.
• Yoshinobu Yamamoto has recorded a win in three of his last four appearances against the Padres.
• Yoshinobu Yamamoto has recorded seven or more strikeouts in each of his last six appearances.
• Teoscar Hernandez has recorded at least one hit in each of the Dodgers’ last 13 home games.
• Yoshinobu Yamamoto ranks 5th amongst qualified players for Earned Run Average (2.51) this season.

San Diego Padres Player Prop Facts

• Fernando Tatis Jr. has hit a home run in two of the Padres’ last three games.
• Robbie Ray has recorded a win in each of his last seven road appearances against NL opponents.
• Samad Taylor has recorded at least one hit in each of his last eight appearances after playing the previous day.
• Robbie Ray has recorded four or more strikeouts in each of his last 10 road appearances.
• Fernando Tatis Jr. ranks T4th in the league in Hits (174) this season.

Matchup/League Facts

• The Dodgers rank 1st in the league for opponent batting average this season (.219).
• The Dodgers rank 1st in the league for hits allowed this season (1128).
• The Padres rank 5th in the league for steals this season (157).
• The Padres rank 24th in the league for doubles this season (228).

San Diego Padres vs. Los Angeles Dodgers Prediction

I’m on the Dodgers in this one. Yamamoto for me is just the far better option and Ray at times has had some major issues against the Dodgers. Los Angeles is gaining ground on the Brewers for the best record in the National League and home field in the playoffs and I think the Dodgers get it done.

Chris Ruffolo's Pick: LA Dodgers -225