Pittsburgh Pirates vs Milwaukee Brewers Prediction 4/25/2026 Today’s MLB Picks

In this article, we will formulate a Pirates vs Brewers Prediction for this MLB matchup on Saturday, April 25th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 13-12 record this season and are sitting in the fifth place of the NL Central. They have a 7-6 home record and are coming off a 0-6 home loss against the Pirates. Their previous three games were a 4-5 loss, a 2-5 loss and a 12-4 win on the road against the Tigers.

The Brewers have a .233 batting average this season, .333 OBP and .354 Slugging percentage. Milwaukee’s pitching staff has a 3.98 ERA and 1.33 WHIP. William Contreras is the team’s best hitter with a .278 batting average. Brice Turang leads the team in RBI with 18, and Gary Sanchez adds a team‑high 5 home runs.

Jacob Misiorowski (R) is the projected starting pitcher for the Brewers, and he has a 1-2 record, 3.04 ERA and 1.09 WHIP.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 15-11 record this season and are sitting in the third place of the NL Central. They have a 7-6 away record and are coming off a 6-0 road win against the Brewers. Their previous three games were a 1-6 loss, an 8-4 win and a 1-5 loss on the road against the Rangers.

The Pirates have a .246 batting average this season, .330 OBP and .386 Slugging percentage. Pittsburgh’s pitching staff has a 3.32 ERA and 1.25 WHIP. Ryan O’Hearn is the team’s best hitter with a .333 batting average. Oneil Cruz leads the team in RBI with 24, adding a team‑high 8 home runs.

Mitch Keller (R) is the projected starting pitcher for the Pirates, and he has a 2-1 record, 2.79 ERA and 1.10 WHIP.

Pittsburgh Pirates @ Milwaukee Brewers Betting Trends: April 25, 2026

• Probable Starting Pitcher: Jacob Misiorowski      Record this season: 1-2      ERA: 3.04
• Home Record: 1-0
• Last 5 against Pirates: 2-0

Why the Milwaukee Brewers will win

• The Pirates have lost each of their last nine night games at American Family Field following a road win.
• The Brewers have won 12 of their last 13 night games against the Pirates at American Family Field following a home loss.
• The Brewers have covered the run line in each of their last seven games as favorites against the Pirates.
• The Pirates have failed to cover the run line in each of their last five games following a win.
• The Pirates have trailed after 3 innings in five of their last six games at American Family Field.
• The Brewers have led after 5 innings in each of their last four games as home favorites against NL Central opponents.

• Probable Starting Pitcher: Mitch Keller      Record this season: 2-1      ERA: 2.79
• Road Record: 0-0
• Last 5 against Brewers: 1-3

Why the Pittsburgh Pirates will win

• The Brewers have lost each of their last seven games against National League opponents following a loss.
• The underdogs have won five of the Brewers’ last seven games at American Family Field.
• The Brewers have failed to cover the run line in 12 of their last 13 home games against National League opponents after playing the previous day.
• The Pirates have covered the run line in each of their last six games against NL Central opponents.
• The Pirates have led after 3 innings in six of their last seven games against opponents that held a winning record.
• The Pirates have led after 5 innings in each of their last four road games against opponents that held a winning record.
• The Pirates have won the first inning in three of their last four games as underdogs.

Total Runs Facts

• Each of the Pirates’ last four night games as underdogs have gone UNDER the total runs line.
• Five of the Brewers’ last six night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Pirates’ last eight Saturday games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last four games as favorites.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has recorded at least one hit in each of his last 13 appearances with the Brewers as favorites against the Pirates.
• Andrew Vaughn has hit a home run in each of his last two home appearances against NL Central opponents.
• Jacob Misiorowski ranks 5th in the league for total Strikeouts (42) this season.

Pittsburgh Pirates Player Prop Facts

• Marcell Ozuna has hit a home run in three of his last four appearances with his team as a road underdog against the Brewers.
• Mitch Keller has recorded five or more strikeouts in each of his six previous road appearances against the Brewers.
• Bryan Reynolds has recorded at least one hit in each of the Pirates’ last eight games as road underdogs against the Brewers.
• Oneil Cruz ranks T3rd in the league in Steals (10) this season.

Matchup/League Facts

• The Brewers rank 1st in the league for steals this season (35).
• The Brewers rank 28th in the league for hits this season (193).
• The Pirates rank 3rd in the league for ERA this season (3.32).
• The Pirates rank 3rd in the league for home runs allowed this season (19).

Pirates vs Brewers Prediction

The Brewers are 8-1 in their last 9 meetings against the Pirates and are 6-1 in their last 7 meetings in Milwaukee.

In this Pirates vs Brewers Prediction, the Brewers are coming as -135 home favorites. The Pirates won yesterday with Skenes on the mound and the Brewers have now lost three straight. Both pitchers have been very good this season with a combined 5.83 ERA and Keller’s only road start was a shutout and Misiorowski has been better at home. Yesterday’s game had 6 total runs and I don’t expect the script to flip today. Take the under 8.

Nikos Lagouretos's Pick: Under 8