Pittsburgh Pirates vs Chicago White Sox Prediction 07/19/2025 Picks

The Chicago White Sox and the Pittsburgh Pirates meet Saturday in MLB action from PNC Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Pittsburgh Pirates prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Adrian Houser for the start here, and Houser is 5-2 with a 1.56 ERA and 39 strikeouts this season. Mike Burrows will get the start in this one for Pittsburgh and is 1-3 with a 4.83 ERA and 42 strikeouts this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to build on their 10-1 win over the Pirates from Friday’s matchup to sit at 33-65 on the year. After this series, the White Sox will head on the road again for a series against the Tampa Bay Rays.

White Sox Looking To Build Some Momentum

Lenyn Sosa has 77 hits, including 14 doubles and 31 RBIs. Andrew Benintendi has 56 hits, including 10 doubles, 11 home runs, 35 RBIs, and a .233 batting average, while Miguel Vargas has 74 hits, 22 doubles, 10 home runs, and 35 RBIs. Brooks Baldwin has also added 20 RBIs, while Luis Robert Jr. has a team-high 22 stolen bases along with 35 RBIs so far this season. Chase Meidroth has added 63 hits with 11 stolen bases as well as 7 doubles this season.

Why the Chicago White Sox will win

The Pirates have lost each of their last seven night games against American League opponents.
The White Sox have won seven of their last eight night games against teams that held a losing record.
The Pirates have failed to cover the run line in each of their last eight home games against AL Central opponents.
The road team has covered the run line in each of the last six games between the White Sox and Pirates.

Chicago White Sox Player Prop Facts

Luis Robert has hit a home run in each of his last two appearances with the White Sox against NL opponents.
Adrian Houser has recorded four or more strikeouts in each of his last four appearances in night games against NL Central teams that held a losing record.
Mike Tauchman has recorded at least one hit in each of his last 10 road appearances against opponents that held a losing record.
Michael A. Taylor has recorded a Double in each of his last three appearances with the White Sox as underdogs against NL opponents.
Adrian Houser has recorded a win in each of his last three appearances.
Luis Robert ranks 10th in the league in Steals (23) this season.

Pittsburgh Pirates Recap

The Pittsburgh Pirates come into this game looking to bounce back from their loss at the hands of the White Sox to sit at 39-59 this season. After this series, the Pirates will take on the Detroit Tigers at home.

Pirates Drop 9 Of Their Last 10 Games

Bryan Reynolds has 80 hits with 17 doubles, 10 home runs, and 46 RBIs while also posting 106 strikeouts so far this season. Oneil Cruz has posted a team-high 16 home runs and 37 RBIs with 29 stolen bases while Isiah Kiner-Falefa has 76 hits with 11 doubles and 12 stolen bases. Cruz also has a team-high 116 strikeouts as well this season. Tommy Pham has 8 doubles and Andrew McCutchen has 77 hits with 14 doubles and KeBryan Hayes has 78 hits with 31 RBIs and 10 stolen bases.

Why the Pittsburgh Pirates will win

The Pirates have won each of their last six home games after playing the previous day.
The White Sox have lost seven of their last eight games against NL Central opponents.
The Pirates have covered the run line in six of their last seven night games following a loss.
The White Sox have failed to cover the run line in nine of their last 11 games following a win.

Pittsburgh Pirates Player Prop Facts

Tommy Pham has hit a home run in four of his last 10 appearances in night games against AL teams that held a losing record.
Andrew McCutchen has recorded a Double in each of his last four appearances against the White Sox after playing the previous day.
Bryan Reynolds has recorded at least one hit in each of the Pirates’ last 14 home games against AL Central opponents.
Oneil Cruz ranks 2nd in the league in Steals (30) this season.

Total Runs Facts

Five of the Pirates’ last six night games after playing the previous day have gone UNDER the total runs line.
Four of the White Sox’s last five games against NL Central opponents have gone OVER the total runs line.

Chicago White Sox vs. Pittsburgh Pirates Prediction

I’m on the White Sox in this one. I’m done waiting for the Pirates to right the ship offensively and the White Sox have been playing pretty well behind Adrian Houser, who has surprisingly taken on the role of staff ace for the White Sox up to this point in the year with a surprising start to his campaign. The Pirates just continue to be hit or miss and while Mike Burrows has been a solid option for Pittsburgh out of the gate, I just don’t believe that the Pirates can do enough against Houser to back him here and I think that the White Sox get the job done when all is said and done. Give me the White Sox.