Pirates vs Orioles Prediction 9/10/2025 Today’s MLB Picks

In this article we will formulate a Pirates vs Orioles prediction for this MLB game on Wednesday, September 10th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 64-81 this season after they lost game one by a score of 3-2 to start this series. Pittsburgh led 1-0 in the first inning, but they needed a run to tie the game in the ninth, before losing in the 11th. The Pirates recorded five hits in the game and they were led by Pham and McCutchen, who both had one RBI in the loss. Pittsburgh started Burrows, who allowed two hits and one earned run over 4.0 innings, while Moreta picked up the loss. 

Prior to this series, the Pirates lost all three against the Brewers, but did sweep the Dodgers in three games before that. Pittsburgh has lost four games in a row and they are last in the NL Central standings. The Pittsburgh pitching staff has a 3.89 ERA with a 1.23 WHIP and a .237 opponent batting average, while their offense has scored 524 runs with a .232 batting average and a .306 on base percentage this season. Oneil Cruz has led Pittsburgh with 19 home runs and 56 RBIs, while Bryan Reynolds has added 15 home runs and 70 RBIs this year. The projected starting pitcher for Pittsburgh is Paul Skenes, who is 10-9 with a 1.98 ERA and a 0.94 WHIP over 173.0 innings pitched this season. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 67-77 this year after they won game one in this series by a score of 3-2 in extra innings. Baltimore blew a 2-1 lead in the ninth, but held Pittsburgh to zero runs in the 10th and 11th for the victory. The Orioles recorded six hits in the game and they were led by Basallo, Mountcastle, and Jackson, who all had one RBI in the win. Baltimore started Bradish, who allowed four hits and one earned run over 7.0 innings, while Enns picked up the save. 

Prior to this series, the Orioles won two out of three against the Dodgers and all three against the Padres. Baltimore has won six of their last seven games and they are last in the AL East standings. The Baltimore pitching staff has a 4.63 ERA with a 1.37 WHIP and a .261 opponent batting average, while their offense has scored 623 runs with a .240 batting average and a .307 on base percentage this season. Jackson Holliday has led Baltimore with 17 home runs and 53 RBIs, while Gunnar Henderson has added 16 home runs and 61 RBIs this year. The projected starting pitcher for Baltimore is Tyler Wells, who is 1-0 with a 3.60 ERA and a 1.00 WHIP over 5.0 innings pitched this year. 

Why the Orioles will beat the Pirates

The Orioles have won five of their last six games as underdogs against National League opponents.
The Pirates have lost four of their last five games as road favorites after playing the previous day.
The Orioles have covered the run line in eight of their last nine night games following a win.
The Pirates have failed to cover the run line in four of their last five night games against AL East opponents that held a losing record.

Why the Pirates will beat the Orioles 

The Orioles have lost seven of their last eight home games against NL Central opponents following a win.
The Pirates have won each of their last four night games following a road loss.
The Orioles have failed to cover the run line each of their last eight games at Oriole Park at Camden Yards against NL Central opponents that held a losing record.
The Pirates have covered the run line in each of their last nine Wednesday games against American League opponents.
The Pirates have led after 3 innings in each of their last three games as road favorites.
The Pirates have led after 5 innings in nine of their last 11 games as favorites.
The Orioles have lost the first inning in three of their last four games against National League opponents that held a losing record.

Total Runs Facts

Each of the Orioles’ last seven games as home underdogs have gone UNDER the total runs line.
Six of the Pirates’ last seven road games against AL East opponents have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Pirates’ last 11 games as favorites against AL East opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Orioles’ last five games as home underdogs against NL Central opponents.

Baltimore Orioles Player Prop Facts

Adley Rutschman has recorded a Double in each of his last three appearances against NL Central opponents.
Gary Sanchez has recorded at least one hit in each of his last seven home appearances against NL Central opponents that held a losing record.
Tyler O’Neill has hit a home run in each of his last three home appearances with the Orioles against NL opponents.

Pittsburgh Pirates Player Prop Facts

Tommy Pham has hit a home run in each of the Pirates’ last two games against opponents that held a losing record.
Tommy Pham has recorded at least one hit in each of his last nine appearances with the Pirates as favorites.

Pirates vs Orioles Prediction 

Both of these teams come into this matchup last in their division, but they played a very entertaining game one on Tuesday night. The Orioles are 34-38 at home this season, while the Pirates are 22-48 on the road. Pittsburgh is starting Skenes, who has allowed two earned runs or fewer in four straight starts. Baltimore is going with Wells, who allowed two earned runs and five hits over 5.0 innings against San Diego in his first start of the year. We know Skenes is one of the top pitchers in the game, but Wells also has a ton of potential. Take the under here.