Phillies vs Cubs Prediction 4/21/2026 Today’s MLB Picks

In this article we will formulate a Phillies vs Cubs prediction for this MLB game on Tuesday, April 21st at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 8-14 this year after they lost game one in the series by a score of 5-1 last night. Philadelphia allowed four runs in the second inning and never had a chance in the loss. The Phillies recorded six hits in the game and they were led by Crawford, who went 1-2 with one RBI. Nola allowed six hits and five earned runs over 4.1 innings for the loss, while Shugart allowed zero earned runs over two relief innings. Prior to this series, Philadelphia lost all three against the Braves and two out of three against the Cubs. 

This season, Philadelphia has a 4.87 ERA with a 1.42 WHIP and a .275 opponent batting average, while they have scored 76 runs with a .220 batting average and a .301 on base percentage. Kyle Schwarber has led the Phillies with seven home runs and 14 RBIs, while Bryce Harper has added four home runs and 11 RBIs. The projected starting pitcher for Philadelphia is Jesus Luzardo, who is 1-3 with a 7.94 ERA and a 1.46 WHIP over 22.2 innings pitched this year. 

Chicago Cubs Betting Preview

The Chicago Cubs are 13-9 this season after they won game one by a score of 5-1 on Monday night. Chicago scored the first five runs in the game and they cruised to the easy victory. The Cubs recorded eight hits and they committed one error, while they were led by Swanson, who went 1-4 with one home run and three RBIs in the game. Rea allowed six hits and one earned run over 6.2 innings for the win, while Martin pitched a scoreless ninth. Prior to this series, Chicago swept the Mets in three games and won two out of three against the Phillies. 

This season, Chicago has a 3.47 ERA with a 1.16 WHIP and a .225 opponent batting average, while they have scored 117 runs with a .251 batting average and a .342 on base percentage. Nico Hoerner has led the Cubs with three home runs and 21 RBIs, while Dansby Swanson has added five home runs and 15 RBIs. The projected starting pitcher for Chicago is Shota Imanaga, who is 1-1 with a 2.45 ERA and a 0.77 WHIP over 22.0 innings pitched this season. 

Why the Chicago Cubs will win

• The Cubs have won each of their last seven games at Wrigley Field against National League opponents that held a losing record.
• The Phillies have lost each of their last six games against National League opponents.
• The Phillies have failed to cover the run line each of their last 10 games against National League opponents that held a winning record.
• The Cubs have covered the run line in six of their last seven home games against National League opponents that held a losing record.
• The Cubs have led after 3 innings in four of their last five night games against National League opponents that held a losing record.
• The Cubs have led after 5 innings in 13 of their last 16 night games at Wrigley Field against National League opponents.

Why the Philadelphia Phillies will win

• The Phillies have won five of their last six games as road underdogs against National League opponents following a loss.
• The Cubs have lost three of their last four night games against NL East opponents following a home win.
• The Phillies have covered the run line in nine of their last 10 games as underdogs against National League opponents following a road loss.
• The Cubs have failed to cover the run line in eight of their last 10 night games against NL East opponents following a home win.

Total Runs Facts

• Each of the Phillies’ last four games as underdogs have gone UNDER the total runs line.
• Four of the Cubs’ last five home games against NL East opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Phillies’ last four night games at Wrigley Field.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the last seven games between the Phillies and Cubs at Wrigley Field.

Chicago Cubs Player Prop Facts

• Dansby Swanson has hit a home run in each of the Cubs’ last three night games against NL opponents that held a losing record.
• Shota Imanaga has recorded seven or more strikeouts in each of his last three appearances against NL opponents.
• Ian Happ has recorded at least one hit in each of the Cubs’ last 10 games as favorites against NL East opponents.
• Shota Imanaga has recorded a win in five of his last six appearances against NL East opponents that held a losing record.

Philadelphia Phillies Player Prop Facts

• Bryce Harper has hit at least one home run in four of his last five Tuesday night appearances against NL Central teams that held a winning record.
• Bryson Stott has recorded a hit in each of his last seven appearances against NL opponents.

Phillies vs Cubs Prediction 

Chicago was able to extend their winning streak with a win on Monday night and they have allowed two runs or fewer in four of their last five games. The Cubs are 8-5 at home this year, while the Phillies are 3-4 on the road. Philadelphia has scored two runs or fewer in five straight games and they are really struggling right now. The Phillies are starting Luzardo, who has allowed 5+ earned runs in three of his four starts, while Imanaga has allowed two earned runs in his last 17.0 innings. Take the Cubs to get another win here.

David Racey's Pick: Cubs ML