Jun 21, 2025; Bronx, New York, USA; New York Yankees pitcher Clarke Schmidt (36) is greeted by catcher J.C. Escarra (25) after the fourth inning against the Baltimore Orioles at Yankee Stadium. Mandatory Credit: John Jones-Imagn Images

Orioles vs Yankees Prediction 06/22/2025 Picks

Pick details

Baltimore (33-43) vs New York (44-32)

June 22, 2025 at 11:35 AM EDT

The Line: Betting Odds: New York -1.5 — Over/Under: +9.5

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In this article we will formulate an Orioles vs Yankees prediction for this MLB game on Sunday, June 22nd at Yankee Stadium in New York. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview
The Baltimore Orioles are 33-43 this year after they split the first two games in this series by scores of 5-3 and 0-9. In their game two loss, Baltimore fell behind in the first inning and they didn’t pick up their first hit until the eighth in the loss. The Orioles recorded one hit and they committed two errors in the game, while they were led by Sanchez, who had their lone hit. Baltimore started Eflin, who allowed 10 hits and six earned runs over 3.0 innings for the loss, while Kittredge and Blewett each allowed one earned run in relief. 

Prior to this series, the Orioles split four games with the Rays and won all three against the Angels. Baltimore has won six of their last nine games and they are currently last in the AL East standings. The Baltimore pitching staff has a 4.94 ERA with a 1.44 WHIP and a .271 opponent batting average, while their offense has scored 302 runs with a .239 batting average and a .305 on base percentage this season. Cedric Mullins has led Baltimore with 12 home runs and 35 RBIs, while Ryan O’Hearn has added 10 home runs and 28 RBIs this year. The projected starting pitcher for Baltimore is Dean Kremer, who is 6-7 with a 4.80 ERA and a 1.36 WHIP over 84.1 innings pitched this year. 

New York Yankees Betting Preview
The New York Yankees are 44-32 this season after they won game two by a score of 9-0 on Saturday afternoon. New York took control of this game in the early innings and they were able to coast to the easy win. The Yankees recorded 14 hits in the game and they were led by Escarra, who went 2-3 with one home run and three RBIs in the win. New York started Schmidt, who allowed zero hits and zero earned runs over 7.0 innings for the win. 

Prior to this series, the Yankees lost three out of four against the Angels and all three against the Red Sox. New York has lost seven of their last nine games and they are currently first in the AL East standings. The New York pitching staff has a 3.50 ERA with a 1.18 WHIP and a .217 opponent batting average, while the offense has scored 391 runs with a .255 batting average and a .338 on base percentage this season. Aaron Judge has led New York with 27 home runs and 61 RBIs, while Trent Grisham has added 15 home runs and 31 RBIs this year. The projected starting pitcher for New York is Will Warren, who is 4-4 with a 4.83 ERA and a 1.33 WHIP over 69.0 innings pitched this season.

Why the Orioles will beat the Yankees
The Orioles have won each of their last seven games as underdogs against AL East opponents following a road loss.
The Yankees have lost eight of their last nine games as favorites against the Orioles following a home win.
The Orioles have covered the run line in each of their last 10 games as road underdogs against AL East opponents following a road loss.
The Yankees have failed to cover the run line in each of their last seven games as favorites against the Orioles following a win.

Total Runs Facts
Each of the Yankees’ last 10 games against American League opponents have gone UNDER the total runs line.
Seven of the Orioles’ last eight road games against AL East opponents have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Yankees’ last five games as favorites against AL East opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last four day games.

New York Yankees Player Prop Facts
Aaron Judge has hit a home run in five of the Yankees’ last six games against the Orioles at Yankee Stadium.
Aaron Judge has recorded at least one RBI in six of the Yankees’ last seven games as favorites against the Orioles.
Aaron Judge has recorded at least one hit in each of the Yankees’ last 10 Sunday games against AL opponents that held a losing record.
Aaron Judge has scored at least one run in seven of his last eight home appearances against the Orioles.

Baltimore Orioles Player Prop Facts
Dean Kremer has recorded six or more strikeouts in three of his last four appearances with the Orioles as underdogs.
Dean Kremer has recorded a win in each of his last four road appearances against AL East opponents.
Ramon Laureano has scored at least one run in five of his last six appearances with the Orioles as road underdogs against AL opponents.
Colton Cowser has hit a home run in three of the Orioles’ last five road games against AL East opponents.
Adley Rutschman has recorded an RBI in each of his last three appearances in day games against AL East teams that held a winning record.
Ryan Mountcastle has recorded at least one hit in each of his last 12 appearances at Yankee Stadium.

Orioles vs Yankees Prediction 
New York was able to get a much needed win on Saturday afternoon and they will look for the series win here. The Yankees are 23-16 at home this year, while the Orioles are just 17-24 on the road. Baltimore has played better over the last two weeks and they will start Kremer, who has allowed one earned run or fewer in three of his last five starts. New York is going with Warren, who has allowed three earned runs or more in three of his last four outings. I think we could see a higher scoring game in this matchup, but I like the Orioles with the plus money. 

David Racey's Pick: Orioles ML

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