Orioles vs Brewers Prediction 5/21/25 MLB Picks

In this article, we will formulate an Orioles vs Brewers prediction for this MLB game on Wednesday, May 21st at American Family Field in Milwaukee, Wisconsin. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 15-32 this season after they lost the first two games in this series by scores of 4-5 and 2-5. In their game two loss, Baltimore cut the deficit to 3-2 in the seventh inning, but couldn’t get any closer in the loss. The Orioles recorded eight hits and they committed two errors in the game, while they were led by Urias and Holliday, who both had one RBI in the loss. Baltimore started Akin, who opened the game, while McDermott allowed four hits and three earned runs in 4.2 innings for the loss. 

Prior to this series, the Orioles lost all three against the Nationals and all three against the Twins. Baltimore has lost eight games in a row, and they are currently last in the AL East standings. The Baltimore pitching staff has a 5.53 ERA with a 1.49 WHIP and a .276 opponent batting average, while their offense has scored 175 runs with a .230 batting average and a .297 on-base percentage this season. Cedric Mullins has led Baltimore with 10 home runs and 30 RBIs, while Ryan O’Hearn has added seven home runs and 14 RBIs this year. The projected starting pitcher for Baltimore is Tomoyuki Sugano, who is 4-3 with a 3.08 ERA and a 1.03 WHIP over 52.2 innings pitched this season. 

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 24-25 this year after they won game two by a score of 5-2 on Tuesday night. Milwaukee nearly blew a 3-0 lead in the seventh inning, but they were able to add two insurance runs in the eighth inning in the win. The Brewers recorded seven hits in the game, and they were led by Frelick, who went 1-2 with one home run and two RBIs in the win. Milwaukee started Henderson, who allowed two hits and zero earned runs over 5.0 innings for the win, while Uribe picked up the save. 

Prior to this series, the Brewers lost two out of three against the Twins and two out of three against the Guardians. Milwaukee has won three games in a row, and they are currently fourth in the NL Central standings. The Milwaukee pitching staff has a 4.09 ERA with a 1.32 WHIP and a .239 opponent batting average, while the offense has scored 208 runs with a .230 batting average and a .309 on-base percentage this season. Jackson Chourio has led Milwaukee with seven home runs and 25 RBIs, while Christian Yelich has added seven home runs and 26 RBIs this year. The projected starting pitcher for Milwaukee is Chad Patrick, who is 2-4 with a 3.35 ERA and a 1.28 WHIP over 48.1 innings pitched this year. 

Why the Orioles will beat the Brewers 

• The Brewers have lost seven of their last nine day games following a win.
• The road team has won seven of the Orioles’ last nine games.
• The Brewers have failed to cover the run line in five of their last six day games following a home win.
• The Orioles have covered the run line in six of their last eight games as underdogs against NL Central opponents following a loss.

Total Runs Facts

• Five of the Orioles’ last six day games against National League opponents have gone OVER the total runs line.
• Four of the last five games between the Orioles and Brewers have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Orioles’ last nine games as underdogs against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last four games as favorites against American League opponents.

Milwaukee Brewers Player Prop Facts

• Rhys Hoskins has recorded at least one RBI in five of the Brewers’ last six games as home favorites.
• Rhys Hoskins has recorded a Double in four of the Brewers’ last five games as home favorites.
• Brice Turang has recorded at least one Single in each of his last nine appearances at American Family Field against AL opponents that held a losing record.
• Brice Turang has scored at least one run in each of the Brewers’ last six games as home favorites against AL East opponents.
• Jackson Chourio has hit at least one home run in four of the Brewers’ last 10 day games against opponents that held a losing record.
• Brice Turang has recorded at least one hit in each of his last 11 home appearances against opponents that held a losing record.

Baltimore Orioles Player Prop Facts

• Cedric Mullins has hit a home run in three of the Orioles’ last five games against NL Central opponents.
• Ramon Urias has recorded an RBI in four of his last five appearances against opponents that held a losing record.
• Ramon Urias has scored at least one run in each of his last four road appearances against NL Central opponents that held a losing record.
• Cedric Mullins has recorded at least one Single in eight of the Orioles’ last nine road games against NL opponents that held a losing record.
• Cedric Mullins has recorded at least one hit in each of the Orioles’ last nine road games against NL opponents that held a losing record.

Orioles vs Brewers Prediction 

Baltimore lost another game on Tuesday night, and their losing streak is now at eight games, as they continue to struggle this season. The Orioles are 7-17 on the road this year, while the Brewers are 15-9 at home. Milwaukee has won three games in a row, and they have scored five runs in each game. The Brewers are starting Patrick, who has allowed three earned runs in three of his last four starts. The Orioles are starting Sugano, who has allowed two earned runs or fewer in three of his last four. This Baltimore lineup has been terrible, but I think Sugano gives them a great chance to win. Take the Orioles here.