Oakland Athletics vs Pittsburgh Pirates Prediction 9/19/2025 Today’s MLB Picks

In this article, we will formulate an Athletics vs Pirates Prediction for this MLB game on Friday, September 19th at the PNC Park in the opening game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 65-88 record this season and are sitting on the last place of the NL Central. They have a 42-36 home record, and are 61-87 in over/under. They are coming off a 4-8 home defeat by the Cubs, and are 1-10 in their last 11 games. Under is 7-3 in their last 10 games are playing the Reds and the Braves next.

The Pirates have a .230 batting average this season, .304 OBP and .347 slugging percentage. Pittsburgh’s pitching staff has a 3.87 ERA and 1.23 WHIP. Bryan Reynolds leads the Pirates with 134 hits, and a team-high 71 RBI. He is also the team’s best hitter with a .241 batting average, while Oneil Cruz leads the team in home runs, with 19.

Mitch Keller (R) is the projected starting pitcher for the Pirates, and he has a 6-14 record, 4.13 ERA and 1.25 WHIP.

Athletics Preview

The Athletics have a 72-81 record this season and are sitting on the last place of the AL West. The Athletics have a 39-39 road record and are 75-71 in over/under. They are coming off a 11-5 home victory over the Reds, and have three straight wins. Under is 7-3 in their last 10 games and are playing the Astros and the Royals next.

The Athletics have a .255 batting average this season, .321 OBP and .435 Slugging percentage. Athletics’ pitching staff has a 4.72 ERA and 1.36 WHIP. Brent Rooker leads the Athletics with 160 hits, while Jacob Wilson is the team’s best hitter with a .320 batting average. Tyler Soderstrom adds a team-high 90 RBI, while Nick Kurtz adds a team-high 32 home runs. 

Luis Severino (R) is the projected starter for the Athletics, and he has a 6-11 record, 4.82 ERA, and 1.32 WHIP.

Athletics @ Pittsburgh Pirates Betting Trends: September 19, 2025

• Probable Starting Pitcher: Mitch Keller      Record this season: 6-14      ERA: 4.13
• Home Record: 3-9
• Last 5 against Athletics: 0-2

Why the Pittsburgh Pirates will win

• The Athletics have lost each of their last four games as road favorites against NL Central opponents.
• The Pirates have won six of their last seven games as home underdogs against AL West opponents following a loss.
• The Pirates have covered the run line in each of their last nine games as home underdogs against AL West opponents following a loss.
• The Athletics have failed to cover the run line in seven of their last eight road games against National League opponents following a win.
• The Athletics have trailed after 3 innings in three of their last four games.
• The Pirates have led after 5 innings in five of their last six home games against opponents that held a losing record.

• Probable Starting Pitcher: Luis Severino      Record this season: 6-11      ERA: 4.82
• Road Record: 5-2
• Last 5 against Pirates: 3-1

Why the Athletics will win

• The Pirates have lost each of their last 10 night games against American League opponents that held a losing record.
• The Athletics have won each of their last five games against the Pirates.
• The Athletics have covered the run line in each of their last seven games.
• The Pirates have failed to cover the run line in each of their last six home games.
• The Pirates have lost the first inning in three of their last four home games.
• The Athletics have led after 3 innings in seven of their last eight night games against opponents that held a losing record.
• The Athletics have led after 5 innings in each of their last four games against the Pirates.

Total Runs Facts

• Each of the Athletics’ last six games as favorites have gone UNDER the total runs line.
• Each of the Pirates’ last four games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Athletics’ last six games as road favorites against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last six night games between the Athletics and Pirates.

Pittsburgh Pirates Player Prop Facts

• Tommy Pham has hit a home run in three of his last four appearances against the Athletics after not playing the previous day.
• Bryan Reynolds has recorded a Double in each of the Pirates’ last four games as home underdogs against AL opponents.
• Mitch Keller has recorded five or more strikeouts in each of his last six appearances against AL West opponents.
• Oneil Cruz has recorded at least one hit in each of his last 11 appearances with the Pirates as underdogs against AL opponents.
• Oneil Cruz ranks 4th in the league in Steals (38) this season.

Athletics Player Prop Facts

• Nick Kurtz has hit a home run in three of the Athletics’ last four games against NL opponents.
• Luis Severino has recorded a win in each of his three previous appearances with his team as a favorite against the Pirates.
• Luis Severino has recorded five or more strikeouts in nine of his last 10 appearances with his team as a favorite.
• Shea Langeliers has recorded at least one hit in each of the Athletics’ last eight games as favorites against NL opponents.
• Zack Gelof has recorded a Double in three of his last four road appearances against NL opponents.
• Jacob Wilson ranks 2nd amongst qualified players for Batting Average (.320) this season.

Matchup/League Facts

• The Pirates rank 30th in the league for runs scored this season (545).
• The Pirates rank 30th in the league for home runs this season (108).
• The Athletics rank T2nd in the league for doubles this season (279).
• The Athletics rank 29th in the league for home runs allowed this season (213).

Athletics vs Pirates Prediction

The A’s have won their last 5 meetings against the Pirates, but the Pirates are 3-2 in their last 5 meetings in Pittsburgh. Under is 5-2-3 in their last 10 meetings.

In this Athletics vs Pirates Prediction, both teams are coming at a pickem price. I don’t trust either pitching in this matchup, as both have been shaky at best this season. Severino has 8 earned runs in his last two starts for the A’s, while Keller has at least two earned runs in his last four home starts. Both bullpens are terrible and both offenses are slightly better against right-handed pitching, so I like this game to go over the 8.5 total.