Sep 10, 2025; San Diego, California, USA; San Diego Padres starting pitcher Nick Pivetta (27) reacts after a strike out during the third inning against the Cincinnati Reds at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

NRFI & YRFI Best Bets 9/17/2025 Today’s MLB Picks

Pick details

Chicago (86-64) vs Pittsburgh (65-86)

September 17, 2025 at 12:35 PM EDT

The Line: Betting Odds: Pittsburgh +1.5 — Over/Under: +8

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Chicago Cubs vs Pittsburgh Pirates 12:35 PM EST

Pick: NRFI

The Chicago Cubs and Pittsburgh Pirates meet in the final game of their series, with the Cubs sitting at 86-64 and pushing toward the postseason, while the Pirates enter at 65-86 and looking to play spoiler. The pitching matchup features veteran left-hander Matthew Boyd for Chicago, who carries a 13-8 record and a 3.05 ERA, against Johan Oviedo for Pittsburgh, who has been sharp in limited work with a 2-0 record and a 2.81 ERA. While Oviedo has pitched well, the Pirates’ lack of consistent offense has been a season-long issue, and it often leaves their starters without run support. I expect Oviedo to continue his success, and this should be a good spot for Boyd as well, with how the Pirates have batted against left-handed pitching this season. 

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San Diego Padres vs New York Mets 7:10 PM EST

Pick: NRFI

The San Diego Padres and New York Mets face off at Citi Field in a matchup with postseason implications for both clubs. The Padres enter at 82-68, aiming to strengthen their playoff position, while the Mets sit at 77-73, clinging to their Wild Card hopes and needing every win down the stretch. San Diego will send Nick Pivetta to the mound, who has been excellent this season with a 13-5 record and a 2.73 ERA, while New York counters with left-hander David Peterson, who is 9-5 with a 3.77 ERA. The Mets exploded in the first inning of Tuesday’s game, but I don’t see them replicating that against a guy like Pivetta. On the other hand, we have seen the Padres struggle against left-handed pitching down the stretch, so Peterson should get us out of the 1st inning as well. 


Texas Rangers vs Houston Astros 8:10 PM EST

Pick: NRFI

The Texas Rangers and Houston Astros meet in a pivotal AL West showdown at Minute Maid Park, with both teams fighting for postseason positioning. The Astros enter at 82-69, looking to protect their division standing, while the Rangers sit at 79-72, still chasing a Wild Card spot with little room for error. Texas turns to ace Jacob deGrom, who has been excellent this season with a 12-7 record and a 2.82 ERA, while Houston counters with Cristian Javier, who has struggled to a 1-3 record and an ERA in the mid-4s but has shown flashes of dominance, especially at home. I have no doubt Degrom can get us out of the first, and Javier should get the job done as well.

Brad Francis's Pick: See Above

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