New York Yankees vs Minnesota Twins Prediction 9/16/2025 Today’s MLB Picks

The New York Yankees and the Minnesota Twins meet Tuesday in MLB action from Target Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Yankees vs. Minnesota Twins prediction.

Starting Pitching Matchup

The New York Yankees will send out Cam Schlittler for the start here and Schlittler is 3-3 with a 3.05 ERA and 63 strikeouts this season. This will be Schlittler’s second career start against the Twins. Zebby Matthews will start this one for the Twins and is 4-5 with a 5.06 ERA and 80 strikeouts this season. This will be Matthews’ second career start against the Yankees.

New York Yankees Recap

The New York Yankees come into this game looking to rebound from their series-opening 7-0 loss at the hands of the Twins on Monday to sit at 83-67 this season. After this series, the Yankees will head on the road for another division series against the Baltimore Orioles.

Yankees Drop Back-To-Back Games

Aaron Judge leads the Yankees with 163 hits including 48 home runs, 102 RBIs, 28 doubles and a .326 batting average along with 11 stolen bases. Anthony Volpe’s also had 29 doubles with 16 stolen bases, 19 home runs and 70 RBIs while Jasson Dominguez has added 17 doubles of his own. Paul Goldschmidt has 126 hits with 30 doubles and a .278 batting average while Volpe also has 140 strikeouts so far this season. Ben Rice also has 105 hits with 25 doubles, 23 home runs and 56 RBIs while Cody Bellinger has 28 homers with 93 RBIs and Austin Wells has 21 home runs and 66 RBIs with Bellinger logging 25 doubles and Wells chipping in 19 doubles. Trent Grisham also has 30 home runs and 64 RBIs and Jazz Chisholm Jr. has 29 home runs and 75 RBIs so far this season.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to add on to their win over the Yankees from Monday’s matchup to sit at 66-84 on the year. After this series, the Twins will take on the Cleveland Guardians in a division series at home.

Twins Looking To Play Spoiler

Byron Buxton has 119 hits along with 18 doubles, a team-high 31 home runs and 76 RBIs with 22 stolen bases and 7 triples while Trevor Larnach’s chipped in 119 hits with 21 doubles, 16 home runs and 58 RBIs as well this season. Brooks Lee has contributed 105 hits with 14 doubles, 14 home runs and 58 RBIs and Matt Wallner has 22 homers and 40 RBIs as well. 

New York Yankees @ Minnesota Twins Betting Trends: September 16, 2025

• Probable Starting Pitcher: Zebby Matthews      Record this season: 4-5      ERA: 5.06
• Home Record: 2-1
• Last 5 against Yankees: 0-1

Why the Minnesota Twins will win

• The underdogs have won seven of the Twins’ last eight games at Target Field.
• The Yankees have lost four of their last five games as favorites against AL Central opponents.
• The underdogs have covered the run line in each of the Twins’ last 14 games.
• The Yankees have failed to cover the run line in four of their last five games against AL Central opponents.
• The Twins have led after 5 innings in each of their last six home games against opponents that held a winning record.
• The Twins have led after 3 innings in four of their last five home games against opponents that held a winning record.

• Probable Starting Pitcher: Cam Schlittler      Record this season: 3-3      ERA: 3.05
• Road Record: 0-1
• Last 5 against Twins: 0-0

Why the New York Yankees will win

• The Twins have lost each of their last nine games following a home win.
• The Yankees have won eight of their last nine night games against teams that held a losing record.
• The Twins have failed to cover the run line in each of their last nine games following a home win.
• The Yankees have covered the run line in each of their last nine Tuesday games as road favorites against AL Central opponents.
• The Yankees have won the first inning in three of their last four games as favorites.
• The Yankees have led after 5 innings in six of their last seven games as road favorites.
• The Yankees have led after 3 innings in 10 of their last 11 games against the Twins.

Total Runs Facts

• Each of the last four games between the Yankees and Twins at Target Field have gone UNDER the total runs line.
• Each of the Yankees’ last three games as favorites have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Twins’ last eight home games against AL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Yankees’ last five games.

Minnesota Twins Player Prop Facts

• Trevor Larnach has recorded a Double in each of the Twins’ last three games as home underdogs against AL opponents.
• Trevor Larnach has recorded at least one hit in each of the Twins’ last nine home games against AL opponents.
• James Outman has hit a home run in each of his last two appearances with the Twins as underdogs.
• Byron Buxton ranks 5th amongst qualified players for Slugging Percentage (.553) this season.

New York Yankees Player Prop Facts

• Aaron Judge has hit at least one home run in three of the Yankees’ last four night games.
• Anthony Volpe has recorded at least one hit in each of his 14 previous appearances against the Twins after playing the previous day.
• Jose Caballero ranks 1st in the league in Steals (46) this season.

Matchup/League Facts

• The Twins rank T3rd in the league for walks allowed this season (431).
• The Twins rank 25th in the league for opponent batting average this season (.259).
• The Yankees rank 1st in the league for runs scored this season (774).
• The Yankees rank 1st in the league for home runs this season (254).

New York Yankees vs. Minnesota Twins Prediction

I’m on the Yankees here. I got burned with New York on Monday, but I think this is an important series for the Yankees, who can ill afford to lose any more ground in the division race with the Blue Jays continuing to find ways to win in improbable situations. The Twins got a big win over the Yankees in convincing fashion on Monday, but I just feel like the Yankees won’t stay down for long if at all in this series and I think they bounce back here. Give me New York for the revenge W.