New York Yankees vs Arizona Diamondbacks Prediction 9/19/2026 Today’s MLB Picks

The New York Yankees and the Arizona Diamondbacks meet Saturday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Yankees vs. Arizona Diamondbacks prediction.

Starting Pitching Matchup

The New York Yankees will send out Cam Schlittler for the start here and Schlittler is 14-6 with a 1.95 ERA and 228 strikeouts this season. Brandon Pfaadt will start for the Diamondbacks and is 7-3 with a 3.77 ERA and 84 strikeouts this season.

New York Yankees Recap

The New York Yankees come into this game looking to add on to their 9-2 win over the Diamondbacks last time out to sit at 89-64 this season. After this series, New York will head home for a series against the Tampa Bay Rays.

Yankees Win 8 Of Last 10

Ben Rice leads the Yankees with a team-high 144 hits, 39 home runs, and 94 RBIs while adding 22 doubles and 4 triples so far this season. Cody Bellinger has added 130 hits with 25 doubles, 3 triples, 16 home runs, and 71 RBIs, while Jazz Chisholm Jr. has chipped in 107 hits with 16 doubles, 3 triples, 19 home runs, and 55 RBIs. Jose Caballero has logged 92 hits with 13 doubles, 14 home runs, and 51 RBIs, while Trent Grisham has contributed 88 hits with 19 doubles, 2 triples, 18 home runs, and 59 RBIs for New York. Aaron Judge has also recorded 57 hits with 10 doubles, 18 home runs, and 41 RBIs on the year.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to bounce back from their loss at the hands of the Yankees on Friday to sit at 80-74 this season. After this series, the Diamondbacks will head on the road for a series against the Rockies.

Diamondbacks Lose 3 Straight & 6 Of Last 8

Gabriel Moreno leads the Diamondbacks with a team-high 136 hits and 75 RBIs while adding 32 doubles, a triple, and 15 home runs so far this season. Geraldo Perdomo has added 135 hits with 19 doubles, 6 triples, 9 home runs, and 50 RBIs, while Corbin Carroll has logged 133 hits with 31 doubles, 16 triples, 22 home runs, and 69 RBIs on the year. Ketel Marte has contributed 132 hits with 29 doubles, 3 triples, 22 home runs, and 74 RBIs, Nolan Arenado leads Arizona with a team-high 26 home runs alongside 123 hits, 23 doubles, a triple, and 74 RBIs, and Ildemaro Vargas has chipped in 111 hits with 19 doubles, 5 triples, 9 home runs, and 67 RBIs up to this point in the season.

New York Yankees @ Arizona Diamondbacks Betting Trends: September 19, 2026

• Probable Starting Pitcher: Brandon Pfaadt      Record this season: 7-3      ERA: 3.77
• Home Record: 3-2
• Last 5 against Yankees: 0-1

Why the Arizona Diamondbacks will win

• The Diamondbacks have won eight of their last nine games as underdogs following a home loss.
• The Yankees have lost each of their last five games against NL opponents following a road win.
• The underdogs have covered the run line in 11 of the Diamondbacks’ last 12 games.
• The Yankees have failed to cover the run line in each of their last four night games against NL opponents following a road win.
• The Diamondbacks have led after 3 innings in five of their last six home games against AL opponents that held a winning record.
• The Diamondbacks have led after 5 innings in eight of their last nine night games at Chase Field against AL East opponents.

• Probable Starting Pitcher: Cam Schlittler      Record this season: 14-6      ERA: 1.95
• Road Record: 8-2
• Last 5 against Diamondbacks: –

Why the New York Yankees will win

• The Yankees have won each of their last seven night games after playing the previous day.
• The Diamondbacks have lost seven of their last eight games against AL East opponents.
• The Diamondbacks have failed to cover the run line in each of their last six games.
• The Yankees have covered the run line in each of their last six games against NL West opponents.
• The Yankees have won the first inning in four of their last five games against NL opponents.
• The Diamondbacks have trailed after 3 innings in each of their last seven night games against AL opponents that held a winning record.
• The Diamondbacks have trailed after 5 innings in each of their last nine night games against opponents that held a winning record.

Total Runs Facts

• Eight of the Yankees’ last nine night games after playing the previous day have gone OVER the total runs line.
• Seven of the Diamondbacks’ last eight games as underdogs have gone UNDER the total runs line.
• There has been no run scored during the first inning in each of Brandon Pfaadt’s last six home appearances as a starter.
• There has been at least one run scored in the first inning in seven of the Yankees’ last eight games.

Arizona Diamondbacks Player Prop Facts

• Ketel Marte has hit a home run in each of his last two appearances with the Diamondbacks as underdogs against AL East opponents.
• Brandon Pfaadt has recorded a win in three of his last four home appearances against AL East opponents.
• Brandon Pfaadt has recorded five or more strikeouts in each of his last three home appearances against AL opponents that held a winning record.
• Nolan Arenado has recorded at least one hit in each of his last 16 appearances against the Yankees.
• Gabriel Moreno ranks 6th amongst qualified players for Batting Average (.304) this season.

New York Yankees Player Prop Facts

• Cam Schlittler has recorded a win in four of his last five appearances.
• Cam Schlittler has recorded seven or more strikeouts in seven of his last eight road appearances.
• Ryan McMahon has recorded at least one hit in each of his last 15 appearances with his team as a favorite against the Diamondbacks.
• Aaron Judge has hit at least one home run in four of his last five appearances with the Yankees as road favorites against NL West opponents.
• Cam Schlittler ranks 2nd amongst qualified players for Earned Run Average (1.95) this season.

Matchup/League Facts

• The Diamondbacks rank 2nd in the league for triples this season (36).
• The Diamondbacks rank 29th in the league for strikeouts this season (1080).
• The Yankees rank 1st in the league for ERA this season (3.18).
• The Yankees rank 1st in the league for runs allowed this season (563).

New York Yankees vs. Arizona Diamondbacks Prediction

I’m on the Yankees in this one. Brandon Pfaadt has been a decent option for Arizona this season, but I just think the Yankees are the better team with the more potent lineup in this spot and I look for the Yankees to kick the crap out of the Diamondbacks as they continue their push into the postseason. I’ll back New York in this one.

Chris Ruffolo's Pick: New York Yankees -165