New York Yankees vs Arizona Diamondbacks Prediction 9/18/2026 Today’s MLB Picks

In this article, we will formulate a Yankees vs Diamondbacks Prediction for this MLB matchup on Friday, September 18th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 80-73 record this season and are sitting in the 3rd place of the NL West. They have a 43-35 home record and are coming off a 3-4 home loss against the Marlins. They will face the Rockies and the Padres next.

The Arizona Diamondbacks have a .244 batting average this season, .316 OBP and .397 Slugging percentage. Arizona’s pitching staff has a 4.09 ERA and 1.28 WHIP. Gabriel Moreno is the team’s best hitter with a .307 batting average, adding a team-high 75 RBI. Nolan Arenado adds a team-high 26 home runs.

Eduardo Rodriguez (L) is the projected starting pitcher for the Diamondbacks, and he has a 15-6 record, 2.62 ERA and 1.22 WHIP.

New York Yankees Preview

The New York Yankees have a 88-64 record this season and are sitting in the 2nd place of the AL East. They have a 46-32 away record and are coming off a 4-5 road loss against the Twins. They will face the Rays and the Orioles next.

The New York Yankees have a .235 batting average this season, .312 OBP and .409 Slugging percentage. New York’s pitching staff has a 3.19 ERA and 1.16 WHIP. Cody Bellinger is the team’s best hitter with a .276 batting average. Ben Rice leads the team in RBI with 92, adding a team-high 38 home runs.

Gerrit Cole (R) is the projected starting pitcher for the Yankees, and he has a 8-9 record, 3.67 ERA and 1.13 WHIP.

New York Yankees @ Arizona Diamondbacks Betting Trends: September 18, 2026

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 15-6      ERA: 2.62
• Home Record: 8-5
• Last 5 against Yankees: 2-0

Why the Arizona Diamondbacks will win

• The Diamondbacks have won eight of their last nine games as underdogs following a home loss.
• The Yankees have lost each of their last four Friday night games as favorites against NL West opponents.
• The underdogs have covered the run line in 10 of the Diamondbacks’ last 11 games.
• The Yankees have failed to cover the run line each of their last four night games against NL opponents that held a winning record.
• The Diamondbacks have led after 3 innings in each of their last five home games against AL opponents that held a winning record.
• The Diamondbacks have led after 5 innings in each of their last eight night games at Chase Field against AL East opponents.

• Probable Starting Pitcher: Gerrit Cole      Record this season: 8-9      ERA: 3.67
• Road Record: 5-5
• Last 5 against Diamondbacks: 2-2

Why the New York Yankees will win

• The Yankees have won each of their last nine games following a loss.
• The Diamondbacks have lost each of their last four night games against AL East opponents.
• The Yankees have covered the run line in each of their last six games following an extra innings loss.
• The Diamondbacks have failed to cover the run line in each of their last five games.
• The Diamondbacks have trailed after 3 innings in each of their last six night games against AL opponents that held a winning record.
• The Yankees have won the first inning in three of their last four games against NL opponents.
• The Diamondbacks have trailed after 5 innings in each of their last eight night games against opponents that held a winning record.

Total Runs Facts

• Each of the Yankees’ last seven road games after going to extra innings have gone UNDER the total runs line.
• Seven of the Diamondbacks’ last eight games as underdogs have gone UNDER the total runs line.
• There has been no run scored during the first inning in each of the Diamondbacks’ last six night games against AL opponents.
• There has been at least one run scored in the first inning in each of the Yankees’ last four games against NL opponents.

Arizona Diamondbacks Player Prop Facts

• Gabriel Moreno has hit a home run in three of the Diamondbacks’ last four games.
• Eduardo Rodriguez has recorded a win in six of his last seven appearances with the Diamondbacks as underdogs.
• Eduardo Rodriguez has recorded six or more strikeouts in three of his last four appearances.
• Nolan Arenado has recorded at least one hit in each of his last 15 appearances against the Yankees.
• Eduardo Rodriguez ranks T3rd in the league for Wins (15) this season.

New York Yankees Player Prop Facts

• Aaron Judge has hit at least one home run in four of his last five appearances with the Yankees as road favorites against NL West opponents.
• Gerrit Cole has recorded a win in 10 of his last 12 appearances with his team as a road favorite against NL West opponents .
• Gerrit Cole has recorded six or more strikeouts in 10 of his last 11 appearances with his team as a favorite against NL West opponents.
• Ryan McMahon has recorded at least one hit in each of his last 15 appearances with his team as a favorite against the Diamondbacks.
• Ben Rice ranks T6th in the league in Home Runs (38) this season.

Matchup/League Facts

• The Diamondbacks rank T1st in the league for triples this season (36).
• The Diamondbacks rank 29th in the league for strikeouts this season (1073).
• The Yankees rank 1st in the league for ERA this season (3.19).
• The Yankees rank 1st in the league for runs allowed this season (561).

Yankees vs Diamondbacks Prediction

Both teams are tied 4-4 in their last 8 meetings and the Yankees have won two of their last three visits in Arizona.

In this Yankees vs Diamondbacks Prediction, the Yankees are coming as -125 road favorites. I like the Yankees on the road in an excellent price. Cole has not been in good form, but Rodriguez has given up 3 runs in each of his last two home starts and the Yankees have been insanely good against lefties in their last 10 games with .328 batting average and 10.1 runs per game. They have also been in better form overall with a 7-2 record in their last 9 games, while the Dbacks are 1-4 in their last 5. Take the Yankees in this one.

Nikos Lagouretos's Pick: New York Yankees ML