Minnesota Twins vs San Francisco Giants Prediction 9/23/2026 Today’s MLB Picks

The Minnesota Twins and the San Francisco Giants meet Wednesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Connor Prielipp for the start and Prielipp is 6-7 with a 4.94 ERA and 125 strikeouts this season. Cesar Perdomo will start for San Francisco and is 0-1 with a 3.72 ERA and 12 strikeouts this season.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to add on to their 3-2 win over the Giants on Tuesday to sit at 74-84 this season. After this series, the Twins will head home for a set against the Texas Rangers.

Twins Alternate Wins & Losses In 8 Straight

Entering Tuesday, Brooks Lee leads the Twins with a team-high 143 hits while adding 24 doubles, 3 triples, 24 home runs, and 82 RBIs so far this season. Josh Bell leads Minnesota with a team-high 91 RBIs alongside 142 hits, 28 doubles, a triple, and 20 home runs on the year. Luke Keaschall has contributed 141 hits with 26 doubles, a triple, 9 home runs, and 46 RBIs, while Kody Clemens leads the Twins with a team-high 26 home runs along with 121 hits, 22 doubles, 7 triples, and 76 RBIs. Byron Buxton has added 94 hits with 18 doubles, a triple, 25 home runs, and 46 RBIs, and Victor Caratini has chipped in 71 hits with 9 doubles, 7 home runs, and 44 RBIs up to this point in the season.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to bounce back from their loss at the hands of the Twins on Tuesday to slip to 65-93 this season. After this series, the Giants will take on the Los Angeles Dodgers in a series at home.

Giants Drop 4 Of Last 5

Jung Hoo Lee leads the Giants with a team-high 149 hits while adding 31 doubles, 4 triples, 10 home runs, and 57 RBIs so far this season. Rafael Devers paces San Francisco across the board in power, leading the team with 37 home runs and 98 RBIs alongside 144 hits, 36 doubles, and a triple on the year. Willy Adames has contributed 107 hits with 25 doubles, a triple, 21 home runs, and 51 RBIs while logging 139 strikeouts. Matt Chapman has logged 72 hits with 18 doubles, a triple, 7 home runs, and 42 RBIs for San Francisco up to this point in the season.

Minnesota Twins @ San Francisco Giants Betting Trends: September 23, 2026

• Probable Starting Pitcher: Cesar Perdomo      Record this season: 0-1      ERA: 3.72
• Home Record: 0-1
• Last 5 against Twins: –

Why the San Francisco Giants will win

• The Twins have lost each of their last eight road games following a win.
• The Giants have won four of their last six games as home underdogs against AL Central opponents following a loss.
• The underdogs have covered the run line in each of the last eight games between the Twins and Giants.
• The Twins have failed to cover the run line in each of their last eight games as favorites against NL opponents.
• The Giants have won the first inning in seven of their last nine home games.
• The Giants have led after 3 innings in each of their last four games against opponents that held a losing record.
• The Giants have led after 5 innings in eight of their last nine home games against opponents that held a losing record.

• Probable Starting Pitcher: Connor Prielipp      Record this season: 6-7      ERA: 4.94
• Road Record: 1-4
• Last 5 against Giants: –

Why the Minnesota Twins will win

• The Giants have lost each of their last eight day games against AL Central opponents that held a losing record.
• The Twins have won four of their last five games against the Giants.
• The Giants have failed to cover the run line each of their last eight day games against AL Central opponents that held a losing record.
• The Twins have covered the run line in each of their last seven Wednesday games against NL West opponents.
• The Twins have led after 5 innings in each of their last six Wednesday games against NL West opponents that held a losing record.
• The Twins have led after 3 innings in each of their last six Wednesday games against NL West opponents that held a losing record.

Total Runs Facts

• Each of the last four games between the Twins and Giants at Oracle Park have gone UNDER the total runs line.
• Each of the Twins’ last four games as favorites against NL opponents have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in nine of Connor Prielipp’s 10 previous road appearances as a starter.
• There has been at least one run scored in the first inning in eight of the Giants’ last nine home games.

San Francisco Giants Player Prop Facts

• Drew Gilbert has hit a home run in two of the Giants’ last three games against opponents that held a losing record.
• Drew Gilbert has recorded at least one hit in each of his last nine home appearances against opponents that held a losing record.

Minnesota Twins Player Prop Facts

• Brooks Lee has hit a home run in three of the Twins’ last four games against NL opponents.
• Connor Prielipp has recorded a win in four of his last five appearances with the Twins as favorites.
• Connor Prielipp has recorded six or more strikeouts in each of his last four appearances against NL opponents.
• Brooks Lee has recorded at least one hit in 17 of his last 18 road appearances after playing the previous day.

Matchup/League Facts

• The Giants rank 30th in the league for walks this season (443).
• The Giants rank 29th in the league for on-base percentage this season (.309).
• The Twins rank 26th in the league for runs allowed this season (783).
• The Twins rank 25th in the league for walks this season (494).

Minnesota Twins vs. San Francisco Giants Prediction

I’m on the Giants here. Minnesota’s had issues stringing wins together as of late and the Twins have also had big time struggles against lefties this season. I think Perdomo is a solid option for San Francisco’s rotation and I think San Francisco takes one here. Give me the Giants.

Chris Ruffolo's Pick: San Francisco +135