Jul 30, 2025; Cleveland, Ohio, USA; Cleveland Guardians third baseman Jose Ramirez (11) singles in the eighth inning against the Colorado Rockies at Progressive Field. Mandatory Credit: David Richard-Imagn Images

Minnesota Twins vs Cleveland Guardians Prediction 08/02/2025 Today’s MLB Picks

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Minnesota (51-58) vs Cleveland (55-54)

August 2, 2025 at 04:10 PM EDT

The Line: Betting Odds: Cleveland — Over/Under:

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The Minnesota Twins and the Cleveland Guardians meet Saturday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Minnesota Twins did not have a starting pitcher announced at the time that this article was posted. The Cleveland Guardians will start Tanner Bibee here and Bibee is 7-9 with a 4.39 ERA and 107 strikeouts this season. In his last five starts against the Twins, Bibee is 2-0 with a 1.71 ERA and 32 strikeouts.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to rebound from a 3-2 loss at the hands of the Guardians on Friday to sit at 51-58 this season. After this series, the Twins head on the road for an important division series against the Detroit Tigers.

Twins Lose 5 Of Their Last 6 Games

Byron Buxton has 92 hits along with 14 doubles, a team-high 23 home runs and 59 RBIs with 17 stolen bases and 4 triples while Trevor Larnach’s chipped in 85 hits with 15 doubles, 13 home runs and 43 RBIs as well this season. Brooks Lee has contributed 78 hits with 10 doubles, 10 home runs and 43 RBIs and Matt Wallner has 13 homers and 22 RBIs as well.

Why the Minnesota Twins will win

  • The Guardians have lost five of their last six day games at Progressive Field following an extra innings win.
  • The Twins have won five of their last six games following a road loss.
  • The road team has covered the run line in eight of the Twins’ last nine games.
  • The Guardians have failed to cover the run line in each of their last four games against American League opponents following a win.

Minnesota Twins Player Prop Facts

  • James Outman has hit a home run in three of his last four appearances in day games against AL teams that held a winning record.
  • Trevor Larnach has recorded at least one hit in each of the Twins’ last six day games against AL opponents that held a winning record.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their win over the Twins from Friday’s opener to sit at 55-54 on the year. After this series, the Guardians will take to the road for a series against the New York Mets.

Guardians Win Three In A Row

Steven Kwan has 115 hits as part of a .286 batting average and 9 home runs, 20 doubles and 38 RBIs. Kyle Manzardo has 71 hits with 13 doubles, 2 triples, 18 home runs and 47 RBIs as well this year. Gabriel Arias has 19 doubles but also 94 strikeouts and Manzardo has 86 strikeouts so far this season. Arias has also added 7 home runs and 34 RBIs and Jose Ramirez has chipped in 21 home runs and 56 RBIs with 31 stolen bases as well. Carlos Santana has also added 81 hits with 11 home runs and 46 RBIs as well this season.

Why the Cleveland Guardians will win

  • The Guardians have won each of their last nine day games against the Twins following a win.
  • The Twins have lost eight of their last nine road games after going to extra innings.
  • The Guardians have covered the run line in each of their last nine day games against the Twins following a win.
  • The Twins have failed to cover the run line in each of their last seven day games against AL Central opponents.

Cleveland Guardians Player Prop Facts

  • Carlos Santana has hit a home run in two of the Guardians’ last three games against the Twins.
  • Will Brennan has recorded at least one hit in each of his last nine appearances against the Twins.

Total Runs Facts

  • Each of the last four games between the Twins and Guardians at Progressive Field have gone UNDER the total runs line.
  • Six of the Twins’ last seven road games against AL Central opponents have gone UNDER the total runs line.

Minnesota Twins vs. Cleveland Guardians Prediction

I’m leaning towards the Guardians here. It would be nice to know who the Twins are starting here, but with how many players Minnesota shipped out at the trade deadline, it’s kind of understandable that they’re even still trying to figure out who is still there. The bottom line is the Twins showed their hand with their trade deadline and how it was handled, and this is a team that’s playing for the future. This is the time of year when the Guardians normally turn it on and after finding a way to win on Friday, I think they rally behind Bibee for a win here as well. Give me the Guardians at home in this one.

Chris Ruffolo's Pick: Cleveland Guardians TBA

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