Minnesota Twins vs Chicago White Sox Prediction 5/26/2026 Today’s MLB Picks

The Minnesota Twins and the Chicago White Sox meet Tuesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Joe Ryan here and Ryan is 3-3 with a 3.02 ERA and 61 strikeouts this season. In his last five starts against the White Sox, Ryan is 3-0 with a 3.26 ERA and 35 strikeouts. Sean Burke will start here for Chicago is 2-3 with a 4.08 ERA and 46 strikeouts this season. This will be Burke’s second career start against the Twins.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to bounce back from their 3-1 loss at the hands of the White Sox to fall to 26-28 this season. After this series, the Twins will head on the road for a series against the Pittsburgh Pirates.

Twins Have Four-Game Win Streak Snapped

Byron Buxton has 50 hits with 10 doubles, a triple, 16 home runs and 26 RBIs while Josh Bell’s added 42 hits with 8 doubles, 5 home runs and 30 RBIs. Luke Keaschall has 42 hits with 8 doubles, a homer and 18 RBIs and Matt Wallner has 20 hits with 3 doubles, 4 home runs and 10 RBIs. Brooks Lee has 6 home runs with 27 RBIs and Victor Caratini has 17 RBIs while Ryan Jeffers has 36 hits with 6 doubles, a triple, 7 home runs and 26 RBIs this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to add on to their win over the Twins from Monday to improve to 27-26 this season. After this series, the White Sox will take on the Detroit Tigers in a series at home.

White Sox Snap Two-Game Slide

Munetaka Murakami has 44 hits with 18 home runs and 37 RBIs while Miguel Vargas has 44 hits with 8 doubles, a triple, 12 home runs and 31 RBIs and Colson Montgomery has 41 hits with 8 doubles, 13 home runs and 32 RBIs. Luisangel Acuna has 16 hits and Tristan Peters has 32 hits with 6 doubles so far this season. Chase Meidroth also has 50 hits with 9 doubles, 4 home runs and 13 RBIs this year.

Minnesota Twins @ the Chicago White Sox Betting Trends: May 26, 2026

• Probable Starting Pitcher: Sean Burke      Record this season: 2-3      ERA: 4.08
• Home Record: 0-2
• Last 5 against Twins: 0-1

Why the Chicago White Sox will win

• The White Sox have won each of their last six games as underdogs against the Twins.
• The Twins have lost nine of their last 10 games as favorites against AL Central opponents.
• The White Sox have covered the run line in each of their last 15 home games against American League opponents following a home win.
• The Twins have failed to cover the run line in nine of their last 10 games as favorites against AL Central opponents.
• The Twins have lost the first inning in three of their last four games as road favorites against American League opponents.
• The White Sox have led after 5 innings in each of their last six home games against AL Central opponents that held a losing record.
• The Twins have trailed after 3 innings in each of their last nine games as road favorites against American League opponents.

• Probable Starting Pitcher: Joe Ryan      Record this season: 3-3      ERA: 3.02
• Road Record: 1-1
• Last 5 against White Sox: 3-0

Why the Minnesota Twins will win

• The Twins have won five of their last six road games.
• The White Sox have lost five of their last six home games against the Twins following a win.
• The Twins have covered the run line in each of their last five games following a loss.
• The White Sox have trailed after 5 innings in four of their last five games as underdogs.

Total Runs Facts

• Each of the White Sox’s last six games as home underdogs have gone OVER the total runs line.
• Seven of the Twins’ last eight games as road favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the White Sox’s last 10 home games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last four games.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in two of the White Sox’s last three games as home underdogs.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last 12 games as home underdogs.
• Munetaka Murakami ranks 2nd in the league in Home Runs (18) this season.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit at least one home run in each of his last three appearances at Rate Field against opponents that held a winning record.
• Joe Ryan has recorded a win in three of his last four appearances against the White Sox.
• Joe Ryan has recorded seven or more strikeouts in four of his last five appearances against the White Sox.
• Byron Buxton has recorded at least one hit in each of his last seven road appearances.
• Byron Buxton ranks T4th in the league in Home Runs (16) this season.

Matchup/League Facts

• The White Sox rank 30th in the league for doubles this season (63).
• The White Sox rank T2nd in the league for home runs this season (72).
• The Twins rank T25th in the league for strikeouts this season (414).
• The Twins rank T6th in the league for home runs allowed this season (48).

Minnesota Twins vs. Chicago White Sox Prediction

I’m on the White Sox here. I just think that the White Sox lineup is one that’s going to provide a lot of value in spots and while Joe Ryan’s been really solid and has really good numbers in his career against the White Sox, I still don’t trust this Twins bullpen and I think that Chicago picks up another W in this one. Give me the White Sox.

Chris Ruffolo's Pick: Chicago White Sox +105