Milwaukee Brewers vs Pittsburgh Pirates Prediction 5/22/25 MLB Picks

The Milwaukee Brewers and the Pittsburgh Pirates meet Thursday in MLB action from PNC Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Milwaukee Brewers vs. Pittsburgh Pirates prediction.

Starting Pitching Matchup

The Milwaukee Brewers did not have a starting pitcher announced at the time that this article was posted. The Pittsburgh Pirates will send out Mike Burrows here for his major league debut.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to bounce back from an 8-4 loss at the hands of the Baltimore Orioles on Wednesday to fall to 24-26 on the year. After this series, the Brewers will head home for an interleague series against the Boston Red Sox.

Brewers Have Three-Game Win Streak Snapped

Brice Turang has 51 hits with 4 home runs, 20 RBIs, and 13 stolen bases, while Jackson Chourio has 51 hits with a team-high 14 doubles, 7 home runs, and 26 RBIs, and Sal Frelick has 44 hits as well as 3 triples and 9 stolen bases so far this season. Christian Yelich also has 8 stolen bases with 7 homers and 26 RBIs while also adding 4 doubles. Yelich also has a team-high 56 strikeouts up to this point in the year. William Contreras has 4 homers and 23 RBIs as well this season. Rhys Hoskins has added 45 hits with 7 home runs, 27 RBIs, and 9 doubles.

Why the Milwaukee Brewers will win

• The Pirates have lost each of their last six night games against National League opponents following a win.
• The Brewers have won 10 of their last 12 night games against the Pirates following a home loss.
• The Pirates have failed to cover the run line each of their last six games against NL Central opponents that held a losing record.
• The Brewers have covered the run line in eight of their last nine road games against National League opponents following a loss.

Milwaukee Brewers Player Prop Facts

• William Contreras has recorded at least one hit in each of his last 12 road appearances against NL opponents.
• Jackson Chourio has scored at least one run in seven of the Brewers’ last eight games against NL opponents that held a losing record.
• Christian Yelich has recorded at least one RBI in each of the Brewers’ last four night games against NL teams that held a losing record.
• William Contreras has recorded a Single in each of his last nine road appearances against NL opponents.
• Jackson Chourio has recorded a Double in five of the Brewers’ last six games against NL opponents that held a losing record.
• Rhys Hoskins has hit a home run in each of the Brewers’ last two games against opponents that held a losing record.

Pittsburgh Pirates Recap

The Pittsburgh Pirates come into this game looking to build on their 3-1 win over the Cincinnati Reds from Wednesday’s series finale to fall to 17-33 on the year. After this series, the Pirates will head on the road for a series against the Arizona Diamondbacks.

Pirates Looking To Carry Over Positive Vibes

Bryan Reynolds has 39 hits with 5 doubles, 6 home runs, and 24 RBIs while also leading the Pirates with 59 strikeouts so far this season. Oneil Cruz has posted a team-high 8 home runs and 18 RBIs with 18 stolen bases, while Isiah Kiner-Falefa has 36 hits with 7 stolen bases. Emmanuel Valdez also has a pair of triples this season. Tommy Pham has 4 doubles and Andrew McCutchen has 34 hits with 7 doubles, and KeBryan Hayes has 43 hits with 15 RBIs and 5 stolen bases.

Why the Pittsburgh Pirates will win

• The Brewers have lost each of their last six night games following a loss.
• The home team has won five of the Pirates’ last six games.
• The Brewers have failed to cover the run line in each of their last five night games following a loss.
• The Pirates have covered the run line in five of their last six games at PNC Park.

Pittsburgh Pirates Player Prop Facts

• Oneil Cruz has scored a run in four of his last five appearances against NL Central opponents.
• Joey Bart has recorded at least one RBI in each of his last four home appearances against NL Central opponents that held a losing record.
• Tommy Pham has recorded at least one Single in each of his last nine Thursday appearances against NL Central teams that held a losing record.
• Bryan Reynolds has hit a home run in two of his last three home appearances against NL Central opponents that held a losing record.
• Tommy Pham has recorded at least one hit in each of his last nine Thursday appearances against NL Central teams that held a losing record.

Total Runs Facts

• Each of the Pirates’ last eight home games have gone UNDER the total runs line.
• Seven of the Brewers’ last eight night games after playing the previous day have gone UNDER the total runs line.

Milwaukee Brewers vs. Pittsburgh Pirates Prediction

I’m on the Brewers here. It would be nice to know who the Brewers are sending out for this start, but the thing is that I’m not sure it matters with how inconsistent the Pirates continue to be at the plate. The Brewers didn’t have the greatest finish to their series against the slumping Orioles, but they’re still the better team in this matchup and, in my eyes, probably a better team than their record to this point in the year. I’ll roll with the Brewers to draw first blood on the road in this one.