Los Angeles Angels vs Seattle Mariners Prediction 9/25/2026 Today’s MLB Picks

The Los Angeles Angels and Seattle Mariners meet Friday in MLB action at T-Mobile Park. Here’s a Los Angeles Angels vs. Seattle Mariners Prediction. This article will include a Los Angeles Angels vs. Seattle Mariners Pick.

Los Angeles Angels Betting Preview

The Los Angeles Angels are 61-98 on the year. The Los Angeles Angels are batting .234 on the season, have a .310 OBP, and have a .369 slugging percentage. The Los Angeles Angels’ pitching staff has a 4.26 ERA and a 1.35 WHIP. Zach Neto leads the Los Angeles Angels with 145 hits and 75 RBI, while Mike Trout and Nolan Schanuel have combined for 232 hits and 103 RBI.

Reid Detmers gets the ball for the Los Angeles Angels, and he is 6-8 with a 3.47 ERA and 204 strikeouts this season. Detmers is 3-2 with a 5.15 ERA and 53 strikeouts in his career against the Seattle Mariners.

Seattle Mariners Betting Preview

The Seattle Mariners are 74-85 on the year. The Seattle Mariners are batting .231 on the season, have a .312 OBP, and have a .378 slugging percentage. The Seattle Mariners’ pitching staff has a 4.21 ERA and a 1.27 WHIP. Randy Arozarena leads the Seattle Mariners with 156 hits and 76 RBI, while Julio Rodriguez and Josh Naylor have combined for 302 hits and 125 RBI.

Bryce Miller gets the ball for the Seattle Mariners, and he is 4-9 with a 3.99 ERA and 112 strikeouts this season. Miller is 3-2 with a 2.58 ERA and 55 strikeouts in his career against the Los Angeles Angels.

Why the Seattle Mariners will win

• The Angels have lost each of their last six night games against AL West opponents following a road win.
• The home team has won 12 of the last 15 games between the Angels and Mariners.
• The Angels have failed to cover the run line in seven of their last eight games against teams that held a losing record.

Why the Los Angeles Angels will win

• The Mariners have lost each of their last seven Friday night games as favorites against AL opponents.
• The Angels have won each of their last three games as road underdogs against AL opponents.
• The Mariners have failed to cover the run line in each of their last 12 Friday night games.
• The underdogs have covered the run line in each of the Mariners’ last six games.

Total Runs Facts

• Each of the Angels’ last five road games after playing the previous day have gone OVER the total runs line.
• Eleven of the Mariners’ last 13 night games after playing the previous day have gone OVER the total runs line.
• There has been no run scored during the first inning in 13 of the Angels’ last 15 games as road underdogs against AL opponents.
• There has been no run scored during the first inning in each of Bryce Miller’s last four appearances as a starter against the Angels.

Seattle Mariners Player Prop Facts

• Bryce Miller has recorded five or more strikeouts in each of his 11 previous appearances at T-Mobile Park against AL West opponents that held a losing record.
• Josh Naylor has hit a home run in four of his last 12 home appearances against the Angels.
• Julio Rodriguez has recorded at least one hit in each of the Mariners’ last 10 games as favorites against AL opponents.

Los Angeles Angels Player Prop Facts

• Reid Detmers has recorded eight or more strikeouts in six of his last eight appearances against AL West opponents that held a losing record.
• Mike Trout has hit at least one home run in eight of his last 14 appearances at T-Mobile Park against AL West opponents that held a losing record.
• Zach Neto has recorded at least one hit in each of the Angels’ last nine games as road underdogs against AL West opponents.

Matchup/League Facts

• The Mariners rank 29th in the league for batting average this season (.231).
• The Mariners rank 2nd in the league for walks allowed this season (429).
• The Angels rank 29th in the league for runs scored this season (641).
• The Angels rank 29th in the league for home runs this season (151).

Los Angeles Angels vs Seattle Mariners Prediction

Two teams that have nothing to play for, and I’ve made a living fading the Angels over the years. However, the Mariners shouldn’t be laying juice at this point in the season, and Miller has been hit or miss through 112.2 innings. You can argue this is Detmers best season with a 3.47 ERA and 1.05 WHIP through 179 innings. Detmers has allowed 43 hits and 13 runs in his last 54 innings. He’s been dealing. Detmers doesn’t get run support from a trash Angels team, but he’s pitching well. Give me the plus money.

Randy Chambers's Pick: Los Angeles Angels