Jun 12, 2025; Kansas City, Missouri, USA; Kansas City Royals starting pitcher Seth Lugo (67) delivers a pitch against the New York Yankees in the first inning at Kauffman Stadium. Mandatory Credit: Denny Medley-Imagn Images

Kansas City Royals vs San Diego Padres Prediction 06/22/2025 Picks

Pick details

Kansas City (38-39) vs San Diego (41-35)

June 22, 2025 at 04:10 PM EDT

The Line: Betting Odds: San Diego +1.5 — Over/Under: +8.5

(Get latest betting odds)

In this article, we will formulate a Royals vs Padres prediction for this MLB game on Sunday, June 22, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

Kansas City Royals Betting Preview

The Kansas City Royals (38-39, 19-20 Away) were on a four-game winning run but couldn’t make it five in a row after losing to San Diego last night. Following a series sweep of the Texas Rangers on the road, the Royals opened the current series against the Padres with a 6-5 win on Friday, but suffered a 5-1 defeat in Game 2. John Rave drove in the lone run for the Royals, while Noah Cameron took the loss after allowing two runs on five hits with two strikeouts and three walks in 5.1 innings.

This year, the Royals average 3.38 runs per game (29th in the MLB) on a .247/.301/.371 triple-slash. When it comes to pitching, the Royals’ staff has a 3.41 ERA (4th) and 1.21 WHIP (7th). Vinnie Pasquantino leads the Royals with a .267 batting average, 11 home runs, and 41 RBI this season.

The projected starting pitcher for the Royals is Seth Lugo, who is 4-5 in 13 starts this season, with a 3.05 ERA and 1.11 WHIP in 76.2 innings.

San Diego Padres Betting Preview

The San Diego Padres (41-35, 21-13 Home) lost three consecutive series to the Dodgers, Diamondbacks, and Dodgers again, and are hoping to avoid the fourth loss in a row here in a rubber match against the Royals. In last night’s 5-1 victory over the Royals, Fernando Tatis Jr. hit a three-run homer to lead his offense, while Dylan Cease got the win after allowing one run on three hits with four strikeouts and three walks across 6.2 innings of work.

This season, the Padres average 4.24 runs per game (15th in the MLB) on a .250/.317/.381 triple-slash. When it comes to pitching, the Padres’ staff has a 3.60 ERA (9th) and 1.22 WHIP (10th). Manny Machado leads the Padres with a .309 batting average, 12 home runs, and 46 RBI this season.

Randy Vasquez will take the mound for the Padres on Sunday. The 26-year-old right-hander has a 3-4 record in 15 starts this year with a 3.70 ERA and 1.36 WHIP in 73.0 innings.

Total Runs Facts

Seven of the Padres’ last eight day games against AL Central opponents have gone UNDER the total runs line.
Each of the Royals’ last four day games after playing the previous day have gone UNDER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Padres’ last eight day games.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Royals’ last seven Sunday day games against NL West opponents.

Matchup/League Facts

The Padres rank T26th in the league for home runs this season (65).
The Padres rank 5th in the league for hits allowed this season (568).
The Royals rank 29th in the league for home runs this season (55).
The Royals rank 2nd in the league for strikeouts against this season (524).

Royals vs Padres Prediction

The teams have traded victories in the past couple of years, each recording five in the previous ten H2H encounters. It’s a trick one to bet on out of all the games on Sunday, but I am going with Under here. Seth Lugo didn’t have the best of months in May, but he is pitching much better in June, allowing three runs in three starts. Randy Vasquez, on the other hand, has been in a hot and cold form lately, but I am backing him to be hot against one of the worst offensive teams. Go with Under.

Oliver Zivic's Pick: Under 8.5

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