Houston Astros vs Tampa Bay Rays Prediction 5/21/25 MLB Picks

The Houston Astros and Tampa Bay Rays meet Wednesday in MLB action at George M. Steinbrenner Field. Here’s a Houston Astros vs Tampa Bay Rays Prediction. This article will include a Houston Astros vs Tampa Bay Rays Pick.

Houston Astros Betting Preview

The Houston Astros are 25-23 on the year and play the Mariners, Athletics, and Rays next. The Houston Astros are batting .247 on the season, have a .318 OBP, and a .375 slugging percentage. The Houston Astros’ pitching staff has a 3.38 ERA and a 1.12 WHIP. Jeremy Pena leads the Houston Astros with 55 hits and 23 RBI, while Isaac Paredes and Jose Altuve have combined for 90 hits and 39 RBI. 

Hunter Brown gets the ball for the Houston Astros, and he is 6-2 with a 1.43 ERA and 67 strikeouts this season. Brown is 2-0 with a 1.06 ERA and 17 strikeouts in his career against the Tampa Bay Rays.

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 22-26 on the year and play the Blue Jays, Twins, and Astros next. The Tampa Bay Rays are batting .240 on the season, have a .304 OBP, and a .360 slugging percentage. The Tampa Bay Rays pitching staff has a 3.88 ERA and a 1.22 WHIP. Yandy Diaz leads the Tampa Bay Rays with 45 hits and 24 RBI, while Jonathan Aranda and Junior Caminero have combined for 84 hits and 43 RBI.

Taj Bradley gets the ball for the Tampa Bay Rays, and he is 3-3 with a 4.80 ERA and 41 strikeouts this season. Bradley is 1-2 with a 9.95 ERA and 16 strikeouts in his career against the Houston Astros.

Why the Tampa Bay Rays will win

• The Rays have won nine of their last 10 Wednesday day games as home underdogs against American League opponents.
• The Astros have lost each of their last five day games against AL East opponents following a loss.
• The Rays have covered the run line in nine of their last 10 games as home underdogs against American League opponents.
• The Astros have failed to cover the run line in each of their last five games as favorites against American League opponents.
• The Rays have led after 5 innings in four of their last five games as underdogs.

Why the Houston Astros will win

• The Astros have won each of their last six day games against American League opponents following a loss.
• The Rays have lost seven of their last eight day games following a home win.
• The Rays have failed to cover the run line in each of their last six home games against American League opponents.
• The Astros have covered the run line in nine of their last 10 day games against American League opponents following a road loss.
• The Astros have led after 3 innings in each of their last four games against AL East opponents.
• The Astros have led after 5 innings in nine of their last 10 road games against AL East opponents.

Tampa Bay Rays Player Prop Facts

• Josh Lowe has hit a home run in two of his last three appearances with the Rays as underdogs against AL West opponents.
• Brandon Lowe has recorded two or more RBIs in three of the Rays’ last four games as underdogs against AL opponents.
• Brandon Lowe has recorded at least one hit in each of his last eight appearances against AL West opponents.
• Ha-Seong Kim has recorded at least one Single in each of his last five appearances against AL opponents that held a winning record.
• Ha-Seong Kim has scored a run in each of his last three appearances against opponents that held a winning record.
• Jonathan Aranda ranks 10th amongst qualified players for On Base Percentage (.396) this season.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in each of the Astros’ last three games as favorites.
• Jake Meyers has recorded an RBI in five of the Astros’ last six road games against AL East opponents.
• Jeremy Pena has recorded at least one Single in 11 of the Astros’ last 12 games as favorites against AL opponents.
• Isaac Paredes has recorded at least one hit in each of his last 10 appearances against opponents that held a losing record.
• Yordan Alvarez has scored at least one run in each of the Astros’ last four day games against AL East opponents that held a losing record.
• Hunter Brown ranks 2nd amongst qualified players for Earned Run Average (1.43) this season.

Houston Astros vs Tampa Bay Rays Prediction

The Astros have done a good job of rebounding from losses over the last week or so, and Brown is on the mound here. With a 1.43 ERA, 0.83 WHIP, and 67 strikeouts, Brown looks like a CY Young contender. Brown has allowed seven earned runs in his last 50.2 innings. In 56.2 innings, Brown is allowing a .170 batting average, and it drops to a .143 allowed batting average in 91 at-bats against left-handed hitters. It’s filthy, folks. It doesn’t matter what you think of Bradley or the Rays as a team. I’m not stepping in front of the Astros with Brown on the mound. The price is reasonable. Give me the Astros.