Houston Astros vs Seattle Mariners Prediction 4/10/2026 Today’s MLB Picks

The Houston Astros and the Seattle Mariners meet Friday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Seattle Mariners prediction.

Starting Pitching Matchup

The Houston Astros will send out Tatsuya Imai for the start here and Imai is 1-0 with a 4.32 ERA and 13 strikeouts this season. This will be Imai’s first career start against the Mariners. Seattle will trot out Emerson Hancock for the start here and Hancock is 1-1 with a 0.71 ERA and 14 strikeouts this season. In his career, Hancock is 1-0 with a 3.38 ERA and 5 strikeouts against Seattle.

Houston Astros Recap

The Houston Astros come into this game looking to bounce back from their 9-1 loss at the hands of Colorado last time out to sit at 6-7 this season. After this series, the Astros will head home for a rematch series with the Colorado Rockies.

Astros Drop 4th In A Row

Yordan Alvarez has 13 hits with 3 doubles, 4 home runs and 10 RBIs while Christian Walker has 17 hits with 6 doubles, 3 home runs and 13 RBIs on the year. Jose Altuve’s chipped in 15 hits with 4 doubles, 2 home runs and 6 RBIs and Carlos Correa has 11 hits with 2 doubles, a home run and 9 RBIs. Cam Smith also has 12 hits with 2 doubles, 3 home runs and 6 RBIs.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from a 3-0 loss at the hands of the Texas Rangers last time out to sit at 4-9 this season. After this series, the Mariners will head on the road for a set against the San Diego Padres.

Mariners Lose 5th In A Row and 7th Of Last 8

Brendan Donovan has 12 hits with 2 doubles, 3 home runs and 5 RBIs while Luke Raley has 3 home runs and 6 RBIs this season. Cole Young’s added 12 hits with 2 doubles, a triple, 2 home runs and 8 RBIs and Cal Raleigh has 7 hits with 2 doubles, a home run and 6 RBIs as well this season. Randy Arozarena has 11 hits with 3 doubles and 3 RBIs as well on the year.

Houston Astros @ Seattle Mariners Betting Trends: April 10, 2026

• Probable Starting Pitcher: Emerson Hancock      Record this season: 1-1      ERA: 0.71
• Home Record: 1-0
• Last 5 against Astros: 1-0

Why the Seattle Mariners will win

• The Mariners have won each of their last 10 home games against teams that held a losing record.
• The Astros have lost each of their last four games.
• The Astros have failed to cover the run line in 13 of their last 15 night games against AL West opponents that held a losing record.
• The home team has covered the run line in each of the Astros’ last four games.
• The Mariners have led after 3 innings in each of their last five games against the Astros.
• The Mariners have led after 5 innings in each of their last five night games against the Astros.

• Probable Starting Pitcher: Tatsuya Imai      Record this season: 1-0      ERA: 4.32
• Road Record: 1-0
• Last 5 against Mariners: –

Why the Houston Astros will win

• The underdogs have won each of the Astros’ last seven games.
• The Mariners have lost each of their last four games as favorites.
• The Astros have covered the run line in each of their last 10 games as underdogs following a road loss.
• The Mariners have failed to cover the run line in each of their last four games as favorites.
• The Astros have won the first inning in each of their last three games as underdogs.
• The Astros have led after 3 innings in three of their last four night games against American League opponents that held a losing record.
• The Mariners have trailed after 5 innings in each of their last four games as favorites.

Total Runs Facts

• Each of the Astros’ last eight games against American League opponents have gone OVER the total runs line.
• Each of the Mariners’ last six night games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last 11 games at T-Mobile Park.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last seven night games between the Astros and Mariners at T-Mobile Park.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit a home run in each of the Mariners’ last two games against the Astros.
• Randy Arozarena has recorded at least one hit in each of the Mariners’ last six games against opponents that held a losing record.

Houston Astros Player Prop Facts

• Christian Walker has hit at least one home run in five of his last six road appearances against AL West opponents.
• Christian Walker has recorded at least one hit in 26 of his last 27 road appearances against opponents that held a losing record.
• Yordan Alvarez ranks 1st amongst qualified players for On Base Percentage (.500) this season.

Matchup/League Facts

• The Mariners rank 30th in the league for batting average this season (.184).
• The Mariners rank 30th in the league for slugging percentage this season (.301).
• The Astros rank 1st in the league for runs scored this season (79).
• The Astros rank 1st in the league for hits this season (122).

Houston Astros vs. Seattle Mariners Prediction

I’m on the under in this one. Both of these teams are struggling offensviely right now and neither one is one that I really feel like backing if we’re being 100% honest. The under just seems like the play because of inefficient offense and I think this could easily be a first to 3 wins type of game. Give me the under.

Chris Ruffolo's Pick: Under 7.5