Houston Astros vs Oakland Athletics Prediction 4/4/2026 Today’s MLB Picks

In this article, we will formulate an Astros vs Athletics Prediction for this MLB matchup on Saturday, April 4th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Athletics Preview

The Athletics have a 2-5 record this season and are sitting in the last place of the AL West. They have a 1-0 home record and are coming off an 11-4 home win over the Astros. Their previous three games were a 1-5 road loss, a 5-2 road win and a 0-4 road loss to the Braves.

The Athletics have a .206 batting average this season, .266 OBP and .348 Slugging percentage. Oakland’s pitching staff has a 4.28 ERA and 1.48 WHIP. Shea Langeliers is the team’s best hitter with a .333 batting average, also leading the team in RBI with 8 and adding a team-high 5 home runs.

Luis Morales (R) is the projected starting pitcher for the Athletics, and he has a 0-1 record, 10.38 ERA and 1.62 WHIP.

Houston Astros Preview

The Houston Astros have a 5-3 record this season and are sitting in the first place of the AL West. They have a 0-1 road record and are coming off a 4-11 road loss to the Athletics. Their previous three games were a 6-4, a 9-2 and an 8-1 home win over the Red Sox.

The Astros have a .259 batting average this season, .357 OBP and .440 Slugging percentage. Houston’s pitching staff has a 5.45 ERA and 1.46 WHIP. Yordan Alvarez is the team’s best hitter with a .400 batting average, also adding a team-high three home runs. Carlos Correa leads the team in RBI with 7.

Tatsuya Imai (R) is the projected starting pitcher for the Astros, and he has a 0-0 record, 13.50 ERA and 2.63 WHIP.

Houston Astros @ Athletics Betting Trends: April 4, 2026

• Probable Starting Pitcher: Luis Morales      Record this season: 0-1      ERA: 10.38
• Home Record: 0-0
• Last 5 against Astros: –

Why the Athletics will win

• The Athletics have won seven of their last eight games as underdogs against the Astros.
• The Astros have lost four of their last five games as favorites against the Athletics following a loss.
• The home team has covered the run line in each of the Astros’ last six games.
• The Astros have failed to cover the run line in four of their last five games at Sutter Health Park.
• The Athletics have led after 3 innings in four of their last five games as underdogs against AL West opponents.
• The Athletics have led after 5 innings in eight of their last nine games against the Astros.

• Probable Starting Pitcher: Tatsuya Imai      Record this season: 0-0      ERA: 13.50
• Road Record: 0-0
• Last 5 against Athletics: –

Why the Houston Astros will win

• The Astros have won each of their last 10 day games against AL West opponents following a road loss.
• The Athletics have lost each of their last six day games after playing the previous day.
• The Astros have covered the run line in seven of their last eight games after playing the previous day.
• The Athletics have failed to cover the run line in each of their last five day games against AL West opponents.
• The Athletics have trailed after 3 innings in each of their last six day games.
• The Athletics have trailed after 5 innings in each of their last six day games.
• The Athletics have lost the first inning in each of their last five day games against AL West opponents.

Total Runs Facts

• Each of the Astros’ last six games have gone OVER the total runs line.
• Seven of the Athletics’ last eight games as underdogs against AL West opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Athletics’ last seven day games against AL West opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the Astros’ last 15 road games against AL West opponents.

Athletics Player Prop Facts

• Shea Langeliers has hit a home run in four of the Athletics’ last six games as underdogs against the Astros.
• Brent Rooker has recorded at least one hit in each of the Athletics’ last 12 Saturday day games against opponents that held a winning record.
• Shea Langeliers ranks T1st in the league in Home Runs (5) this season.

Houston Astros Player Prop Facts

• Christian Walker has hit at least one home run in each of his last three road appearances after playing the previous day.
• Christian Walker has recorded at least one hit in 21 of his last 22 road appearances against opponents that held a losing record.
• Yordan Alvarez ranks T3rd in the league in Home Runs (3) this season.

Matchup/League Facts

• The Athletics rank 29th in the league for on-base percentage this season (.266).
• The Athletics rank 29th in the league for strikeouts this season (47).
• The Astros rank 1st in the league for runs scored this season (49).
• The Astros rank 1st in the league for doubles this season (21).

Astros vs Athletics Prediction

The Athletics are 8-1 in their last 9 meetings against the Astros and are 4-1 in their last 5 meetings at home.

In this Astros vs Athletics Prediction, the Astros are coming as -115 road favorites. The Astros saw their five-game winning streak getting snapped yesterday and today they are going with Tatsuya Imai on the mound who got lit up in just 2.2 innings pitched in his first start. Morales is also coming of a terrible first start to the season where he gave up 5 runs in 4.1 innings pitched and both teams are a perfect 7-0 to the over in their last 7 games combined, as they average 10.5 runs per game combined. This is going to be a slugfest so take the over 10 runs.

Nikos Lagouretos's Pick: Over 10