Houston Astros vs Los Angeles Angels Prediction 9/26/2025 Today’s MLB Picks

In this article, we will formulate an Astros vs Angels Prediction for this MLB game on Friday, September 26th at the Angel Stadium in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Preview

The Los Angeles Angels have a 71-88 record this season and are sitting on the 4th place of the AL West. The Angels have a 38-40 home record and 87-69 in over/under They are coming off a 4-9 home defeat by the Royals, and are 1-3 in their last 4 games.

The Angels have a .226 batting average this season, .298 OBP and .398 Slugging percentage. LA’s pitching staff has a 4.89 ERA and 1.44 WHIP. Taylor Ward leads the Angels with 131 hits, while Nolan Schanuel is the team’s best hitter with a .267 batting average. Taylor Ward leads the team with 103 RBI, while Jo Adell adds a team-high 37 home runs.

Kyle Hendricks (R) is the projected starting pitcher for the Angels, and he has an 8-10 record, 4.79 ERA and 1.28 WHIP.

Houston Astros Preview

The Houston Astros have an 85-74 record this season and are sitting on the second place of the AL West. The Astros have a 39-39 road record and 73-80 in over/under. They are coming off a 11-5 road win over the A’s, which ended their five-game losing streak. 

The Astros have a .250 batting average this season, .316 OBP and .396 slugging percentage. Houston’s pitching staff has a 3.89 ERA and 1.23 WHIP. Jose Altuve leads the Astros with 155 hits, adding a team-high 26 home runs. Jeremy Pena is the team’s best hitter with a .304 batting average, while Christian Walker leads the team in RBI with 85. 

Jason Alexander (R) is the projected starting pitcher for the Astros, and he has a 4-2 record, 4.83 ERA and 1.39 WHIP.

Houston Astros @ Los Angeles Angels Betting Trends: September 26, 2025

• Probable Starting Pitcher: Kyle Hendricks      Record this season: 8-10      ERA: 4.79
• Home Record: 5-5
• Last 5 against Astros: 1-1

Why the Los Angeles Angels will win

• The Angels have won seven of their last eight games as home underdogs against American League opponents following a home loss.
• The Astros have lost 10 of their last 12 games as favorites against American League opponents following a win.
• The Angels have covered the run line in each of their last 13 games as underdogs against American League opponents following a home loss.
• The Astros have failed to cover the run line in 11 of their last 12 night games against AL West opponents that held a losing record.
• The Astros have trailed after 3 innings in four of their last five night games.
• The Astros have trailed after 5 innings in each of their last five night games.

• Probable Starting Pitcher: Jason Alexander      Record this season: 4-2      ERA: 4.83
• Road Record: 4-0
• Last 5 against Angels: –

Why the Houston Astros will win

• The Astros have won each of their last 16 Friday games against the Angels.
• The Angels have lost each of their last eight Friday games.
• The Angels have failed to cover the run line in eight of their last nine games as underdogs.
• The Astros have covered the run line in seven of their last eight night games following a road win.
• The Angels have lost the first inning in four of their last five games against American League opponents.
• The Angels have trailed after 3 innings in three of their last four games against American League opponents.
• The Angels have trailed after 5 innings in five of their last six games against American League opponents.

Total Runs Facts

• Six of the Astros’ last seven road games against American League opponents have gone UNDER the total runs line.
• Five of the Angels’ last six home games against AL West opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last six games between the Astros and Angels.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Astros’ last 11 road games against AL West opponents.

Los Angeles Angels Player Prop Facts

• Taylor Ward has hit a home run in each of his last three appearances in night games.
• Kyle Hendricks has recorded a win in three of his last four home appearances against AL opponents that held a winning record.
• Kyle Hendricks has recorded five or more strikeouts in each of his last three appearances.
• Luis Rengifo has recorded at least one hit in each of his last 10 appearances against the Astros after playing the previous day.
• Jo Adell ranks T8th in the league in Home Runs (37) this season.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in four of his last five appearances with the Astros as favorites against the Angels.
• Christian Walker has recorded a Double in three of the Astros’ last four games as road favorites against AL West opponents.
• Christian Walker has recorded at least one hit in each of the Astros’ last 19 road games against opponents that held a losing record.

Matchup/League Facts

• The Angels rank 30th in the league for doubles this season (209).
• The Angels rank 30th in the league for batting average this season (.226).
• The Astros rank 1st in the league for strikeouts this season (1480).
• The Astros rank T26th in the league for triples this season (12).

Astros vs Angels Prediction

Both teams are tied 3-3 wins in their last 6 meetings, and the Astros are 2-1 in their last 3 meetings in LA. Under is 3-1 in their last 4 meetings.  

In this Astros vs Angels Prediction, the Astros are coming as -150 road favorites. The Astros have fallen off the Wild Card spots with their recent struggles, and are now putting Jason Alexander on the mound, whom I don’t trust, especially on the road. He is coming off a terrible start, having given up 7 runs in just 1.1 innings pitched against the Mariners, but he has been far better on the road, with a 3.19 ERA. The Astros also have a superior bullpen and a better offense to back him up, and they are in desperate need of every win they can get. Take the Houston Astros on the moneyline on the road.