Jun 20, 2025; Anaheim, California, USA; Houston Astros shortstop Jeremy Pena (3) celebrates with designated hitter Jose Altuve (27) after hitting a home run in the first inning against the Los Angeles Angels at Angel Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Houston Astros vs Los Angeles Angels Prediction 06/22/2025 Picks

Pick details

Houston (44-33) vs Los Angeles (37-39)

June 22, 2025 at 04:07 PM EDT

The Line: Betting Odds: Los Angeles +1.5 — Over/Under: +9

(Get latest betting odds)

In this article, we will formulate an Astros vs Angels prediction for this MLB game on Sunday, June 22, at Angel Stadium in Anaheim, California. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Betting Preview

The Houston Astros (44-33, 17-20 Away) are unbeaten in the last eight series and will try to extend that run to nine in a rubber match against the Angels here. Recently, the Astros have swept the Minnesota Twins and split with the Athletics. They beat the Angels in Game 1, but were well beaten in Game 2, losing 9-1. Christian Walker drove in the lone run for Houston, while Brandon Walter took the loss after allowing seven runs on nine hits with six strikeouts and one walk in 6.0 innings.

This season, the Astros average 4.22 runs per game (17th in the MLB) on a .256/.322/.399 triple-slash. When it comes to pitching, the Astros’ staff has a 3.48 ERA (5th) and 1.15 WHIP (2nd). Isaac Paredes leads the Astros with a .254 batting average, 16 home runs, and 45 RBI this season.

Ryan Gusto will take the mound for the Astros on Sunday. The 26-year-old right-hander has a 4-3 record in ten starts this year with a 4.31 ERA and 1.53 WHIP in 54.1 innings.

Los Angeles Angels Betting Preview

The Los Angeles Angels (37-39, 16-17 Home) bounced back from a series loss against the Baltimore Orioles, who swept them in three games, with a series win over the Yankees on the road. The Angels responded to a Game 1 defeat to the Astros in the current series with a comfortable 9-1 victory on Saturday. Logan O’Hoppe led the offense with a couple of homers and four RBI, while Jose Soriano got the win after allowing one run on three hits with ten strikeouts and three walks across 6.2 innings of work.

This year, the Angels average 4.13 runs per game (22nd in the MLB) on a .225/.288/.401 triple-slash. When it comes to pitching, the Angels’ staff has a 4.58 ERA (24th) and 1.45 WHIP (28th). Taylor Ward leads the Angels with a .210 batting average, 19 home runs, and 52 RBI this season.

The projected starting pitcher for the Angels is Kyle Hendricks, who is 5-6 in 14 starts this season, with a 4.79 ERA and 1.29 WHIP in 77.0 innings.

Total Runs Facts

Each of the Angels’ last five games as underdogs against American League opponents have gone UNDER the total runs line.
Four of the Astros’ last five day games after playing the previous day have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Angels’ last six day games against American League opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last four day games against American League opponents.

Matchup/League Facts

The Angels rank 29th in the league for steals this season (35).
The Angels rank 29th in the league for strikeouts against this season (740).
The Astros rank 2nd in the league for hits allowed this season (551).
The Astros rank T3rd in the league for runs allowed this season (280).

Astros vs Angels Prediction

The Astros won seven of the previous ten H2H encounters, including three out of five this season. Seven of the last ten H2Hs went Over, and I am backing another high-scoring affair in this one. Ryan Gusto allowed multiple runs in four of his last five starts and surrendered three runs in 4.0 innings in his previous start against the Angels. Kyle Hendricks, on the other hand, allowed multiple runs in seven of his last eight starts and surrendered five runs in 4.0 innings the last time he faced the Astros. Go with Over.

Oliver Zivic's Pick: Over 9.5

Need More? Get Premium Picks

Hot Cappers this week

Latest Picks & Game Previews

  • Carlos Alcaraz vs Taylor Fritz Prediction 07/11/2025 Wimbledon Picks

    July 11, 2025

  • Jannik Sinner vs Novak Djokovic Prediction 07/11/2025 Wimbledon Picks

    July 11, 2025

  • MLB Player Prop Picks 07/11/2025 Picks (American League Pitchers)

    July 11, 2025

  • MLB Player Prop Picks 07/11/2025 Picks (National League Pitchers)

    July 11, 2025

  • Iga Swiatek vs Amanda Anisimova Prediction 07/12/2025 Wimbledon Picks

    July 12, 2025