Jul 9, 2025; Houston, Texas, USA; Cleveland Guardians third baseman Jose Ramirez (11) celebrates with  right fielder Jhonkensy Noel (43) after defeating the Houston Astros  at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images

Guardians vs White Sox Prediction 07/11/2025 Picks

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Cleveland (43-48) vs Chicago (31-62)

July 11, 2025 at 08:10 PM EDT

The Line: Betting Odds: Chicago +1.5 — Over/Under: +8

(Get latest betting odds)

In this article we will formulate a Guardians vs White Sox prediction for this MLB game on Friday, July 11th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB doubleheader.

Cleveland Guardians Betting Preview
The Cleveland Guardians are 43-48 this year after they won all three games against Houston by scores of 7-5, 10-6, and 4-2. In their game three win, Cleveland scored the first four runs in the game and they were able to hang on in the later innings for the victory. The Guardians recorded six hits in the game and they were led by Rodriguez, who went 1-4 with two RBIs in the win. Cleveland started Cecconi, who allowed five hits and two earned runs over 7.0 innings for the win, while Sewald picked up the save. 

Prior to that series, the Guardians lost all three against the Tigers and all three against the Cubs. Cleveland has lost 10 of their last 13 games and they are currently fourth in the AL Central standings. The Cleveland pitching staff has a 3.97 ERA with a 1.36 WHIP and a .248 opponent batting average, while the offense has scored 333 runs with a .224 batting average and a .295 on base percentage this season. Jose Ramirez has led Cleveland with 17 home runs and 45 RBIs, while Kyle Manzardo has added 13 home runs and 33 RBIs this year. The projected starting pitcher for Cleveland in game one is Logan Allen, who is 5-7 with a 4.07 ERA and a 1.43 WHIP over 84.0 innings pitched this year. The projected starting pitcher for game two is Gavin Williams, who is 5-4 with a 3.61 ERA and a 1.41 WHIP over 92.1 innings pitched. 

Chicago White Sox Betting Preview
The Chicago White Sox are 31-62 this season after they lost two out of three against Toronto by scores of 4-8, 1-6, and 2-1. In their game three win, Chicago fell behind 1-0 in the second inning, but they scored the last two runs in the game for the victory. The White Sox recorded six hits and they committed one error in the game, while they were led by Quero and Sosa, who both had one RBI in the win. Chicago started Houser, who allowed seven hits and one earned run over 7.0 innings for the win, while Leasure picked up the save.

Prior to that series, the White Sox won two out of three against the Rockies, but did lose all three games against the Dodgers before that. Chicago has lost six of their last nine games and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.14 ERA with a 1.40 WHIP and a .254 opponent batting average, while the offense has scored 318 runs with a .222 batting average and a .296 on base percentage this season. Miguel Vargas has led Chicago with 10 home runs and 34 RBIs, while Andrew Benintendi has also added 10 home runs and 34 RBIs this year. The projected starting pitcher for Chicago in game one is Shane Smith, who is 3-7 with a 4.20 ERA and a 1.33 WHIP over 83.2 innings pitched this season. The projected starting pitcher for game two is Jonathan Cannon, who is 3-7 with a 4.50 ERA and a 1.46 WHIP over 72.0 innings pitched.

Why the White Sox will beat the Guardians
The White Sox have won three of their last four games as underdogs against AL Central opponents.
The Guardians have lost each of their last four games against AL Central opponents.
The White Sox have covered the run line each of their last four home games against teams that held a losing record.
The Guardians have failed to cover the run line in 16 of their last 20 night games against AL Central opponents that held a losing record.
The White Sox have led after 5 innings in three of their last four home games against AL Central opponents that held a losing record.

Why the Guardians will beat the White Sox
The Guardians have won each of their last seven night games against AL Central opponents following a win.
The White Sox have lost each of their last seven games against American League opponents that held a losing record.
The Guardians have covered the run line each of their last six road games against AL Central opponents that held a losing record.
The White Sox have failed to cover the run line in eight of their last nine games at Rate Field against AL Central opponents that held a losing record.
The White Sox have trailed after 5 innings in four of their last five games against American League opponents that held a losing record.
The White Sox have trailed after 3 innings in four of their last five games against American League opponents that held a losing record.

Total Runs Facts
Six of the Guardians’ last seven night games against AL Central opponents have gone UNDER the total runs line.
Six of the White Sox’s last seven games as underdogs against American League opponents have gone UNDER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last four games as underdogs against American League opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Guardians’ last 11 games as favorites against American League opponents.

Chicago White Sox Player Prop Facts
Michael A. Taylor has recorded a Double in three of his last four appearances after playing the previous day.
Mike Tauchman has recorded at least one hit in each of the White Sox’s last nine games against opponents that held a losing record.
Andrew Benintendi has hit a home run in three of his last eight appearances at Rate Field.

Cleveland Guardians Player Prop Facts
Brayan Rocchio has recorded a Double in three of the Guardians’ last four night games.
Jose Ramirez has hit a home run in each of the Guardians’ last three games against AL opponents.
Carlos Santana has recorded at least one hit in each of his last six road appearances against AL Central opponents.
Jose Ramirez ranks T4th in the league in Steals (25) this season.

Matchup/League Facts
The White Sox rank 30th in the league for batting average this season (.222).
The White Sox rank 29th in the league for hits this season (672).
The Guardians rank 29th in the league for on-base percentage this season (.295).
The Guardians rank 28th in the league for slugging percentage this season (.366).

Guardians vs White Sox Prediction 
Cleveland finally picked up some momentum with a series sweep over Houston earlier this week and they need to keep that going in this series to get back in the AL Central race. The Guardians are 23-25 on the road this year, while the White Sox are 20-26 at home. In game one, we have seen Smith really struggle for Chicago in recent starts, so give me the Guardians to win. In game two, we have seen each pitcher be very inconsistent, so I think we can go over this low total. 

David Racey's Pick: Game 1: Guardians ML Game 2: Over 7.5

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