Detroit Tigers vs Boston Red Sox Prediction 9/27/2025 Today’s MLB Picks

In this article, we will formulate a Tigers vs Red Sox Prediction for this MLB game on Saturday, September 27th at the Fenway Park in the second game of this series, with the Red Sox having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Boston Red Sox Preview

The Boston Red Sox have an 88-72 record this season and are sitting on the third place of the AL East. The Red Sox have a 47-32 home record and are 76-80 in over/under. They are coming off a 4-3 home victory over the Tigers, and are 3-1 in their last 4 games.

The Red Sox have a .255 batting average this season, .324 OBP and .422 slugging percentage. Boston’s pitching staff has a 3.72 ERA and 1.29 WHIP. Trevor Story leads the Red Sox with 161 hits, while is the team’s best hitter, with a .265 batting average. He also leads the team in RBI, with 96, adding a team-high 25 home runs.

Connelly Early (L) is the projected starting pitcher for the Red Sox, and he has a 1-1 record, 1.88 ERA and 1.12 WHIP.

Detroit Tigers Preview

The Detroit Tigers have an 86-74 record this season and are sitting on the first place of the AL Central. The Tigers have a 40-39 road record and are 83-69 in over/under. They are coming off a 3-4 road defeat by the Red Sox, and are 1-9 in their last 10 games. Under is 4-1 in their last 5 games.

The Tigers have a .247 batting average this season, .316 OBP and .415 slugging percentage. Detroit’s pitching staff has a 3.96 ERA and 1.25 WHIP. Riley Greene leads the Tigers with 155 hits, adding team-highs both in RBI, with 111, and in home runs, with 36. Zach McKinstry is the team’s best hitter with a .261 batting average.

Tarik Skubal (R) is the projected starter for the Tigers, and he has a 13-6 record, 2.21 ERA and 0.89 WHIP.

Detroit Tigers @ Boston Red Sox Betting Trends: September 27, 2025

• Probable Starting Pitcher: Connelly Early      Record this season: 1-1      ERA: 1.88
• Home Record: 0-0
• Last 5 against Tigers: –

Why the Boston Red Sox will win

• The home team has won each of the last six games between the Tigers and Red Sox.
• The Tigers have lost nine of their last 10 games.
• The Tigers have failed to cover the run line in seven of their last eight games following a loss.
• The Red Sox have covered the run line in five of their last six day games against American League opponents that held a winning record.
• The Red Sox have led after 5 innings in 11 of their last 12 day games at Fenway Park against AL Central opponents.
• The Red Sox have led after 3 innings in five of their last six day games against the Tigers at Fenway Park.

• Probable Starting Pitcher: TBD

Why the Detroit Tigers will win

• The Tigers have won 15 of their last 16 day games against American League opponents following a road loss.
• The Red Sox have lost five of their last six day games against the Tigers at Fenway Park following a win.
• The Tigers have covered the run line in 11 of their last 12 day games against AL East opponents that held a winning record.
• The Red Sox have failed to cover the run line in seven of their last eight home games.
• The Red Sox have lost the first inning in each of their last three day games.
• The Tigers have led after 3 innings in six of their last seven day games against AL East opponents.
• The Red Sox have trailed after 5 innings in each of their last four day games.

Total Runs Facts

• Eight of the Red Sox’s last nine games against AL Central opponents have gone OVER the total runs line.
• Each of the Tigers’ last four road games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 14 of the Tigers’ last 16 day games against AL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last five day games against American League opponents.

Boston Red Sox Player Prop Facts

• Alex Bregman has recorded at least one hit in 15 of his last 16 appearances in day games against AL Central teams that held a winning record.
• Wilyer Abreu has hit a home run in each of his last two appearances in day games against AL Central teams that held a winning record.
• Trevor Story has recorded a Double in three of the Red Sox’s last four day games.

Detroit Tigers Player Prop Facts

• Kerry Carpenter has hit a home run in three of his last four Saturday day appearances.
• Parker Meadows has recorded at least one hit in each of his last 12 appearances against AL East opponents.

Matchup/League Facts

• The Red Sox rank 1st in the league for doubles this season (320).
• The Red Sox rank 4th in the league for hits this season (1400).
• The Tigers rank 30th in the league for steals this season (60).
• The Tigers rank T2nd in the league for triples this season (36).

Tigers vs Red Sox Prediction

The Tigers are 5-1 in their last 6 meetings against the Red Sox, but the Red Sox are 3-2 in their last 5 meetings in Boston. Over is 7-3 in their last 10 meetings.  

The Tigers currently hold the third Wild Card spot of the AL, and need every win they can get in order to keep it secure. The Red Sox officially clinched their playoff spot with yesterday’s win and are putting a rookie on the mound today. On the flip side, the Tigers are putting Skubal on the mound for this crucial game, who has been in excellent form lately, having one earned run in each of his last two starts, and one earned run or less in six of his last seven starts. Take the Detroit Tigers to get the job done on the road in this one.