Colorado Rockies vs San Francisco Giants Prediction 9/26/2025 Today’s MLB Picks

The Colorado Rockies and San Francisco Giants meet Friday in MLB action at Oracle Park. Here’s a Colorado Rockies vs San Francisco Giants Prediction. This article will include a Colorado Rockies vs San Francisco Giants Pick.

Colorado Rockies Betting Preview

The Colorado Rockies are 43-116 on the year after playing the Mariners. The Colorado Rockies are batting .238 on the season, have a .294 OBP, and a .387 slugging percentage. The Colorado Rockies pitching staff has a 5.99 ERA and a 1.59 WHIP. Hunter Goodman leads the Colorado Rockies with 147 hits and 90 RBI while Jordan Beck and Mickey Moniak have combined for 255 hits and 120 RBI.

German Marquez gets the ball for the Colorado Rockies, and he is 3-15 with a 6.49 ERA and 82 strikeouts this season. Marquez is 5-11 with a 6.82 ERA and 93 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 78-81 on the year after playing the Cardinals. The San Francisco Giants are batting .235 on the season, have a .311 OBP, and a .385 slugging percentage. The San Francisco Giants pitching staff has a 3.88 ERA and a 1.31 WHIP. Heliot Ramos leads the San Francisco Giants with 157 hits and 66 RBI while Jung Hoo Lee and WIlly Adames have combined for 274 hits and 137 RBI.

Trevor McDonald gets the ball for the San Francisco Giants, and he is 0-0 with a 3.38 ERA and 4 strikeouts this season. This will be McDonald’s first career game against the Colorado Rockies.

Colorado Rockies @ San Francisco Giants Betting Trends: September 26, 2025

• Probable Starting Pitcher: Trevor McDonald      Record this season: 0-0      ERA: 3.38
• Home Record: 0-0
• Last 5 against Rockies: –

Why the San Francisco Giants will win

• The Rockies have lost each of their last 13 games at Oracle Park against NL West opponents that held a losing record.
• The Giants have won each of their last 11 games against the Rockies at Oracle Park following a win.
• The Giants have covered the run line each of their last nine Friday night games against National League opponents that held a losing record.
• The Rockies have failed to cover the run line in 11 of their last 12 games at Oracle Park against teams that held a losing record.
• The Giants have led after 5 innings in 13 of their last 15 home games against NL West opponents that held a losing record.
• The Rockies have lost the first inning in six of their last seven road games against NL West opponents that held a losing record.
• The Giants have led after 3 innings in each of their last eight Friday night games.

• Probable Starting Pitcher: German Marquez      Record this season: 3-15      ERA: 6.49
• Road Record: 2-6
• Last 5 against Giants: 1-3

Why the Colorado Rockies will win

• The Giants have lost each of their last four games as home favorites.
• The underdogs have won six of the Giants’ last seven games at Oracle Park.
• The Giants have failed to cover the run line in 23 of their last 26 games as home favorites against National League opponents.
• The underdogs have covered the run line in six of the Giants’ last seven games at Oracle Park.

Total Runs Facts

• Each of the Rockies’ last five games as underdogs against National League opponents have gone OVER the total runs line.
• Five of the Giants’ last six games as favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Giants’ last eight games as home favorites against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Rockies’ last five night games at Oracle Park.

San Francisco Giants Player Prop Facts

• Matt Chapman has recorded a Double in three of his last four appearances in night games against NL teams that held a losing record.
• Rafael Devers has hit a home run in three of the Giants’ last four night games.
• Matt Chapman has recorded at least one hit in each of his last 10 appearances in night games against teams that held a losing record.

Colorado Rockies Player Prop Facts

• Brenton Doyle has hit a home run in three of his last four road appearances against NL opponents that held a losing record.
• German Marquez has recorded four or more strikeouts in 10 of his last 12 road appearances against NL West opponents that held a losing record.
• Ezequiel Tovar has recorded at least one hit in each of his last nine appearances with the Rockies as underdogs against the Giants.

Matchup/League Facts

• The Giants rank 28th in the league for doubles this season (236).
• The Giants rank 26th in the league for hits this season (1243).
• The Rockies rank 30th in the league for ERA this season (5.99).
• The Rockies rank 30th in the league for strikeouts this season (1076).

Colorado Rockies vs San Francisco Giants Prediction

The Giants have nothing to play for now that they’ve been eliminated, and they haven’t won two straight games since September 9. McDonald also has just 11 MLB innings under his belt, so he’s not somebody I’m running to bet, given the small sample size. However, the Rockies are one of the worst teams in baseball history and are a club we’ve been fading all year. That doesn’t stop now. Marquez has been terrible this season, and that includes allowing 28 hits and 18 runs in his last 19.1 innings. No, thanks. Keep fading the Rockies until the season ends.