Colorado Rockies vs Houston Astros Prediction 4/16/2026 Today’s MLB Picks

The Colorado Rockies and the Houston Astros meet Thursday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Rockies vs. Houston Astros prediction.

Starting Pitching Matchup

The Colorado Rockies will send out Juan Mejia for the start here and Mejia is 0-2 with a 5.40 ERA and 5 strikeouts this season. This will be Mejia’s first career start against the Astros. Ryan Weiss will start this one for the Astros and is 0-2 with a 7.36 ERA and 15 strikeouts this season. This will be Weiss’ first career start against the Rockies.

Colorado Rockies Recap

The Colorado Rockies come into this game looking to bounce back from a 3-1 loss at the hands of Houston last time out to sit at 6-12 this season. After this series, the Rockies will head home for a series against the Los Angeles Dodgers.

Rockies Drop 6th Straight

Entering Wednesday, TJ Rumfield has 17 hits with a double, a triple, 2 home runs and 8 RBIs while Ezequiel Tovar has 17 hits with 7 doubles, a home run and 6 RBIs. Hunter Goodman’s added 15 hits with a double, 4 home runs and 7 RBIs and Jordan Beck has 6 RBIs as well on the year. Troy Johnston has 14 hits with 3 doubles, 2 home runs and 7 RBIs. Willi Castro also has 11 hits with 3 doubles, a home run and 7 RBIs.

Houston Astros Recap

The Houston Astros come into this game fresh off of their win over the Rockies ton Wednesday improve to 8-11 on the year. After this series, the Astros will take on the St. Louis Cardinals at home.

Astros Win Back-To-Back Games

Going into Wednesday’s matchup, Yordan Alvarez has 19 hits with 5 doubles, 6 home runs and 16 RBIs while Christian Walker has 20 hits with 6 doubles, 4 home runs and 15 RBIs on the year. Jose Altuve’s chipped in 19 hits with 5 doubles, 2 home runs and 6 RBIs and Carlos Correa has 17 hits with 3 doubles, a home run and 9 RBIs. Cam Smith also has 18 hits with 4 doubles, 3 home runs and 9 RBIs. Yainer Diaz also has 11 hits with a double, a home run and 9 RBIs.

Colorado Rockies @ Houston Astros Betting Trends: April 16, 2026

• Probable Starting Pitcher: Ryan Weiss      Record this season: 0-2      ERA: 7.36
• Home Record: 0-0
• Last 5 against Rockies: 0-1

Why the Houston Astros will win

• The home team has won each of the Astros’ last 10 games.
• The Rockies have lost each of their last 13 road games against teams that held a losing record.
• The Astros have covered the run line in each of their last six night games against National League opponents following a win.
• The Rockies have failed to cover the run line in each of their last five games after playing the previous day.
• The Astros have won the first inning in four of their last five home games.
• The Rockies have trailed after 5 innings in each of their last 13 road games against opponents that held a losing record.
• The Rockies have trailed after 3 innings in eight of their last nine road games against opponents that held a losing record.

• Probable Starting Pitcher: Juan Mejia      Record this season: 0-2      ERA: 5.40
• Road Record: 0-2
• Last 5 against Astros: 1-0

Why the Colorado Rockies will win

• The Astros have lost five of their last seven games as favorites.
• The Rockies have won four of their last six games as underdogs against American League opponents.
• The Astros have failed to cover the run line in each of their last seven Thursday home games.
• The Rockies have covered the run line in five of their last six games against the Astros.
• The Rockies have led after 3 innings in each of their last five Thursday games against AL West opponents that held a losing record.
• The Astros have lost the first inning in six of their last seven games.

Total Runs Facts

• Six of the Astros’ last seven home games have gone OVER the total runs line.
• Eighteen of the Rockies’ last 23 games as underdogs against the Astros have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last seven games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Rockies’ last four games.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit a home run in three of the Astros’ last four night games.
• Christian Walker has recorded at least one hit in 25 of his last 26 appearances against the Rockies after playing the previous day.

Colorado Rockies Player Prop Facts

• Willi Castro has recorded at least one hit in each of his last 10 appearances against the Astros after playing the previous day.
• Kris Bryant has hit a home run in four of his last six appearances against the Astros.

Matchup/League Facts

• The Astros rank 1st in the league for doubles this season (48).
• The Astros rank 30th in the league for ERA this season (6.17).
• The Rockies rank 30th in the league for strikeouts against this season (189).
• The Rockies rank 29th in the league for strikeouts this season (127).

Colorado Rockies vs. Houston Astros Prediction

I’m on the Astros here. I get the case to be made for either side in this game, but the thing is that until the Rockies show that they can win a game on the road, it’s fade them in that spot at all costs. The Astros have used this series to get some confidence, just like the Mariners did against them the series prior and I think Houston completes the sweep here. Give me Houston.

Chris Ruffolo's Pick: Houston -185