May 21, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks right fielder Corbin Carroll (7) is doused with gum by Arizona Diamondbacks left fielder Lourdes Gurriel Jr. (12) after hitting a walk off single against the Colorado Rockies during the ninth inning at Chase Field. Mandatory Credit: Joe Camporeale-Imagn Images
Joe Camporeale-Imagn Images

Colorado Rockies vs Arizona Diamondbacks Prediction 5/22/2026 Today’s MLB Picks

Pick details

MATCHUP Colorado Rockies Arizona Diamondbacks
Team Records 19-32 26-23
Spread +1.5 -117 -1.5 -103
Moneyline +178 -218
Total Over 9 (-101) Under 9 (-120)
Where Chase Field, Phoenix, Arizona
When Friday, May 22, 2026
Time 09:40 PM EDT
TV MLB.TV

The Colorado Rockies and Arizona Diamondbacks meet Friday in MLB action at Chase Field. Here’s a Colorado Rockies vs Arizona Diamondbacks Prediction. This article will include a Colorado Rockies vs Arizona Diamondbacks Pick.

Colorado Rockies Betting Preview

The Colorado Rockies are 19-32 on the year and play the Giants and Dodgers next. The Colorado Rockies are batting .243 on the season and have a .311 OBP, and a .383 slugging percentage. The Colorado Rockies pitching staff has a 4.94 ERA and a 1.47 WHIP. TJ Rumfield leads the Colorado Rockies with 50 hits and 25 RBI while Troy Johnston and Mickey Moniak have combined for 90 hits and 50 RBI.

Tomoyuki Sugano gets the ball for the Colorado Rockies, and he is 4-3 with a 4.02 ERA and 25 strikeouts this season. This will be Sugano’s second career game against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 26-23 on the year and play the Mariners and Giants next. The Arizona Diamondbacks are batting. 244 on the season, have a .311 OBP, and have a .399 slugging percentage. The Arizona Diamondbacks’ pitching staff has a 4.17 ERA and a 1.26 WHIP. Ildemaro Vargas leads the Arizona Diamondbacks with 55 hits and 32 RBI while Ketel Marte and Corbin Carroll have combined for 90 hits and 48 RBI.

Michael Soroka gets the ball for the Arizona Diamondbacks, and he is 6-2 with a 3.49 ERA and 55 strikeouts this season. Soroka is 1-2 with a 2.87 ERA and 23 strikeouts in his career against the Colorado Rockies.

Why the Arizona Diamondbacks will win

  • The Rockies have lost 18 of their last 19 road games against NL West opponents.
  • The Diamondbacks have won each of their last six games at Chase Field.
  • The Rockies have failed to cover the run line in seven of their last eight games as underdogs against NL West opponents following a road loss.
  • The Diamondbacks have covered the run line in five of their last six games at Chase Field.
  • The Diamondbacks have led after 5 innings in four of their last five night games against the Rockies at Chase Field.
  • The Diamondbacks have led after 3 innings in six of their last eight games against the Rockies at Chase Field.

Why the Colorado Rockies will win

  • The Diamondbacks have failed to cover the run line in each of their last six night games against the Rockies at Chase Field following a home win.
  • The Rockies have covered the run line in each of their last four games following a loss.

Total Runs Facts

  • Six of the Rockies’ last seven night games against NL West opponents have gone UNDER the total runs line.
  • Four of the last five games between the Rockies and Diamondbacks have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the last six games between the Rockies and Diamondbacks at Chase Field.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in five of Tomoyuki Sugano’s last six appearances as a starter.

Arizona Diamondbacks Player Prop Facts

  • Nolan Arenado has hit a home run in three of his last seven appearances in night games against NL teams that held a losing record.
  • Michael Soroka has recorded a win in four of his last five appearances in night games.
  • Michael Soroka has recorded six or more strikeouts in four of his last five appearances with his team as a home favorite against NL West opponents.
  • Gabriel Moreno has recorded at least one hit in each of his last eight appearances with the Diamondbacks as favorites against the Rockies.
  • Ildemaro Vargas ranks 3rd amongst qualified players for Batting Average (.325) this season.

Colorado Rockies Player Prop Facts

  • TJ Rumfield has recorded at least one hit in each of his last eight road appearances after playing the previous day.
  • Brenton Doyle has hit a home run in each of his last two appearances at Chase Field.
  • Troy Johnston ranks 5th amongst qualified players for Batting Average (.324) this season.

Matchup/League Facts

  • The Diamondbacks rank T2nd in the league for doubles this season (91).
  • The Diamondbacks rank 4th in the league for strikeouts against this season (375).
  • The Rockies rank T2nd in the league for doubles this season (91).
  • The Rockies rank 29th in the league for strikeouts against this season (472).

Colorado Rockies vs Arizona Diamondbacks Prediction

The Rockies are looking more and more like the Rockies we expected to see out of the gate, and I’m going to continue fading them. The Diamondbacks have played their best ball over the last week and Soroka has been strong with a 3.49 ERA and 1.33 WHIP through 49 innings. Sugano has allowed 17 hits and 11 runs in his last 15.1 innings. Give me the Diamondbacks for another victory.

Randy Chambers's Pick: Arizona Diamondbacks

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